Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16643 / DREB_HUMAN
Protein Name Drebrin
Gene Name Name: DBN1
Synonyms:D0S117E;
Organism Homo sapiens (Human)

PRO ID PR:Q16643
DAG View
PRO Name drebrin (human)
Definition A drebrin that is encoded in the genome of human.
Short Label hDBN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16643 (DBN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 12665801
S5 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
Y65 Phosphorylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
C96 S-Nitrosylation dbSNO 2212679, 22126794
S134 Phosphorylation HPRD   PhosphoSitePlus 20068231
S141 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 18220336, ...23979715, 15302935, 19651622, 18669648, 18088087, 20068231
S142 Phosphorylation Q00535 (CDK5) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18578522, 15659558, 23979715, ...18707149, 21406692, 23186163, 18212344, 18452278, 18088087, 18767875, 19651622, 17287340, 17081983, 15302935, 19664995, 17322306, 18669648, 20166139, 25945928, 19415658, 20068231
T162 Phosphorylation PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
T241 Phosphorylation HPRD   PhosphoSitePlus 20068231
K252 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K295 Acetylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S312 Phosphorylation HPRD   PhosphoSitePlus 20068231
S320 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
T331 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T335 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17081983, 19664995, 18452278, ...19651622, 18669648, 18707149, 19415658, 20068231
S337 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18491316, ...23186163, 17081983, 19664995, 19651622, 18669648, 18707149, 19415658, 20068231
S339 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18491316, ...18088087, 17081983, 16094384, 20058876, 19664995, 18452278, 19651622, 18669648, 18707149, 23186163, 19415658, 20068231
S341 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18088087, 16094384, ...20058876, 19664995, 18452278, 19651622, 18669648, 18707149, 19415658, 20068231
S342 Phosphorylation HPRD   PhosphoSitePlus 18669648, 15345747, 19415658, ...19664995
T343 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18669648, 20068231
S345 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18669648, 19664995
T346 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17287340, 19664995, ...18669648, 23186163, 15345747, 19690332
T377 Phosphorylation HPRD   PhosphoSitePlus 18669648
S381 Phosphorylation HPRD   PhosphoSitePlus 18669648
S416 Phosphorylation PhosphoSitePlus   UniProt 24275569
T497 Phosphorylation PhosphoSitePlus   UniProt 24275569
T559 Phosphorylation PhosphoSitePlus
S564 Phosphorylation HPRD 17081983
S594 Phosphorylation PhosphoSitePlus
Y597 Phosphorylation PhosphoSitePlus
S599 Phosphorylation HPRD   PhosphoSitePlus 19664995
S601 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18077418, 18669648, ...19664995
S609 Phosphorylation PhosphoSitePlus
Y622 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
Site PTM Type PTM Enzyme Score Source PMID
S142 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P17302 (GJA1) Y247 Q16643 (DBN1) inhibited_association eFIP 27280719
Phosphorylation P17302 (GJA1) Y265 Q16643 (DBN1) inhibited_association eFIP 27280719


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T162 N162 Biomuta DOID:263 / kidney cancer [ cosmic ]
S274 L274 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S274 W274 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S312 L312 Biomuta DOID:2394 / ovarian cancer [ tcga ]
S320 R320 Biomuta DOID:3571 / liver cancer [ icgc ]
T335 M335 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S341 F341 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S342 G342 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S345 A345 Biomuta DOID:1909 / melanoma [ cosmic ]
S564 L564 Biomuta DOID:1909 / melanoma [ tcga ]
S601 L601 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]