iPTMnet Report Q16658 FSCN1

Protein Information

UniProt AC / UniProt ID	Q16658 / FSCN1_HUMAN
Protein Name	Fascin
Gene Name	Name: FSCN1 Synonyms:FAN1,HSN,SNL;
Organism	Homo sapiens (Human)

PRO ID	PR:Q16658 DAG View
PRO Name	fascin (human)
Definition	A fascin that is encoded in the genome of human.
Short Label	hFSCN1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q16658 (FSCN1) as Substrate

Q16658

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position T2 Y23 S38 S39 K41 K42 K43 Y69 K74 T79 C80 Y111 R118 S120 C121 S127 Y145 S146 T148 R217 S218 S234 S237 T239 K241 K247 K250 C260 S274 K304 K313 Y314 S333 K353 K359 C397 K399 T403 Y411 K426 Y432 T447 Y458 K464 K471 K479 T484	PTM Type Select all Acetylation Methylation Phosphorylation S-Nitrosylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 3 4	Source Select all HPRD IEDB PhosphoSitePlus RLIMS-P Signor UniProt dbSNO phospho.ELM	PMID
T2	Acetylation		score1	UniProt	22223895
Y23	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	28251354
S38	Phosphorylation		score4	HPRD phospho.ELM PhosphoSitePlus RLIMS-P UniProt	18669648, 28251354, 20068231
S39	Phosphorylation	P17252 (PRKCA) , Q05655 (PRKCD)	score4	HPRD phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	27554857, 20713986, 8999969, ...32294157, 22564415, 19651622, 22155786, 29299131, 20137952, 20068231, 30664308, 12789270, 8647875, 28251354
K41	Acetylation		score1	PhosphoSitePlus
K41	Ubiquitination		score1	PhosphoSitePlus
K42	Ubiquitination		score1	PhosphoSitePlus
K43	Acetylation		score1	PhosphoSitePlus
K43	Ubiquitination		score1	PhosphoSitePlus
Y69	Phosphorylation		score1	PhosphoSitePlus
K74	Acetylation		score1	PhosphoSitePlus
K74	Ubiquitination		score1	PhosphoSitePlus
T79	Phosphorylation		score1	PhosphoSitePlus
C80	S-Nitrosylation		score0	dbSNO	26338901
Y111	Phosphorylation		score1	PhosphoSitePlus
R118	Methylation		score1	PhosphoSitePlus
S120	Phosphorylation		score1	PhosphoSitePlus
C121	Methylation		score1	IEDB	31844290
S127	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
Y145	Phosphorylation		score1	PhosphoSitePlus
S146	Phosphorylation		score1	PhosphoSitePlus
T148	Phosphorylation		score1	PhosphoSitePlus
R217	Methylation		score1	PhosphoSitePlus
S218	Phosphorylation		score1	PhosphoSitePlus
S234	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S237	Phosphorylation		score1	PhosphoSitePlus
T239	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K241	Ubiquitination		score1	PhosphoSitePlus
K247	Ubiquitination		score1	PhosphoSitePlus
K250	Acetylation		score1	PhosphoSitePlus
K250	Ubiquitination		score1	PhosphoSitePlus
C260	Methylation		score1	IEDB	31844290
S274	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	28251354
K304	Acetylation		score1	PhosphoSitePlus
K313	Ubiquitination		score1	PhosphoSitePlus
Y314	Phosphorylation		score1	PhosphoSitePlus
S333	Phosphorylation		score1	PhosphoSitePlus
K353	Acetylation		score1	PhosphoSitePlus
K353	Methylation		score1	PhosphoSitePlus
K353	Ubiquitination		score1	PhosphoSitePlus
K359	Ubiquitination		score1	PhosphoSitePlus
C397	Methylation		score1	IEDB	31844290
C397	S-Nitrosylation		score0	dbSNO	19483679
K399	Sumoylation		score1	PhosphoSitePlus
K399	Ubiquitination		score1	PhosphoSitePlus
T403	Phosphorylation		score1	PhosphoSitePlus
Y411	Phosphorylation		score1	PhosphoSitePlus
K426	Ubiquitination		score1	PhosphoSitePlus
Y432	Phosphorylation		score1	PhosphoSitePlus
T447	Phosphorylation		score1	PhosphoSitePlus
Y458	Phosphorylation		score1	PhosphoSitePlus
K464	Ubiquitination		score1	PhosphoSitePlus
K471	Acetylation		score1	PhosphoSitePlus
K471	Ubiquitination		score1	PhosphoSitePlus
K479	Ubiquitination		score1	PhosphoSitePlus
T484	Phosphorylation		score1	PhosphoSitePlus

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all Q16658 (FSCN1)	Site Select all By amino acid All Serine By position S39	Interactant Select all Q8WXH0 (SYNE2) Q96PY5 (FMNL2)	Association type Select all increased_association	Source Select all eFIP	PMID
	Phosphorylation	Q16658 (FSCN1)	S39	Q8WXH0 (SYNE2)	increased_association	eFIP	28060557
	Phosphorylation	Q16658 (FSCN1)	S39	Q96PY5 (FMNL2)	increased_association	eFIP	32294157

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine By position K43 R118 C121 R217 S218 S237 K313 K353	Variant Select all C217 F218 H118 N237 N353 R121 R313 R43	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
K43	R43	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R118	H118	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
C121	R121	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R217	C217	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S218	F218	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
S237	N237	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
K313	R313	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
K353	N353	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q16658 (FSCN1)

Protein Information

Interactive Sequence View

Q16658 (FSCN1) as Substrate

PTM-dependent PPI

PTM sites affected in variants