iPTMnet Report for Q16644 (MAPKAPK3)
Protein Information
UniProt AC / UniProt ID | Q16644 / MAPK3_HUMAN |
Protein Name | MAP kinase-activated protein kinase 3 |
Gene Name | Name: MAPKAPK3 |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q16644 |
PRO Name | MAP kinase-activated protein kinase 3 (human) |
Definition | A MAP kinase-activated protein kinase 3 that is encoded in the genome of human. |
Short Label | hMAPKAPK3 |
Category | organism-gene |
Q16644 (MAPKAPK3) as Substrate
Site | PTM Type | PTM Enzyme |
Score
| Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 19413330, 22814378 | ||
T5 | Phosphorylation | score1 | PhosphoSitePlus | |||
K36 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y43 | Phosphorylation | score1 | PhosphoSitePlus | |||
K47 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y76 | Phosphorylation | score1 | PhosphoSitePlus | |||
K168 | Ubiquitination | score1 | PhosphoSitePlus | |||
K177 | Acetylation | score1 | PhosphoSitePlus | |||
K179 | Acetylation | score1 | PhosphoSitePlus | |||
K184 | Ubiquitination | score1 | PhosphoSitePlus | |||
K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
T201 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y204 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15592455 | ||
T205 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y207 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15592455 | ||
Y208 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15592455 | ||
S244 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20058876 | ||
T246 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20058876 | ||
S251 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20058876 | ||
K286 | Ubiquitination | score1 | PhosphoSitePlus | |||
S307 | Phosphorylation | score1 | PhosphoSitePlus | |||
T313 | Phosphorylation | score1 | PhosphoSitePlus | |||
T317 | Phosphorylation | score1 | PhosphoSitePlus | |||
K325 | Ubiquitination | score1 | PhosphoSitePlus | |||
K332 | Acetylation | score1 | PhosphoSitePlus | |||
K332 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y346 | Phosphorylation | score1 | PhosphoSitePlus | |||
K350 | Ubiquitination | score1 | PhosphoSitePlus | |||
S372 | Phosphorylation | score1 | PhosphoSitePlus | |||
S373 | Phosphorylation | score1 | PhosphoSitePlus | |||
S374 | Phosphorylation | score1 | PhosphoSitePlus | |||
S376 | Phosphorylation | score1 | PhosphoSitePlus |
Q16644 (MAPKAPK3) as PTM Enzyme
Substrate | Site | Score | Source | PMID | |
---|---|---|---|---|---|
O00418 (EEF2K) | S377 | score3 | HPRD neXtProt | 12171600 | |
P04792 (HSPB1) | S15 | score4 | HPRD neXtProt | 18691976, 18088087, 18212344, ...20230923, 1332886, 18767875, 21575178, 19007248, 8626550, 19651622, 19664994, 18669648, 20068231, 20058876, 20166139, 16565220, 19562805 | |
P04792 (HSPB1) | S78 | score4 | HPRD neXtProt | 18212344, 1332886, 18767875, ...20058876, 8626550, 21575178, 20068231 | |
P04792 (HSPB1) | S82 | score4 | HPRD neXtProt | 18578522, 16964243, 19562805, ...18707149, 18691976, 18212344, 21575178, 19691289, 16565220, 18088087, 18767875, 20058876, 19007248, 8626550, 19651622, 1332886, 19664994, 19664995, 18669648, 20166139, 19415658, 20068231, 17924679 | |
Q14457 (BECN1) | S90 | score2 | PhosphoSitePlus | 25693418 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K184 | N184 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S244 | Y244 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T246 | M246 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S251 | F251 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] | |
S307 | L307 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T317 | M317 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
S373 | Y373 | Biomuta | DOID:4362 / cervical cancer [ cosmic ] | |
S376 | L376 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
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