iPTMnet Report for Q16666 (IFI16)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16666 / IF16_HUMAN
Protein Name Gamma-interferon-inducible protein 16
Gene Name Name: IFI16
Synonyms:IFNGIP1;
Organism Homo sapiens (Human)

PRO ID PR:Q16666
DAG View
PRO Name gamma-interferon-inducible protein 16 (human)
Definition A gamma-interferon-inducible protein 16 that is encoded in the genome of human.
Short Label hIFI16
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16666 (IFI16) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Ubiquitination PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
Y20 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K45 Acetylation PhosphoSitePlus   UniProt 22691496
K55 Ubiquitination PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K83 Sumoylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus   UniProt 22691496
K99 Acetylation PhosphoSitePlus   UniProt 22691496
K99 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus
S106 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 22691496, ...18669648, 24275569, 19690332, 20068231
S110 Phosphorylation PhosphoSitePlus
K116 Sumoylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
T117 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus   UniProt 22691496
K128 Ubiquitination PhosphoSitePlus
S132 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 11115400
S132 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 11115400
S142 Phosphorylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
S153 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 19690332, ...18669648, 24275569, 22691496, 20068231
S160 Phosphorylation PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
S166 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S168 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 22691496
S174 Phosphorylation PhosphoSitePlus   UniProt 22691496
N178 N-Glycosylation GlyGen 29741879
K190 Sumoylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
K214 Acetylation PhosphoSitePlus   UniProt 19608861, 22691496
K214 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
Y317 Phosphorylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
T332 Phosphorylation PhosphoSitePlus
Y334 Phosphorylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
C356 Methylation IEDB 31844290
K361 Ubiquitination PhosphoSitePlus
K377 Acetylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K400 Acetylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
T428 Phosphorylation PhosphoSitePlus
T434 Phosphorylation PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
K443 Methylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K444 Acetylation PhosphoSitePlus   UniProt 22691496
K444 Sumoylation PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K451 Acetylation PhosphoSitePlus   UniProt 22691496
K451 Sumoylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
T484 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
T491 Phosphorylation PhosphoSitePlus
K500 Sumoylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K507 Sumoylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
T540 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K561 Acetylation PhosphoSitePlus   UniProt 22691496
K561 Sumoylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
T562 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus   UniProt 20068231
K598 Acetylation PhosphoSitePlus   UniProt 22691496
K598 Sumoylation PhosphoSitePlus
K614 Acetylation PhosphoSitePlus   UniProt 22691496
K614 Ubiquitination PhosphoSitePlus
K621 Acetylation PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
K683 Sumoylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
Y704 Phosphorylation PhosphoSitePlus
K732 Acetylation PhosphoSitePlus
K732 Sumoylation PhosphoSitePlus
K732 Ubiquitination PhosphoSitePlus
K734 Acetylation PhosphoSitePlus
K734 Sumoylation PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
K743 Sumoylation PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
K759 Acetylation PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
S775 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S776 Phosphorylation PhosphoSitePlus
T779 Phosphorylation PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus   UniProt 22691496
Site PTM Type PTM Enzyme Score Source PMID
S106 Phosphorylation HPRD 18767875, 18669648, 16964243, ...20068231
S132 Phosphorylation HPRD 11115400
S132 Phosphorylation P68400 (CSNK2A1) HPRD 11115400
S153 Phosphorylation HPRD 15302935, 20058876, 18452278, ...18669648, 19415658, 20068231
S166 Phosphorylation HPRD 18669648
S168 Phosphorylation HPRD 18669648
S519 Phosphorylation HPRD 20068231
S719 Phosphorylation HPRD 18669648
S720 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K443 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K6 E6 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K34 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K34 N34 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K55 N55 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K64 E64 Biomuta DOID:1612 / breast cancer [ icgc ]
K67 Q67 Biomuta DOID:363 / uterine cancer [ icgc ]
K90 Q90 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S95 L95 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S106 L106 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S110 A110 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K116 Q116 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T117 P117 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S132 P132 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S142 G142 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K143 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S160 T160 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
N178 S178 Biomuta DOID:3565 / meningioma [ cosmic ]
K202 I202 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S211 R211 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K250 N250 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K303 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S437 F437 Biomuta DOID:4159 / skin cancer [ cosmic ]
T484 P484 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S536 R536 Biomuta DOID:1324 / lung cancer [ cosmic ]
T562 S562 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S572 N572 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
K614 M614 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K732 I732 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T779 S779 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]