Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16644 / MAPK3_HUMAN
Protein Name MAP kinase-activated protein kinase 3
Gene Name Name: MAPKAPK3
Organism Homo sapiens (Human)

PRO ID PR:Q16644
DAG View
PRO Name MAP kinase-activated protein kinase 3 (human)
Definition A MAP kinase-activated protein kinase 3 that is encoded in the genome of human.
Short Label hMAPKAPK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16644 (MAPKAPK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
T5 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
Y204 Phosphorylation HPRD   PhosphoSitePlus 15592455
T205 Phosphorylation PhosphoSitePlus
Y207 Phosphorylation HPRD   PhosphoSitePlus 15592455
Y208 Phosphorylation HPRD   PhosphoSitePlus 15592455
S244 Phosphorylation HPRD   PhosphoSitePlus 20058876
T246 Phosphorylation HPRD   PhosphoSitePlus 20058876
S251 Phosphorylation HPRD   PhosphoSitePlus 20058876
K286 Ubiquitination PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
T313 Phosphorylation PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
K332 Acetylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus


Q16644 (MAPKAPK3) as PTM Enzyme





PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K179 R179 Biomuta DOID:169 / neuroendocrine tumor [ tcga ]
S251 F251 Biomuta DOID:1909 / melanoma [ icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]
S307 L307 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S373 Y373 Biomuta DOID:4362 / cervical cancer [ tcga ]