iPTMnet Report Q16877 PFKFB4

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q16877 / F264_HUMAN
Protein Name	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
Gene Name	Name: PFKFB4
Organism	Homo sapiens (Human)

PRO ID	PR:Q16877 DAG View
PRO Name	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (human)
Definition	A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 that is encoded in the genome of human.
Short Label	hPFKFB4
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q16877 (PFKFB4) as Substrate

Q16877

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S3	Phosphorylation		score1	PhosphoSitePlus
	K13	Ubiquitination		score1	PhosphoSitePlus
	K87	Ubiquitination		score1	PhosphoSitePlus
	K101	Ubiquitination		score1	PhosphoSitePlus
	K104	Ubiquitination		score1	PhosphoSitePlus
	S119	Phosphorylation		score1	PhosphoSitePlus
	T131	Phosphorylation		score1	PhosphoSitePlus
	T140	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	36109523
	S176	Phosphorylation		score1	PhosphoSitePlus
	S204	Phosphorylation		score1	IEDB	35494241
	S214	Phosphorylation		score1	PhosphoSitePlus
	K265	Ubiquitination		score1	PhosphoSitePlus
	S275	Phosphorylation		score1	PhosphoSitePlus
	K283	Ubiquitination		score1	PhosphoSitePlus
	K295	Ubiquitination		score1	PhosphoSitePlus
	K305	Ubiquitination		score1	PhosphoSitePlus
	K362	Ubiquitination		score1	PhosphoSitePlus
	C415	Methylation		score1	IEDB	31844290

Q16877 (PFKFB4) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	Q9Y6Q9 (NCOA3)	S857	score1	Signor	29615789

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S176	R176	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]
K362	E362	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
K362	N362	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]
C415	Y415	Biomuta		[ cosmic ]