iPTMnet Report for Q16654 (PDK4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16654 / PDK4_HUMAN
Protein Name [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial precursor
Gene Name Name: PDK4
Synonyms:PDHK4;
Organism Homo sapiens (Human)

PRO ID PR:Q16654
DAG View
PRO Name [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (human)
Definition A [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial that is encoded in the genome of human.
Short Label hPDK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16654 (PDK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus


Q16654 (PDK4) as PTM Enzyme



Substrate Site Score Source PMID
P08559 (PDHA1) S293 HPRD   neXtProt   PhosphoSitePlus 18691976, 18212344, 18767875, ...11486000, 19081061, 20166139, 12676647, 11485553, 19415658, 16436377
P08559-1 (PDHA1) S300 HPRD   neXtProt   PhosphoSitePlus   Signor 18691976, 18212344, 16436377, ...11486000, 17474719, 20166139, 11485553, 19415658, 12676647
P29803 (PDHA2) S291 neXtProt   PhosphoSitePlus   Signor 14966024, 16436377
P29803 (PDHA2) S298 PhosphoSitePlus 16436377


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S13 L13 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K374 E374 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]