iPTMnet Report for Q16566 (CAMK4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16566 / KCC4_HUMAN
Protein Name Calcium/calmodulin-dependent protein kinase type IV
Gene Name Name: CAMK4
Synonyms:CAMK,CAMK-GR,CAMKIV;
Organism Homo sapiens (Human)

PRO ID PR:Q16566
DAG View
PRO Name calcium/calmodulin-dependent protein kinase type IV (human)
Definition A calcium/calmodulin-dependent protein kinase type IV that is encoded in the genome of human.
Short Label hCAMK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16566 (CAMK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation Q8N5S9 (CAMKK1) , Q16566 (CAMK4) PRO   PhosphoSitePlus   UniProt 8702940
S13 Phosphorylation Q16566 (CAMK4) , Q8N5S9 (CAMKK1) PRO   PhosphoSitePlus   UniProt 8702940
Y32 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
T57 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 34725712, 26853435, 19506079, ...27935279, 22311971, 22564745, 30296064, 33709700
S58 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 34725712, 26853435, 19506079, ...27935279, 22311971, 22564745, 30296064, 33709700
K66 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
S137 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 34725712, 26853435, 19506079, ...27935279, 22311971, 22564745, 30296064, 33709700
K166 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
S189 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 34725712, 26853435, 19506079, ...27935279, 22311971, 22564745, 30296064, 33709700
S189 Phosphorylation PhosphoSitePlus
K190 Acetylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
T200 Phosphorylation Q8N5S9 (CAMKK1) , Q96RR4 (CAMKK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8702940, 8621423, 21957496, ...9163534, 19506079, 9822657, 15769749, 7615569, 10833263, 15143065, 19538941
T204 Phosphorylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
S341 Phosphorylation Q16566 (CAMK4) HPRD   phospho.ELM   PhosphoSitePlus 17192257
S343 Phosphorylation PhosphoSitePlus
S344 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 34725712, 26853435, 19506079, ...27935279, 22311971, 22564745, 30296064, 33709700
S344 Phosphorylation PhosphoSitePlus
S345 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 34725712, 26853435, 19506079, ...27935279, 22311971, 22564745, 30296064, 33709700
S345 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
S356 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 34725712, 26853435, 19506079, ...27935279, 22311971, 22564745, 30296064, 33709700
S356 Phosphorylation HPRD   PhosphoSitePlus 19413330
S360 Phosphorylation Q16566 (CAMK4) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 19690332, 17192257
K404 Ubiquitination PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus


Q16566 (CAMK4) as PTM Enzyme



Substrate Site Score Source PMID
P14866 (HNRNPL) S544 PhosphoSitePlus   Signor 22570490
P16220 (CREB1) S119 Signor 17389598, 12835716
P16949 (STMN1) S16 neXtProt   PhosphoSitePlus   Signor 7925472, 9154845
P29475-1 (NOS1) S852 HPRD 10874031, 12630910, 1375933, ...10400690
P53667 (LIMK1) T508 neXtProt 19696021
P56524-1 (HDAC4) S467 HPRD 11470791, 18669648
P56524-1 (HDAC4) S632 HPRD 11470791, 19651622, 18669648, ...20068231
Q04206 (RELA) S536 PhosphoSitePlus 12767944
Q16566 (CAMK4) S12 UniProt 8702940
Q16566 (CAMK4) S13 UniProt 8702940
Q16566 (CAMK4) S341 HPRD 17192257
Q16566 (CAMK4) S360 HPRD 19413330, 17192257
Q92793-1 (CREBBP) S302 HPRD 11970865
Q99623 (PHB2) S91 PhosphoSitePlus   Signor 21689744
Q9UNW9 (NOVA2) S25 Signor 32492405
Q9UNW9 (NOVA2) T27 Signor 32492405
Q9UNW9 (NOVA2) S194 Signor 32492405
Q9UQL6 (HDAC5) S259 PhosphoSitePlus   Signor 11114197, 11081517, 12058061
Q9UQL6 (HDAC5) S498 PhosphoSitePlus   Signor 11114197, 11081517, 12058061
Q9UQM7-2 (CAMK2A) S332 PhosphoSitePlus 9677407


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046559 (hCAMK4/Phos:2) pS12,pS13 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q16566 (CAMK4) T200 Q15257 (PTPA) unknown eFIP 15143065


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y32 F32 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S58 F58 Biomuta DOID:4159 / skin cancer [ cosmic ]
K199 R199 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S344 R344 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S348 N348 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K354 R354 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S360 A360 Biomuta DOID:4159 / skin cancer [ cosmic ]
K404 N404 Biomuta [ cosmic ]