iPTMnet Report for Q16890 (TPD52L1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16890 / TPD53_HUMAN
Protein Name Tumor protein D53
Gene Name Name: TPD52L1
Organism Homo sapiens (Human)

PRO ID PR:Q16890
DAG View
PRO Name tumor protein D53 (human)
Definition A tumor protein D53 that is encoded in the genome of human.
Short Label hTPD52L1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16890 (TPD52L1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus   UniProt 24275569
K60 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y96 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus   UniProt 23186163
K123 Methylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus   UniProt 23186163
R133 Methylation PhosphoSitePlus   UniProt 24129315
S135 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
T146 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S149 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T157 Phosphorylation phospho.ELM 18669648
T159 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus   UniProt 23186163
S186 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S86 Phosphorylation HPRD 19651622
T102 Phosphorylation HPRD 18212344
S137 Phosphorylation HPRD 20166139
S144 Phosphorylation HPRD 20068231
T146 Phosphorylation HPRD 18669648
S149 Phosphorylation HPRD 19651622, 20166139, 18669648, ...20068231
T157 Phosphorylation HPRD 18669648
S174 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
S86 Phosphorylation HPRD 19651622
T102 Phosphorylation HPRD 18212344
S137 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
S86 Phosphorylation HPRD 19651622
T102 Phosphorylation HPRD 18212344
Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation HPRD 19651622
T73 Phosphorylation HPRD 18212344
S108 Phosphorylation HPRD 20166139
S115 Phosphorylation HPRD 20068231
T117 Phosphorylation HPRD 18669648
S120 Phosphorylation HPRD 19651622, 20166139, 18669648, ...20068231
T128 Phosphorylation HPRD 18669648
S145 Phosphorylation HPRD 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S57 R57 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S86 R86 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y96 S96 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K98 I98 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc, cosmic, icgc ]
S115 Y115 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K123 R123 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S131 F131 Biomuta DOID:1319 / brain cancer [ cosmic ]
R133 C133 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R133 H133 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S144 Y144 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S160 T160 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K162 N162 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T163 M163 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S186 G186 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S189 N189 Biomuta DOID:4159 / skin cancer [ cosmic ]