iPTMnet Report for Q16825 (PTPN21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16825 / PTN21_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 21
Gene Name Name: PTPN21
Synonyms:PTPD1;
Organism Homo sapiens (Human)

PRO ID PR:Q16825
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 21 (human)
Definition A tyrosine-protein phosphatase non-receptor type 21 that is encoded in the genome of human.
Short Label hPTPN21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16825 (PTPN21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T284 Phosphorylation PhosphoSitePlus
S492 Phosphorylation HPRD   PhosphoSitePlus 18077418
S504 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
T578 Phosphorylation PhosphoSitePlus
Y586 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus   UniProt 21406692
S658 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
S797 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
T915 Phosphorylation PhosphoSitePlus
Y1157 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S504 P504 Biomuta DOID:363 / uterine cancer [ icgc ]
T578 M578 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y586 H586 Biomuta DOID:4159 / skin cancer [ cosmic ]
S670 L670 Biomuta DOID:4159 / skin cancer [ cosmic ]
S820 L820 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T915 S915 Biomuta DOID:4159 / skin cancer [ icgc ]
T915 I915 Biomuta DOID:4159 / skin cancer [ icgc ]