iPTMnet Report Q16665 HIF1A

Protein Information

UniProt AC / UniProt ID	Q16665 / HIF1A_HUMAN
Protein Name	Hypoxia-inducible factor 1-alpha
Gene Name	Name: HIF1A Synonyms:BHLHE78,MOP1;
Organism	Homo sapiens (Human)

PRO ID	PR:Q16665 DAG View
PRO Name	hypoxia-inducible factor 1-alpha (human)
Definition	A hypoxia-inducible factor 1-alpha that is encoded in the genome of human.
Short Label	hHIF1A
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q16665 (HIF1A) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K10 K11 K12 K19 K21 S31 K32 T63 Y66 K71 K85 S113 K172 C173 K185 C219 S247 K251 C255 R258 K289 K297 K377 K389 K391 P402 S451 T455 T458 K460 S465 K477 C520 K532 K538 K547 S551 T555 P564 Y565 S576 S589 K636 S641 S643 K649 T651 T652 S653 S656 S657 S668 K674 K682 S683 S687 S692 S696 T700 K709 K721 S727 S760 S761 K769 C780 T796 S797 C800 S809	PTM Type Select all Acetylation Dihydroxylation Methylation Phosphorylation S-Nitrosylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all IEDB IntAct PRO PhosphoSitePlus RLIMS-P RLIMS-P+ Signor UniProt dbSNO neXtProt phospho.ELM	PMID
K10	Acetylation		score1	PhosphoSitePlus
K10	Sumoylation		score1	PhosphoSitePlus
K11	Acetylation		score1	PhosphoSitePlus
K12	Acetylation		score1	PhosphoSitePlus
K19	Acetylation		score1	PhosphoSitePlus
K21	Acetylation		score1	PhosphoSitePlus
S31	Phosphorylation		score1	PhosphoSitePlus
K32	Methylation		score1	PhosphoSitePlus
K32	Ubiquitination		score1	PhosphoSitePlus
T63	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	27245613
Y66	Phosphorylation		score1	PhosphoSitePlus
K71	Ubiquitination		score1	PhosphoSitePlus
K85	Ubiquitination		score1	PhosphoSitePlus
S113	Phosphorylation		score1	PhosphoSitePlus
K172	Ubiquitination		score1	PhosphoSitePlus
C173	Methylation		score1	IEDB	31844290
K185	Sumoylation		score1	PhosphoSitePlus
K185	Ubiquitination		score1	PhosphoSitePlus
C219	Methylation		score1	IEDB	31844290
S247	Phosphorylation	P48730 (CSNK1D)	score4	PhosphoSitePlus RLIMS-P Signor UniProt	20699359, 36027865
K251	Ubiquitination		score1	PhosphoSitePlus
C255	Methylation		score1	IEDB	31844290
R258	Methylation		score1	PhosphoSitePlus
K289	Ubiquitination		score1	PhosphoSitePlus
K297	Ubiquitination		score1	PhosphoSitePlus
K377	Sumoylation		score1	PhosphoSitePlus
K377	Ubiquitination		score1	PhosphoSitePlus
K389	Acetylation		score1	PhosphoSitePlus
K389	Ubiquitination		score1	PhosphoSitePlus
K391	Methylation		score1	PhosphoSitePlus
K391	Sumoylation		score1	PhosphoSitePlus
K391	Ubiquitination		score1	PhosphoSitePlus
P402	Dihydroxylation		score2	IntAct	17986458
S451	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	33550096
T455	Phosphorylation		score1	PhosphoSitePlus
T458	Phosphorylation		score1	PhosphoSitePlus
K460	Ubiquitination		score1	PhosphoSitePlus
S465	Phosphorylation		score1	PhosphoSitePlus
K477	Sumoylation		score1	PhosphoSitePlus
K477	Ubiquitination		score1	PhosphoSitePlus
C520	S-Nitrosylation		score2	dbSNO	22178444, 17434127
K532	Acetylation		score3	PhosphoSitePlus UniProt	24681946
K532	Ubiquitination		score3	PhosphoSitePlus UniProt	16862177
K538	Ubiquitination		score3	PhosphoSitePlus UniProt	16862177
K547	Ubiquitination		score3	PhosphoSitePlus UniProt	16862177
S551	Phosphorylation		score3	PhosphoSitePlus UniProt	20889502
T555	Phosphorylation		score3	PhosphoSitePlus UniProt	20889502
P564	Dihydroxylation		score2	IntAct	17986458
Y565	Phosphorylation		score2	PRO PhosphoSitePlus
S576	Phosphorylation	Q9H4B4 (PLK3)	score4	neXtProt PhosphoSitePlus Signor UniProt	18519666, 20889502
S589	Phosphorylation		score3	PhosphoSitePlus UniProt	20889502
K636	Ubiquitination		score1	PhosphoSitePlus
S641	Phosphorylation	P27361 (MAPK3) , P28482 (MAPK1)	score4	neXtProt PhosphoSitePlus RLIMS-P Signor	18519666, 18687685, 16954218
S643	Phosphorylation	P28482 (MAPK1) , P27361 (MAPK3)	score4	neXtProt PhosphoSitePlus RLIMS-P Signor	18519666, 18687685, 16954218
K649	Ubiquitination		score1	PhosphoSitePlus
T651	Phosphorylation		score1	PhosphoSitePlus
T652	Phosphorylation		score1	PhosphoSitePlus
S653	Phosphorylation		score1	PhosphoSitePlus
S656	Phosphorylation		score1	PhosphoSitePlus
S657	Phosphorylation	Q9H4B4 (PLK3)	score4	neXtProt PhosphoSitePlus Signor UniProt	18519666, 20889502
S668	Phosphorylation	P06493 (CDK1)	score4	IEDB PhosphoSitePlus RLIMS-P	24189531, 27869121
K674	Acetylation		score1	PhosphoSitePlus
K674	Ubiquitination		score1	PhosphoSitePlus
K682	Ubiquitination		score1	PhosphoSitePlus
S683	Phosphorylation		score1	PhosphoSitePlus
S687	Phosphorylation		score4	IEDB PhosphoSitePlus RLIMS-P	27027353, 30784271, 33936100, ...27920218
S692	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	27245613
S696	Phosphorylation	Q13315 (ATM)	score3	neXtProt PhosphoSitePlus RLIMS-P Signor	21095582
T700	Phosphorylation		score1	PhosphoSitePlus
K709	Acetylation		score3	PhosphoSitePlus UniProt	24681946
K709	Ubiquitination		score1	PhosphoSitePlus
K721	Ubiquitination		score1	PhosphoSitePlus
S727	Phosphorylation		score1	PhosphoSitePlus
S760	Phosphorylation		score1	PhosphoSitePlus
S761	Phosphorylation		score1	PhosphoSitePlus
K769	Ubiquitination		score1	PhosphoSitePlus
C780	Methylation		score1	IEDB	31844290
T796	Phosphorylation		score3	phospho.ELM PhosphoSitePlus	11983697
S797	Phosphorylation	Q5S007 (LRRK2)	score3	PRO RLIMS-P+	26751287
C800	S-Nitrosylation		score2	dbSNO	22178444, 15688001, 15023551
S809	Phosphorylation		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid All Threonine By position T796	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all HPRD	PMID
	T796	Phosphorylation	P68400 (CSNK2A1)	score1	HPRD	17382325

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000047696 (hHIF1A/Phos:2)	Sites Select all pY565,pS797	PTM Enzyme	Source Select all PRO	PMID
	PR:000047696 (hHIF1A/Phos:2)	pY565,pS797		PRO

Proteoform PPIs

Search:

	Protein 1 Select all PR:Q92793-1 (hCREBBP/iso:1)	Relation Select all Interaction	Protein 2 Select all PR:Q16665 (hHIF1A)	Source Select all PRO	PMID
	PR:Q92793-1 (hCREBBP/iso:1)	Interaction	PR:Q16665 (hHIF1A)	PRO	9887100

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K10 K19 Y66 C219 K377 K391 T455 K477 K547 P564 K636 K682 S692 K721 S727 K769 S809	Variant Select all * A564 C66 F219 N10 N377 N547 N636 N721 N769 N809 Q19 Q682 R391 S455 T477 Y692	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:1793 / pancreatic cancer [ icgc ] DOID:184 / bone cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ icgc ]
K10	N10	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
K19	Q19	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
Y66	C66	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
C219	F219	Biomuta	DOID:3571 / liver cancer [ cosmic ]
K377	N377	Biomuta	DOID:9256 / colorectal cancer [ icgc ]
K391	R391	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T455	S455	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
K477	T477	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
K547	N547	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
P564	A564	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
K636	N636	Biomuta	DOID:184 / bone cancer [ cosmic ]
K682	Q682	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S692	Y692	Biomuta	DOID:1793 / pancreatic cancer [ icgc ]
K721	N721	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S727	*	Biomuta	DOID:263 / kidney cancer [ cosmic ]
K769	N769	Biomuta	DOID:9256 / colorectal cancer [ icgc ]
S809	N809	Biomuta	DOID:3571 / liver cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q16665 (HIF1A)

Protein Information

Interactive Sequence View

Q16665 (HIF1A) as Substrate

Proteoforms

Proteoform PPIs

PTM sites affected in variants