Protein Information

Cytoscape View

UniProt AC / UniProt ID Q16836 / HCDH_HUMAN
Protein Name Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor
Gene Name Name: HADH
Organism Homo sapiens (Human)

PRO ID PR:Q16836
DAG View
PRO Name hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (human)
Definition A hydroxyacyl-coenzyme A dehydrogenase, mitochondrial that is encoded in the genome of human.
Short Label hHADH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q16836 (HADH) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
R75 Methylation PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K81 Acetylation PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K132 Acetylation PhosphoSitePlus
K136 Acetylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
K185 Acetylation PhosphoSitePlus   UniProt 19608861
K185 Ubiquitination PhosphoSitePlus
K192 Acetylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
K202 Acetylation PhosphoSitePlus   UniProt 19608861
K202 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
Y226 Phosphorylation PhosphoSitePlus
Y234 Phosphorylation PhosphoSitePlus
K241 Acetylation PhosphoSitePlus   UniProt 19608861
K241 Ubiquitination PhosphoSitePlus
K249 Acetylation PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K304 Acetylation PhosphoSitePlus
K312 Acetylation PhosphoSitePlus   UniProt 19608861
K312 Methylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K136 N136 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K202 E202 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
K212 N212 Biomuta DOID:3571 / liver cancer [ icgc ]
Y226 H226 Biomuta DOID:1909 / melanoma [ tcga ]
K301 R301 Biomuta DOID:2531 / hematologic cancer [ icgc ]