iPTMnet Report for Q16658 (FSCN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16658 / FSCN1_HUMAN
Protein Name Fascin
Gene Name Name: FSCN1
Synonyms:FAN1,HSN,SNL;
Organism Homo sapiens (Human)

PRO ID PR:Q16658
DAG View
PRO Name fascin (human)
Definition A fascin that is encoded in the genome of human.
Short Label hFSCN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16658 (FSCN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 22223895
Y23 Phosphorylation PhosphoSitePlus   RLIMS-P 28251354
S38 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 28251354, 20068231
S39 Phosphorylation P17252 (PRKCA) , Q05655 (PRKCD) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27554857, 20713986, 8999969, ...32294157, 22564415, 19651622, 22155786, 29299131, 20137952, 20068231, 30664308, 12789270, 8647875, 28251354
K41 Acetylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K43 Acetylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
C80 S-Nitrosylation dbSNO 26338901
Y111 Phosphorylation PhosphoSitePlus
R118 Methylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
C121 Methylation IEDB 31844290
S127 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y145 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus
R217 Methylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus   UniProt 23186163
S237 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus   UniProt 23186163
K241 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
C260 Methylation IEDB 31844290
S274 Phosphorylation PhosphoSitePlus   RLIMS-P 28251354
K304 Acetylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
Y314 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
K353 Methylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
C397 Methylation IEDB 31844290
C397 S-Nitrosylation dbSNO 19483679
K399 Sumoylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
T403 Phosphorylation PhosphoSitePlus
Y411 Phosphorylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
Y432 Phosphorylation PhosphoSitePlus
T447 Phosphorylation PhosphoSitePlus
Y458 Phosphorylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K471 Acetylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
T484 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q16658 (FSCN1) S39 Q8WXH0 (SYNE2) increased_association eFIP 28060557
Phosphorylation Q16658 (FSCN1) S39 Q96PY5 (FMNL2) increased_association eFIP 32294157


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K43 R43 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R118 H118 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
C121 R121 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R217 C217 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S218 F218 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S237 N237 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
K313 R313 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K353 N353 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]