iPTMnet Report for Q16659 (MAPK6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16659 / MK06_HUMAN
Protein Name Mitogen-activated protein kinase 6
Gene Name Name: MAPK6
Synonyms:ERK3,PRKM6;
Organism Homo sapiens (Human)

PRO ID PR:Q16659
DAG View
PRO Name mitogen-activated protein kinase 6 (human)
Definition A mitogen-activated protein kinase 6 that is encoded in the genome of human.
Short Label hMAPK6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16659 (MAPK6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Ubiquitination PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
S189 Phosphorylation Q16659 (MAPK6) , Q13177 (PAK2) , O75914 (PAK3) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 21177870, 23186163, ...11741894, 21317288, 19651622, 18669648, 32314963, 8621539, 1741894, 33070159
K195 Ubiquitination PhosphoSitePlus
Y209 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
Y357 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S386 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19664994, 18669648, 23186163
T389 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K408 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y453 Phosphorylation PhosphoSitePlus
Y467 Phosphorylation PhosphoSitePlus
Y468 Phosphorylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus   UniProt 23186163
S558 Phosphorylation PhosphoSitePlus   UniProt 23186163
K563 Ubiquitination PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
T644 Phosphorylation PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
S665 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K672 Ubiquitination PhosphoSitePlus
S684 Phosphorylation P06493 (CDK1) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20236090, 23186163
S688 Phosphorylation P06493 (CDK1) PRO   PhosphoSitePlus   RLIMS-P   Signor 20236090
K691 Ubiquitination PhosphoSitePlus
T698 Phosphorylation P06493 (CDK1) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor 20236090
K703 Ubiquitination PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
S705 Phosphorylation P06493 (CDK1) PRO   PhosphoSitePlus   RLIMS-P   Signor 20236090


Q16659 (MAPK6) as PTM Enzyme



Substrate Site Score Source PMID
O95551 (TDP2) S60 PhosphoSitePlus 26701725
P46695 (IER3) T18 phospho.ELM 12356731
Q16659 (MAPK6) S189 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19651622, 18669648, 11741894, ...8621539
Q8IW41 (MAPKAPK5) T182 neXtProt 15577943, 19473979
Q9Y6Q9 (NCOA3) S857 neXtProt   PhosphoSitePlus   Signor 22505454


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048324 (hMAPK6/Phos:1) pS189 PRO
PR:000048325 (hMAPK6/Phos:2) pS684,pS688,pT698,pS705 PRO