iPTMnet Report for Q16620 (NTRK2)
Protein Information
| UniProt AC / UniProt ID | Q16620 / NTRK2_HUMAN |
| Protein Name | BDNF/NT-3 growth factors receptor precursor |
| Gene Name | Name: NTRK2 Synonyms:TRKB; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q16620 |
| PRO Name | BDNF/NT-3 growth factors receptor (human) |
| Definition | A BDNF/NT-3 growth factors receptor that is encoded in the genome of human. |
| Short Label | hNTRK2 |
| Category | organism-gene |
DAG ViewQ16620 (NTRK2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| N61 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| N67 | N-Glycosylation | score4 | GlyGen UniProt | 16335952, 7574684 | ||
| N95 | N-Glycosylation | score4 | GlyGen UniProt | 23090970, 29391424, 7574684, ... | ||
| T97 | O-Glycosylation | score1 | GlyGen | 28657654 | ||
| N121 | N-Glycosylation | score4 | GlyGen UniProt | 16335952, 7574684, 24190977, ... | ||
| S141 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T151 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S153 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T161 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N178 | N-Glycosylation | score4 | GlyGen UniProt | 29391424, 7574684 | ||
| N205 | N-Glycosylation | score3 | GlyGen UniProt | 7574684 | ||
| N241 | N-Glycosylation | score4 | GlyGen UniProt | 23090970, 29671580, 29391424, ... | ||
| T253 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N254 | N-Glycosylation | score4 | GlyGen UniProt | 16335952, 23090970, 29391424, ... | ||
| S256 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S257 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S260 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N280 | N-Glycosylation | score3 | GlyGen UniProt | 7574684 | ||
| N325 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| N338 | N-Glycosylation | score3 | GlyGen UniProt | 7574684 | ||
| N412 | N-Glycosylation | score3 | GlyGen UniProt | 7574684 | ||
| K461 | Acetylation | score1 | PhosphoSitePlus | |||
| S479 | Phosphorylation | score2 | neXtProt | 17341134 | ||
| T506 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y516 | Phosphorylation | score3 | PRO PhosphoSitePlus | 20064930 | ||
| Y516 | Phosphorylation | Q16620 (NTRK2) | score2 | PhosphoSitePlus | 20064930 | |
| Y558 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T573 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S698 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y702 | Phosphorylation | score2 | PRO PhosphoSitePlus | |||
| Y706 | Phosphorylation | score3 | PRO PhosphoSitePlus RLIMS-P | 24116072 | ||
| Y707 | Phosphorylation | score2 | PRO PhosphoSitePlus | |||
| Y817 | Phosphorylation | score4 | PRO PhosphoSitePlus RLIMS-P | 26284337, 28012455 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| N241 | N-Glycosylation | score1 | PRO | 29671580 | ||
| Y516 | Phosphorylation | score1 | HPRD | 10533983 | ||
| Y516 | Phosphorylation | Q16620 (NTRK2) | score1 | HPRD | 10533983 | |
| Y702 | Phosphorylation | score1 | HPRD | 10533983 | ||
| Y702 | Phosphorylation | Q16620 (NTRK2) | score1 | HPRD | 10533983 | |
| Y706 | Phosphorylation | score1 | HPRD | 10533983 | ||
| Y706 | Phosphorylation | Q16620 (NTRK2) | score1 | HPRD | 10533983 | |
| Y707 | Phosphorylation | score1 | HPRD | 10533983 | ||
| Y707 | Phosphorylation | Q16620 (NTRK2) | score1 | HPRD | 10533983 | |
| Y817 | Phosphorylation | score1 | HPRD | 10533983 | ||
| Y817 | Phosphorylation | Q16620 (NTRK2) | score1 | HPRD | 10533983 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y516 | Phosphorylation | score1 | HPRD | 10533983 | ||
| Y516 | Phosphorylation | Q16620 (NTRK2) | score1 | HPRD | 10533983 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y532 | Phosphorylation | score1 | HPRD | 10533983 | ||
| Y532 | Phosphorylation | Q16620 (NTRK2) | score1 | HPRD | 10533983 | |
| Y718 | Phosphorylation | score1 | HPRD | 10533983 | ||
| Y718 | Phosphorylation | Q16620 (NTRK2) | score1 | HPRD | 10533983 | |
| Y722 | Phosphorylation | score1 | HPRD | 10533983 | ||
| Y722 | Phosphorylation | Q16620 (NTRK2) | score1 | HPRD | 10533983 | |
| Y723 | Phosphorylation | score1 | HPRD | 10533983 | ||
| Y723 | Phosphorylation | Q16620 (NTRK2) | score1 | HPRD | 10533983 | |
| Y833 | Phosphorylation | score1 | HPRD | 10533983 | ||
| Y833 | Phosphorylation | Q16620 (NTRK2) | score1 | HPRD | 10533983 |
Q16620 (NTRK2) as PTM Enzyme
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000048646 (hNTRK2/SigPep-/Phos:1) | pY516,pY702,pY706,pY707,pY817 | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T151 | I151 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| N205 | H205 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| N205 | K205 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| T253 | I253 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| N254 | S254 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S257 | F257 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S479 | C479 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| Y516 | * | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| Y532 | * | Biomuta | DOID:363 / uterine cancer [ cosmic, cosmic ] | |
| Y558 | S558 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] |
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