iPTMnet Report for Q16706 (MAN2A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16706 / MA2A1_HUMAN
Protein Name Alpha-mannosidase 2
Gene Name Name: MAN2A1
Synonyms:MANA2;
Organism Homo sapiens (Human)

PRO ID PR:Q16706
DAG View
PRO Name alpha-mannosidase 2 (human)
Definition An alpha-mannosidase 2 that is encoded in the genome of human.
Short Label hMAN2A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16706 (MAN2A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C16 Methylation IEDB 31844290
Y33 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
N78 N-Glycosylation GlyGen   UniProt 16335952, 29391424, 24190977
S80 O-Glycosylation GlyGen 25813380
S80 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 24275569
S82 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 24275569
S100 O-Glycosylation GlyGen 25813380
S105 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T192 Phosphorylation PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
Y407 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
Y514 Phosphorylation PhosphoSitePlus
Y532 Phosphorylation PhosphoSitePlus
Y533 Phosphorylation PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
Y733 Phosphorylation PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
K739 Ubiquitination PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
T747 Phosphorylation PhosphoSitePlus
K801 Ubiquitination PhosphoSitePlus
Y852 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
K887 Ubiquitination PhosphoSitePlus
S998 Phosphorylation PhosphoSitePlus
N1125 N-Glycosylation GlyGen   UniProt 16335952


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y33 C33 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T192 I192 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y194 H194 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y533 D533 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K737 N737 Biomuta DOID:363 / uterine cancer [ icgc ]
S998 L998 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N1125 D1125 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]