Protein Information

Cytoscape View

UniProt AC / UniProt ID Q16543 / CDC37_HUMAN
Protein Name Hsp90 co-chaperone Cdc37
Gene Name Name: CDC37
Organism Homo sapiens (Human)

PRO ID PR:Q16543
DAG View
PRO Name Hsp90 co-chaperone Cdc37 (human)
Definition An Hsp90 co-chaperone Cdc37 that is encoded in the genome of human.
Short Label hCDC37
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q16543 (CDC37) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
V2 Acetylation UniProt 19413330, 21406692, 20068231
Y4 Phosphorylation PhosphoSitePlus   RLIMS-P 29343704
S5 Phosphorylation PhosphoSitePlus
S13 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 21406692, 18566753, ...12930845, 32800562, 17922836, 29478821, 15082798, 24292678, 31776458, 21871133, 25619116, 18922470, 27015562, 25788269, 31226489, 27251758, 20068231
K45 Acetylation PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K78 Acetylation PhosphoSitePlus   UniProt 19608861
K93 Ubiquitination PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus   UniProt 23186163
S120 Phosphorylation PhosphoSitePlus   UniProt 23186163
K121 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
K132 Sumoylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus   UniProt 19608861
K157 Acetylation PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
R246 Methylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
Y298 Phosphorylation P07947 (YES1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 15592455, 22727666, 29343704
S300 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
C308 S-Nitrosylation dbSNO 19483679
K312 Ubiquitination PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K330 Acetylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
C336 S-Nitrosylation dbSNO 19483679
S339 Phosphorylation PhosphoSitePlus   RLIMS-P 28073914
S346 Phosphorylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
T370 Phosphorylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
S377 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P07900 (HSP90AA1) Y197 Q16543 (CDC37) unknown eFIP 29343704
Phosphorylation Q16543 (CDC37) S13 P07900 (HSP90AA1) unknown eFIP 21871133
Phosphorylation Q16543 (CDC37) S13 P07900 (HSP90AA1) unknown eFIP 17922836
Phosphorylation Q16543 (CDC37) S13 P07900 (HSP90AA1) unknown eFIP 12930845
Phosphorylation Q16543 (CDC37) S13 P07900 (HSP90AA1) unknown eFIP 25619116

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 V1 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S5 G5 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K69 N69 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K110 N110 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T118 M118 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S120 G120 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T136 M136 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R246 C246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R246 L246 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
T370 M370 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]