iPTMnet Report for Q16690 (DUSP5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16690 / DUS5_HUMAN
Protein Name Dual specificity protein phosphatase 5
Gene Name Name: DUSP5
Synonyms:VH3;
Organism Homo sapiens (Human)

PRO ID PR:Q16690
DAG View
PRO Name dual specificity protein phosphatase 5 (human)
Definition A dual specificity protein phosphatase 5 that is encoded in the genome of human.
Short Label hDUSP5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16690 (DUSP5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Ubiquitination PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
T110 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
C197 Methylation IEDB 31844290
K258 Ubiquitination PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
T321 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   PhosphoSitePlus   RLIMS-P 19666109
S346 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   PhosphoSitePlus   RLIMS-P 19666109
C354 Methylation IEDB 31844290
S376 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   PhosphoSitePlus   RLIMS-P 19666109


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K144 N144 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
C197 G197 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y277 C277 Biomuta DOID:3571 / liver cancer [ cosmic ]
K294 Q294 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S346 N346 Biomuta DOID:10534 / stomach cancer [ cosmic ]