Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16740 / CLPP_HUMAN
Protein Name ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor
Gene Name Name: CLPP
Organism Homo sapiens (Human)

PRO ID PR:Q16740
DAG View
PRO Name ATP-dependent Clp protease proteolytic subunit, mitochondrial (human)
Definition An ATP-dependent Clp protease proteolytic subunit, mitochondrial that is encoded in the genome of human.
Short Label hCLPP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16740 (CLPP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S169 Phosphorylation HPRD   PhosphoSitePlus 20068231
S173 Phosphorylation HPRD   PhosphoSitePlus 20068231
S181 Phosphorylation PhosphoSitePlus
T189 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K211 Acetylation PhosphoSitePlus   UniProt 19608861
K211 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
T277 Phosphorylation HPRD   PhosphoSitePlus 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S169 L169 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S173 Y173 Biomuta DOID:0070003 / blastoma [ cosmic ]
S181 L181 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]