Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16777 / H2A2C_HUMAN
Protein Name Histone H2A type 2-C
Gene Name Name: H2AC20
Synonyms:H2AFQ,HIST2H2AC;
Organism Homo sapiens (Human)

PRO ID PR:Q16777
DAG View
PRO Name histone H2A type 2-C (human)
Definition A histone H2A type 2-C that is encoded in the genome of human.
Short Label hH2AC20
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16777 (H2AC20) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
S2 Acetylation UniProt 15823041, 16457589
S2 Phosphorylation PRO   PhosphoSitePlus 15010469
K6 Acetylation PRO   PhosphoSitePlus   UniProt 17709392, 16457589
K6 Methylation PhosphoSitePlus
K10 Acetylation PRO   PhosphoSitePlus 18552846, 12937907
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination UniProt 22713238, 22980979
K16 Ubiquitination UniProt 22713238, 22980979
S20 Phosphorylation PhosphoSitePlus
R21 Methylation PhosphoSitePlus
R30 Methylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
Y51 Phosphorylation PhosphoSitePlus
R72 Methylation PhosphoSitePlus
R82 Methylation PhosphoSitePlus
R89 Methylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Methylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
Q105 Methylation UniProt 24352239
K119 Acetylation PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PRO   PhosphoSitePlus   UniProt 18400894, 25470042, 16359901, ...15386022, 16702407
T121 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231, 18669648, 24140421, ...15078818
S123 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 20068231
K125 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044998 (hHIST2H2AC/InitMet-/Ac:1) acK6 PRO 17709392
PR:000044999 (hHIST2H2AC/InitMet-/Ubiq:1) ubK120 PRO 15386022, 18400894
PR:000045000 (hHIST2H2AC/InitMet-/Phos:1) pS2 PRO 15010469
PR:000045002 (hHIST2H2AC/InitMet-/Ac:2) acK10 PRO 12937907, 18552846
PR:000047842 (hHIST2H2AC/InitMet-/N6AcLys+) ac PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 C2 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S20 P20 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R30 P30 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]
R30 Q30 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ tcga ]
Y51 C51 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R72 L72 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
R82 P82 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
R89 P89 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K96 M96 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T102 S102 Biomuta DOID:3070 / malignant glioma [ cosmic ]
T102 A102 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T102 I102 Biomuta DOID:10534 / stomach cancer [ tcga ]
Q105 E105 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
Q105 H105 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ] DOID:11934 / head and neck cancer [ icgc, tcga ]
K119 E119 Biomuta DOID:1324 / lung cancer [ cosmic ]
K119 N119 Biomuta DOID:1324 / lung cancer [ cosmic ]
T121 N121 Biomuta DOID:1324 / lung cancer [ icgc, tcga ]
T121 I121 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ] DOID:2531 / hematologic cancer [ icgc ]
K125 E125 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K125 * Biomuta DOID:2531 / hematologic cancer [ icgc ]