iPTMnet Report for Q16644 (MAPKAPK3)
Protein Information
| UniProt AC / UniProt ID | Q16644 / MAPK3_HUMAN |
| Protein Name | MAP kinase-activated protein kinase 3 |
| Gene Name | Name: MAPKAPK3 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q16644 |
| PRO Name | MAP kinase-activated protein kinase 3 (human) |
| Definition | A MAP kinase-activated protein kinase 3 that is encoded in the genome of human. |
| Short Label | hMAPKAPK3 |
| Category | organism-gene |
DAG ViewQ16644 (MAPKAPK3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 19413330, 22814378 | ||
| T5 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K36 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y43 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K47 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y76 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K168 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K177 | Acetylation | score1 | PhosphoSitePlus | |||
| K179 | Acetylation | score1 | PhosphoSitePlus | |||
| K184 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T201 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y204 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15592455 | ||
| T205 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y207 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15592455 | ||
| Y208 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15592455 | ||
| S244 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20058876 | ||
| T246 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20058876 | ||
| S251 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20058876 | ||
| K286 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S307 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T313 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T317 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K325 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K332 | Acetylation | score1 | PhosphoSitePlus | |||
| K332 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y346 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K350 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S372 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S373 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S374 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S376 | Phosphorylation | score1 | PhosphoSitePlus |
Q16644 (MAPKAPK3) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O00418 (EEF2K) | S377 | score3 | HPRD neXtProt | 12171600 | |
| P04792 (HSPB1) | S15 | score4 | HPRD neXtProt | 18691976, 18088087, 18212344, ... | |
| P04792 (HSPB1) | S78 | score4 | HPRD neXtProt | 18212344, 1332886, 18767875, ... | |
| P04792 (HSPB1) | S82 | score4 | HPRD neXtProt | 18578522, 16964243, 19562805, ... | |
| Q14457 (BECN1) | S90 | score2 | PhosphoSitePlus | 25693418 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K184 | N184 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S244 | Y244 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T246 | M246 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S251 | F251 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] | |
| S307 | L307 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T317 | M317 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| S373 | Y373 | Biomuta | DOID:4362 / cervical cancer [ cosmic ] | |
| S376 | L376 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
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