iPTMnet Report for Q16875 (PFKFB3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16875 / F263_HUMAN
Protein Name 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Gene Name Name: PFKFB3
Organism Homo sapiens (Human)

PRO ID PR:Q16875
DAG View
PRO Name 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (human)
Definition A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 that is encoded in the genome of human.
Short Label hPFKFB3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16875 (PFKFB3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K12 Ubiquitination PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
S171 O-Glycosylation GlyGen 32060258, 30100348, 32830957
S172 O-Glycosylation GlyGen 32060258, 30100348, 32830957
S172 Phosphorylation PhosphoSitePlus   RLIMS-P 32060258
K176 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus   RLIMS-P+ 27585591
S269 Phosphorylation O14920 (IKBKB) RLIMS-P+ 27585591
S273 Phosphorylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
Y363 Phosphorylation PhosphoSitePlus
C394 Methylation IEDB 31844290
K411 Ubiquitination PhosphoSitePlus
S461 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 23186163, 16115917, 12065600, ...29620138, 29410405, 9836440, 28235572, 18669648, 32198345, 23548149, 30226266, 22115192, 15896703, 29113354, 19690332, 20068231, 33580152
S461 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 15896703, 9836440
S461 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 15896703, 9836440
S461 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 15896703
S461 Phosphorylation P49137 (MAPKAPK2) PhosphoSitePlus 23548149
S461 Phosphorylation Q13131 (PRKAA1) neXtProt   PhosphoSitePlus   Signor 12065600
S461 Phosphorylation Q15418 (RPS6KA1) RLIMS-P+ 22115192
T463 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S467 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
T471 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus   RLIMS-P 33931981
Site PTM Type PTM Enzyme Score Source PMID
S273 Phosphorylation HPRD 18452278
S461 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20166139, 20068231
T463 Phosphorylation HPRD 18767875, 18669648
S467 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K189 N189 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S273 N273 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K411 E411 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S461 C461 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S467 N467 Biomuta DOID:9256 / colorectal cancer [ cosmic ]