iPTMnet Report for Q16777 (H2AC20)
Protein Information
| UniProt AC / UniProt ID | Q16777 / H2A2C_HUMAN |
| Protein Name | Histone H2A type 2-C |
| Gene Name | Name: H2AC20 Synonyms:H2AFQ,HIST2H2AC; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q16777 |
| PRO Name | histone H2A type 2-C (human) |
| Definition | A histone H2A type 2-C that is encoded in the genome of human. |
| Short Label | hH2AC20 |
| Category | organism-gene |
DAG ViewQ16777 (H2AC20) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Acetylation | score1 | PRO | ||||
| S2 | Acetylation | score3 | UniProt | 15823041, 16457589 | ||
| S2 | Phosphorylation | score1 | PRO | 15010469 | ||
| K6 | Acetylation | score4 | PRO UniProt | 17709392, 16457589 | ||
| K10 | Acetylation | score1 | PRO | 18552846, 12937907 | ||
| K14 | Ubiquitination | score1 | UniProt | 22713238, 22980979 | ||
| K16 | Ubiquitination | score1 | UniProt | 22713238, 22980979 | ||
| S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Q105 | Methylation | score1 | UniProt | 24352239 | ||
| K119 | Acetylation | score1 | PhosphoSitePlus | |||
| K119 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K120 | Ubiquitination | score2 | PRO UniProt | 18400894, 16359901, 15386022, ... | ||
| T121 | Phosphorylation | score2 | HPRD UniProt | 24140421, 18669648, 15078818, ... | ||
| S123 | Phosphorylation | score2 | HPRD UniProt | 18669648, 20068231 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000044998 (hHIST2H2AC/InitMet-/Ac:1) | acK6 | PRO | 17709392 | ||
| PR:000044999 (hHIST2H2AC/InitMet-/Ubiq:1) | ubK120 | PRO | 15386022, 18400894 | ||
| PR:000045000 (hHIST2H2AC/InitMet-/Phos:1) | pS2 | PRO | 15010469 | ||
| PR:000045002 (hHIST2H2AC/InitMet-/Ac:2) | acK10 | PRO | 12937907, 18552846 | ||
| PR:000047842 (hHIST2H2AC/InitMet-/N6AcLys+) | ac | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S2 | C2 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
| S19 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| Q105 | E105 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| Q105 | H105 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] | |
| K119 | R119 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K119 | N119 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K119 | E119 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| T121 | N121 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| T121 | I121 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
