Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16822 / PCKGM_HUMAN
Protein Name Phosphoenolpyruvate carboxykinase [GTP], mitochondrial precursor
Gene Name Name: PCK2
Synonyms:PEPCK2;
Organism Homo sapiens (Human)

PRO ID PR:Q16822
DAG View
PRO Name phosphoenolpyruvate carboxykinase [GTP], mitochondrial (human)
Definition A phosphoenolpyruvate carboxykinase [GTP], mitochondrial that is encoded in the genome of human.
Short Label hPCK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16822 (PCK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S34 Phosphorylation PhosphoSitePlus
T42 Phosphorylation PhosphoSitePlus   UniProt 24275569
R45 Methylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus   UniProt 24275569
T196 Phosphorylation PhosphoSitePlus   UniProt 24275569
K234 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus   UniProt 24275569
S422 Phosphorylation PhosphoSitePlus
R479 Methylation PhosphoSitePlus
K491 Acetylation PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K624 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T42 I42 Biomuta DOID:363 / uterine cancer [ tcga ]
R45 * Biomuta DOID:1793 / pancreatic cancer [ tcga ]
R45 L45 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R479 H479 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R479 C479 Biomuta DOID:11934 / head and neck cancer [ tcga ]