iPTMnet Report for Q16621 (NFE2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16621 / NFE2_HUMAN
Protein Name Transcription factor NF-E2 45 kDa subunit
Gene Name Name: NFE2
Organism Homo sapiens (Human)

PRO ID PR:Q16621
DAG View
PRO Name transcription factor NF-E2 45 kDa subunit (human)
Definition A transcription factor NF-E2 45 kDa subunit that is encoded in the genome of human.
Short Label hNFE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16621 (NFE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S107 O-Glycosylation GlyGen   IEDB 28314751
K108 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus 19966288
S157 Phosphorylation P45983 (MAPK8) PhosphoSitePlus 19966288
Y176 Phosphorylation PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
K368 Sumoylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S157 F157 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y180 H180 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K234 R234 Biomuta DOID:1324 / lung cancer [ cosmic ]