iPTMnet Report for Q16828 (DUSP6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16828 / DUS6_HUMAN
Protein Name Dual specificity protein phosphatase 6
Gene Name Name: DUSP6
Synonyms:MKP3,PYST1;
Organism Homo sapiens (Human)

PRO ID PR:Q16828
DAG View
PRO Name dual specificity protein phosphatase 6 (human)
Definition A dual specificity protein phosphatase 6 that is encoded in the genome of human.
Short Label hDUSP6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16828 (DUSP6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C39 Methylation IEDB 31844290
K68 Ubiquitination PhosphoSitePlus
C127 Methylation IEDB 31844290
S159 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15632084
S174 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   RLIMS-P 19106095
S178 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S197 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 15632084, 29375309
K254 Ubiquitination PhosphoSitePlus
Y255 Phosphorylation PhosphoSitePlus
S300 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   RLIMS-P 19106095
K324 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
S328 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S331 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S351 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S159 Phosphorylation P28482 (MAPK1) HPRD 15632084
S197 Phosphorylation P28482 (MAPK1) HPRD 15632084
S328 Phosphorylation HPRD 20230923
S331 Phosphorylation HPRD 19413330, 18669648, 18452278, ...20230923
S351 Phosphorylation HPRD 19664994
Site PTM Type PTM Enzyme Score Source PMID
S182 Phosphorylation HPRD 20230923
S185 Phosphorylation HPRD 19413330, 18669648, 18452278, ...20230923
S205 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C127 Y127 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S159 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S178 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S182 F182 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S300 L300 Biomuta DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K327 T327 Biomuta DOID:9256 / colorectal cancer [ cosmic ]