iPTMnet Report for Q16555 (DPYSL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16555 / DPYL2_HUMAN
Protein Name Dihydropyrimidinase-related protein 2
Gene Name Name: DPYSL2
Synonyms:CRMP2,ULIP2;
Organism Homo sapiens (Human)

PRO ID PR:Q16555
DAG View
PRO Name dihydropyrimidinase-related protein 2 (human)
Definition A dihydropyrimidinase-related protein 2 that is encoded in the genome of human.
Short Label hDPYSL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16555 (DPYSL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S2 Phosphorylation PhosphoSitePlus
T13 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 19652227, 29396402
Y32 Phosphorylation P06241 (FYN) neXtProt 19652227
T57 Phosphorylation PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
T241 O-Glycosylation GlyGen 33214551, 30397120, 28657654, ...34725712, 34019948, 31637018, 31373491, 35132862, 34931806, 28510447, 34229054
K254 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
T280 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
K345 Acetylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
T358 Phosphorylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K374 Sumoylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
T424 Phosphorylation PhosphoSitePlus
Y431 Phosphorylation PhosphoSitePlus
C439 S-Nitrosylation dbSNO 26338901
K472 Ubiquitination PhosphoSitePlus
Y479 Phosphorylation PhosphoSitePlus   RLIMS-P 19276087, 29396402
Y479 Phosphorylation P07947 (YES1) PhosphoSitePlus 19276087
R492 Methylation PhosphoSitePlus
Y499 Phosphorylation PhosphoSitePlus   RLIMS-P 29396402
C504 Methylation IEDB 31844290
C504 S-Nitrosylation dbSNO 19483679, 26338901
S507 O-Glycosylation GlyGen 33214551, 30397120, 28657654, ...34725712, 34019948, 31637018, 31373491, 35132862, 34931806, 28510447, 34229054
S507 Phosphorylation PhosphoSitePlus
T509 O-Glycosylation GlyGen 33214551, 30397120, 28657654, ...34725712, 34019948, 31637018, 31373491, 35132862, 34931806, 28510447, 34229054
T509 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27609071, 21406692, 32094324, ...23186163, 16964243, 15466863, 10757975, 18669648, 24904280, 20831597, 25040932, 25104922
T509 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 25040932, 15466863
K511 Ubiquitination PhosphoSitePlus
T512 O-Glycosylation GlyGen 33214551, 30397120, 28657654, ...34725712, 34019948, 31637018, 31373491, 35132862, 34931806, 28510447, 34229054
T512 Phosphorylation PhosphoSitePlus
T514 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 15466863, 31024297, 20831597, ...25040932, 30816227, 21406692, 32094324, 15483118, 34975828, 27609071, 25995380, 31561361, 33401710, 24904280, 32778769, 16190365, 23023514, 18669648, 29926835, 26952865, 15652488
T514 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P+   Signor 25040932, 15652488, 15466863, ...15483118
S517 O-Glycosylation GlyGen 33214551, 30397120, 28657654, ...34725712, 34019948, 31637018, 31373491, 35132862, 34931806, 28808029, 28510447, 34229054
S517 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S518 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 27609071, 21406692, 32094324, ...17902168, 15466863, 15483118, 10757975
S518 Phosphorylation P49840 (GSK3A) PhosphoSitePlus 17902168
S518 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P+ 15483118, 17902168, 15466863
K520 Acetylation PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
T521 Phosphorylation PhosphoSitePlus
S522 Phosphorylation IEDB   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 27609071, 32778769, 21406692, ...32094324, 16964243, 17902168, 15466863, 15676027, 26389656, 28855257, 10757975, 16611631, 33401710, 18669648, 15483118, 29926835, 25040932, 15652488, 26555036, 25104922
S522 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P+   Signor 25040932, 16611631, 17902168, ...26555036, 15483118
S522 Phosphorylation Q92630 (DYRK2) neXtProt   PhosphoSitePlus 15466863, 16611631
K525 Acetylation PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
S537 O-Glycosylation GlyGen 33214551, 30397120, 28657654, ...34725712, 34019948, 31637018, 31373491, 35132862, 34931806, 28510447, 34229054
S537 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
T554 Phosphorylation PhosphoSitePlus
T555 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 33401710, 29066950, 10818093, ...22443207, 29926835, 25147500, 16595691
T555 Phosphorylation O75116 (ROCK2) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10818093
T555 Phosphorylation Q13464 (ROCK1) PhosphoSitePlus 22443207, 10818093
R565 Methylation PhosphoSitePlus
T569 Phosphorylation PhosphoSitePlus
S570 O-Glycosylation GlyGen 33214551, 30397120, 28657654, ...34725712, 34019948, 31637018, 31373491, 35132862, 34931806, 28510447, 34229054
S570 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T509 Phosphorylation HPRD 19413330, 16964243, 18767875, ...19664994, 19664995, 17322306, 18669648, 19415658, 20068231, 18212344
T512 Phosphorylation HPRD 19413330, 20068231
T514 Phosphorylation HPRD 19413330, 18491316, 16964243, ...19651622, 18669648, 15652488
T514 Phosphorylation P49841 (GSK3B) HPRD 19413330, 18491316, 16964243, ...19651622, 18669648, 15652488
S517 Phosphorylation HPRD 19651622, 18669648
S518 Phosphorylation HPRD 19413330, 19651622, 19664995, ...20068231
T521 Phosphorylation HPRD 19413330, 19651622, 18491316
S522 Phosphorylation HPRD 19413330, 19651622, 18669648, ...16964243, 19664995
S537 Phosphorylation HPRD 20166139, 20068231
S542 Phosphorylation HPRD 20068231
T555 Phosphorylation HPRD 10818093
T555 Phosphorylation Q13464 (ROCK1) HPRD 10818093


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047204 (hDPYSL2/Phos:2) pS522 PRO
PR:000047205 (hDPYSL2/Phos:3) pT509,pT514,pS518,pS522 PRO
PR:000047206 (hDPYSL2/PhosTyr+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T57 I57 Biomuta DOID:4159 / skin cancer [ cosmic ]
K293 N293 Biomuta DOID:1324 / lung cancer [ cosmic ]
R492 K492 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T509 M509 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T521 M521 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S537 P537 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R565 H565 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]