iPTMnet Report for Q16584 (MAP3K11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16584 / M3K11_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 11
Gene Name Name: MAP3K11
Synonyms:MLK3;
Organism Homo sapiens (Human)

PRO ID PR:Q16584
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 11 (human)
Definition A mitogen-activated protein kinase kinase kinase 11 that is encoded in the genome of human.
Short Label hMAP3K11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16584 (MAP3K11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus   UniProt 18691976
S35 Phosphorylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
T277 Phosphorylation Q16584 (MAP3K11) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29084209, 11053428
S281 Phosphorylation Q16584 (MAP3K11) , Q92918 (MAP4K1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11053428, 29084209
S394 Phosphorylation PhosphoSitePlus   UniProt 19369195
T477 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
S507 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...19369195
R512 Methylation PhosphoSitePlus
S524 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 11969422, 23186163, 17192257
T526 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 35843311, ...19369195
S555 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11969422
S556 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11969422
S570 Phosphorylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
S654 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 11969422
S674 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 26152725, 20145118, 12458207
T677 Phosphorylation PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus   UniProt 19369195
T702 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S705 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11969422, 18691976, 29084209, ...19369195
T708 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648
S724 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11969422
S727 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11969422
T738 Phosphorylation PhosphoSitePlus
S740 Phosphorylation IEDB   PhosphoSitePlus   UniProt 11969422, 27869121
S746 Phosphorylation PhosphoSitePlus
S748 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
T752 Phosphorylation PhosphoSitePlus
T755 Phosphorylation IEDB   PhosphoSitePlus 27869121
S758 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 19369195, 11969422, ...32157095, 29084209, 27869121
S770 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11969422, 35843311
S774 Phosphorylation PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus
S789 Phosphorylation P49840 (GSK3A) phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 17711861, ...19690332
S793 Phosphorylation P49840 (GSK3A) phospho.ELM   PhosphoSitePlus   UniProt 18691976, 19369195, 11969422, ...18669648, 17711861, 19690332
S815 Phosphorylation PhosphoSitePlus   UniProt 18691976
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 18691976
S19 Phosphorylation HPRD 18691976
S35 Phosphorylation HPRD 18691976
T277 Phosphorylation Q16584 (MAP3K11) HPRD 11053428
S281 Phosphorylation Q92918 (MAP4K1) HPRD 11053428
S493 Phosphorylation HPRD 18691976
S507 Phosphorylation HPRD 18691976, 16964243
S524 Phosphorylation HPRD 11969422, 18691976
S548 Phosphorylation HPRD 18691976
S555 Phosphorylation HPRD 11969422
S556 Phosphorylation HPRD 11969422
S569 Phosphorylation HPRD 18691976
S654 Phosphorylation HPRD 11969422
S674 Phosphorylation P31749 (AKT1) HPRD 12458207
T702 Phosphorylation HPRD 18691976, 18669648
S705 Phosphorylation HPRD 11969422, 18691976
T708 Phosphorylation HPRD 18691976, 18669648
S724 Phosphorylation HPRD 11969422
S727 Phosphorylation HPRD 11969422
T738 Phosphorylation HPRD 18691976, 17924679
S740 Phosphorylation HPRD 11969422, 18691976, 17924679
S746 Phosphorylation HPRD 17924679
S748 Phosphorylation HPRD 18691976
T752 Phosphorylation HPRD 18691976
T755 Phosphorylation HPRD 18691976
S758 Phosphorylation HPRD 11969422, 18691976
S765 Phosphorylation HPRD 18691976
S770 Phosphorylation HPRD 11969422
S789 Phosphorylation HPRD 18669648
S793 Phosphorylation HPRD 11969422, 18691976, 18669648
S815 Phosphorylation HPRD 18691976


Q16584 (MAP3K11) as PTM Enzyme



Substrate Site Score Source PMID
P45985 (MAP2K4) S257 neXtProt   PhosphoSitePlus   Signor 9003778, 15328343
P45985 (MAP2K4) T261 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11053428, 9003778, 10727406
P46734 (MAP2K3) S218 PhosphoSitePlus 9003778
P46734 (MAP2K3) T222 PhosphoSitePlus 9003778
Q13131 (PRKAA1) T183 PhosphoSitePlus 25874865
Q13526 (PIN1) S138 PhosphoSitePlus   Signor 25519816, 22566623
Q16584 (MAP3K11) T277 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11053428
Q16584 (MAP3K11) S281 phospho.ELM   PhosphoSitePlus   Signor   UniProt 11053428


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35240 (NF2) S518 Q16584 (MAP3K11) inhibited_association eFIP 20890305
Phosphorylation Q16584 (MAP3K11) S705 P15056 (BRAF) unknown eFIP 29084209


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 N11 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S19 N19 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S19 G19 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R512 W512 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S548 F548 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S570 F570 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S654 L654 Biomuta DOID:4159 / skin cancer [ cosmic ]
T702 M702 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S770 L770 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]