Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16630 / CPSF6_HUMAN
Protein Name Cleavage and polyadenylation specificity factor subunit 6
Gene Name Name: CPSF6
Synonyms:CFIM68;
Organism Homo sapiens (Human)

PRO ID PR:Q16630
DAG View
PRO Name cleavage and polyadenylation specificity factor subunit 6 (human)
Definition A cleavage and polyadenylation specificity factor subunit 6 that is encoded in the genome of human.
Short Label hCPSF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16630 (CPSF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
T75 Phosphorylation PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
K79 Acetylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
C159 S-Nitrosylation dbSNO 26338901
K161 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S165 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K185 Acetylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
R194 Methylation PhosphoSitePlus
R202 Methylation PhosphoSitePlus
R204 Methylation PhosphoSitePlus
R206 Methylation PhosphoSitePlus
R216 Methylation PhosphoSitePlus
Y384 Phosphorylation PhosphoSitePlus
Y390 Phosphorylation PhosphoSitePlus
R392 Methylation PhosphoSitePlus
Y395 Phosphorylation PhosphoSitePlus
T404 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
T407 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S410 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus   RLIMS-P 30916345
S500 Phosphorylation PhosphoSitePlus   RLIMS-P 30916345
S502 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus   RLIMS-P 30916345
S513 Phosphorylation PhosphoSitePlus   RLIMS-P 30916345
Y520 Phosphorylation PhosphoSitePlus
Y521 Phosphorylation PhosphoSitePlus
S525 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 30916345, 17081983
Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation HPRD 20058876
T55 Phosphorylation HPRD 19664995
S165 Phosphorylation HPRD 17525332
T404 Phosphorylation HPRD 19651622, 19664995, 20068231
T407 Phosphorylation HPRD 18669648, 19664995, 18452278
S410 Phosphorylation HPRD 17081983
S425 Phosphorylation HPRD 18452278
S426 Phosphorylation HPRD 18452278
S427 Phosphorylation HPRD 18452278
S430 Phosphorylation HPRD 18452278
S434 Phosphorylation HPRD 18452278
S437 Phosphorylation HPRD 18452278
S494 Phosphorylation HPRD 20068231
S500 Phosphorylation HPRD 20068231
S513 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
R216 Methylation PhosphoSitePlus
R243 Methylation PhosphoSitePlus
R250 Methylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C159 F159 Biomuta DOID:3571 / liver cancer [ icgc ]
S165 I165 Biomuta DOID:3571 / liver cancer [ icgc ]
R194 C194 Biomuta DOID:1324 / lung cancer [ tcga ]
R204 W204 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R206 H206 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S425 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S425 L425 Biomuta DOID:1324 / lung cancer [ cosmic ]
S430 L430 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S494 T494 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S500 T500 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S500 I500 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:1324 / lung cancer [ cosmic ]
S502 * Biomuta DOID:1909 / melanoma [ cosmic ]
S511 F511 Biomuta DOID:1909 / melanoma [ icgc, tcga ]