iPTMnet Report for Q16539 (MAPK14)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16539 / MK14_HUMAN
Protein Name Mitogen-activated protein kinase 14
Gene Name Name: MAPK14
Synonyms:CSBP,CSBP1,CSBP2,CSPB1,MXI2,SAPK2A;
Organism Homo sapiens (Human)

PRO ID PR:Q16539
DAG View
PRO Name mitogen-activated protein kinase 14 (human)
Definition A mitogen-activated protein kinase 14 that is encoded in the genome of human.
Short Label hMAPK14
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16539 (MAPK14) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 20068231
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T7 Phosphorylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
T16 Phosphorylation PhosphoSitePlus   UniProt 18691976
S28 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
R49 Methylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus   UniProt 21444723
K54 Ubiquitination PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
R70 Methylation PhosphoSitePlus
K79 Sumoylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
T123 Phosphorylation neXtProt   PhosphoSitePlus   Signor 17055984
T123 Phosphorylation P25098 (GRK2) neXtProt   PhosphoSitePlus   Signor 17055984
K139 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
R149 Methylation PhosphoSitePlus
K152 Acetylation PhosphoSitePlus   UniProt 21444723
K152 Sumoylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
T180 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21452291, 15972258, 21351482, ...27698876, 25151490, 19920149, 31107893, 15642743, 7839144, 26661061, 10781613, 17126298, 19324872, 17126905, 26279444, 19749799, 19564926, 28117030, 26818586, 17548358, 24590766, 26300649, 29463565, 17192257, 27303303, 27863490, 25504435, 22404972, 15674326, 23717592, 31057551, 23157661, 23532963, 23805842, 23744074, 8622669, 26373535, 14651992, 33477536, 30250582, 21146537, 27067799, 30133342, 29807370, 23186163, 20957493, 31160572, 15735648, 33663544, 19690332, 30013476, 7535770, 11823524, 11971971, 26239883, 27270236, 28467493, 16083285, 11180173, 22347375, 18669648, 21072193, 29229647, 18625049, 33522434, 25834400, 33628174, 28469980, 30463908, 29716528, 29167821, 18669639, 19209848, 29955707, 23560844, 27543462, 21283629, 21241662, 16203857, 31856414, 20068231, 7750576, 23765260, 20109185, 31969827, 17210579
T180 Phosphorylation O95382 (MAP3K6) PhosphoSitePlus 17210579
T180 Phosphorylation P07949 (RET) Signor 17548358, 8622669, 7535770, ...17126298
T180 Phosphorylation P45985 (MAP2K4) neXtProt   PhosphoSitePlus   Signor 7839144, 7535770
T180 Phosphorylation P46734 (MAP2K3) neXtProt   PhosphoSitePlus   Signor 11971971, 7839144, 19920149, ...8622669
T180 Phosphorylation P52564 (MAP2K6) neXtProt   phospho.ELM   PhosphoSitePlus 15972258, 17548358, 8622669, ...24590766, 11971971, 19920149
T180 Phosphorylation Q16539 (MAPK14) neXtProt   UniProt 15735648, 18669648
T180 Phosphorylation Q99683 (MAP3K5) PhosphoSitePlus 19749799
Y182 Phosphorylation IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21452291, 15972258, 21351482, ...27698876, 15659558, 19920149, 31107893, 15642743, 7839144, 26661061, 10781613, 17126298, 17126905, 26279444, 15592455, 19749799, 19564926, 28117030, 29716528, 17081983, 26818586, 17548358, 24590766, 26300649, 29463565, 17192257, 23771849, 27863490, 25504435, 22404972, 15674326, 23717592, 31057551, 23157661, 23532963, 23805842, 23744074, 8622669, 25741596, 26373535, 14651992, 26459859, 33477536, 30250582, 33188182, 27067799, 24309931, 30133342, 25151490, 29807370, 23186163, 20957493, 25605239, 31160572, 15735649, 15735648, 33663544, 11062067, 19690332, 30013476, 7535770, 11823524, 11971971, 26239883, 20830230, 27270236, 28467493, 16083285, 27303303, 11180173, 22347375, 18669648, 16153436, 29229647, 18625049, 33522434, 25834400, 21982020, 33628174, 28469980, 30463908, 26438733, 29167821, 18669639, 18088087, 29955707, 23560844, 27543462, 21283629, 21241662, 16203857, 31856414, 18083107, 20068231, 23765260, 20109185, 31969827, 17210579
Y182 Phosphorylation O14733-2 (MAP2K7) neXtProt 11062067
Y182 Phosphorylation O95382 (MAP3K6) PhosphoSitePlus 17210579
Y182 Phosphorylation P07949 (RET) neXtProt   PhosphoSitePlus   Signor 17548358, 8622669, 16153436, ...17126298, 7535770
Y182 Phosphorylation P45985 (MAP2K4) neXtProt   PhosphoSitePlus 7839144
Y182 Phosphorylation P46734 (MAP2K3) neXtProt   PhosphoSitePlus   Signor 11971971, 7839144, 19920149, ...8622669
Y182 Phosphorylation P52564 (MAP2K6) neXtProt   PhosphoSitePlus 11971971, 17548358, 8622669, ...19920149, 24590766
Y182 Phosphorylation Q16539 (MAPK14) neXtProt   UniProt 15735648, 18669648
Y182 Phosphorylation Q99683 (MAP3K5) PhosphoSitePlus 19749799
T185 Phosphorylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
R256 Methylation PhosphoSitePlus
T263 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K295 Ubiquitination PhosphoSitePlus
Y323 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24863062, 21452291, 21146537, ...19324872, 15735648, 16103752, 33663544, 25151490
Y323 Phosphorylation P06239 (LCK) neXtProt   PhosphoSitePlus 15735648
Y323 Phosphorylation P06241 (FYN) neXtProt   PhosphoSitePlus   Signor 15735648
Y323 Phosphorylation P43403 (ZAP70) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15735648
S326 Phosphorylation PhosphoSitePlus   RLIMS-P 27354066
K338 Sumoylation PhosphoSitePlus
S339 Phosphorylation RLIMS-P 27245949
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 18691976, 20068231
Y9 Phosphorylation HPRD 18691976
T16 Phosphorylation HPRD 18691976
T175 Phosphorylation HPRD 18669648, 20068231
T180 Phosphorylation HPRD   PRO 18691976, 15642743, 18767875, ...19651622, 17322306, 18669648, 20068231
Y182 Phosphorylation HPRD   PRO 17016520, 18691976, 18088087, ...15642743, 18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976
Y182 Phosphorylation P07949 (RET) HPRD 17016520, 18691976, 18088087, ...18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976
Y182 Phosphorylation P52564 (MAP2K6) HPRD 17016520, 18691976, 18088087, ...18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976
T263 Phosphorylation HPRD 17525332
T298 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 18691976, 20068231
Y9 Phosphorylation HPRD 18691976
T16 Phosphorylation HPRD 18691976
T175 Phosphorylation HPRD 18669648, 20068231
T180 Phosphorylation HPRD 18691976, 18767875, 19651622, ...17322306, 18669648, 20068231
T180 Phosphorylation P46734 (MAP2K3) HPRD 18691976, 18767875, 19651622, ...17322306, 18669648, 20068231
T180 Phosphorylation P52564 (MAP2K6) HPRD 18691976, 18767875, 19651622, ...17322306, 18669648, 20068231
Y182 Phosphorylation HPRD   PhosphoSitePlus 17016520, 18691976, 18088087, ...18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976
Y182 Phosphorylation P07949 (RET) HPRD 17016520, 18691976, 18088087, ...18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976
Y182 Phosphorylation P52564 (MAP2K6) HPRD 17016520, 18691976, 18088087, ...18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976
T241 Phosphorylation HPRD   PhosphoSitePlus 18691976
R249 Methylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
T263 Phosphorylation HPRD 17525332, 20068231
T298 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 18691976, 20068231
Y9 Phosphorylation HPRD 18691976
T16 Phosphorylation HPRD 18691976
T175 Phosphorylation HPRD 18669648, 20068231
T180 Phosphorylation HPRD 18691976, 18767875, 19651622, ...17322306, 18669648, 20068231
Y182 Phosphorylation HPRD 17016520, 18691976, 18088087, ...18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976
Y182 Phosphorylation P07949 (RET) HPRD 17016520, 18691976, 18088087, ...18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976
Y182 Phosphorylation P52564 (MAP2K6) HPRD 17016520, 18691976, 18088087, ...18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976
T263 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 18691976, 20068231
Y9 Phosphorylation HPRD 18691976
T16 Phosphorylation HPRD 18691976
T175 Phosphorylation HPRD 18669648, 20068231
T180 Phosphorylation HPRD 18691976, 18767875, 19651622, ...17322306, 18669648, 20068231
Y182 Phosphorylation HPRD 17016520, 18691976, 18088087, ...18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976
Y182 Phosphorylation P07949 (RET) HPRD 17016520, 18691976, 18088087, ...18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976
Y182 Phosphorylation P52564 (MAP2K6) HPRD 17016520, 18691976, 18088087, ...18452278, 19651622, 18669648, 16153436, 19901323, 20068231, 16497976


Q16539 (MAPK14) as PTM Enzyme



Substrate Site Score Source PMID
F1D8S2 (NR2A1) S167 HPRD 16351573
O00418 (EEF2K) S396 HPRD   neXtProt 12171600
O15198 (SMAD9) T136 PhosphoSitePlus 22394512
O43255 (SIAH2) S28 neXtProt 17003045
O43257 (ZNHIT1) T103 HPRD   neXtProt   PhosphoSitePlus   Signor 17380123
O43521 (BCL2L11) S69 neXtProt 16818494
O43524 (FOXO3) S7 neXtProt   PhosphoSitePlus   Signor 22128155
O43524 (FOXO3) S12 neXtProt   PhosphoSitePlus 22128155
O43524 (FOXO3) S294 neXtProt   PhosphoSitePlus 22128155
O43524 (FOXO3) S344 neXtProt   PhosphoSitePlus 22128155
O43524 (FOXO3) S425 neXtProt   PhosphoSitePlus 22128155
O60381 (HBP1) S402 neXtProt   PhosphoSitePlus   Signor 14612426
O75030 (MITF) S414 neXtProt 11792706
O75582 (RPS6KA5) S360 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17117922, 15568999
O75582-1 (RPS6KA5) S376 HPRD 19651622, 11994045, 20068231
O75582 (RPS6KA5) T581 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11994045, 17117922, 14578350, ...15568999, 17429437
O75582 (RPS6KA5) T700 neXtProt 17117922
O75676-2 (RPS6KA4) S196 HPRD   phospho.ELM   PhosphoSitePlus   Signor 10806207, 17429437
O75676-2 (RPS6KA4) S343 HPRD   phospho.ELM   Signor 10806207, 18691976, 19651622, ...20068231
O75676-2 (RPS6KA4) S347 HPRD   phospho.ELM   Signor 10806207, 18691976, 19651622, ...16964243, 20068231
O75676-2 (RPS6KA4) S360 HPRD   phospho.ELM   Signor 10806207
O75676-2 (RPS6KA4) T562 HPRD 10806207
O75676 (RPS6KA4) T568 HPRD   phospho.ELM   Signor 10806207
O75928 (PIAS2) S113 Signor 16713578
O75928 (PIAS2) S116 Signor 16713578
O95644 (NFATC1) S172 neXtProt   PhosphoSitePlus   Signor 10652349, 24863062
P00533 (EGFR) T693 neXtProt   PhosphoSitePlus 16785992
P00533 (EGFR) S1039 PhosphoSitePlus 19531499
P00533 (EGFR) T1041 PhosphoSitePlus 19531499
P02511 (CRYAB) S59 PhosphoSitePlus 20005263
P03372 (ESR1) S118 neXtProt   PhosphoSitePlus   Signor 15879307
P03372 (ESR1) S294 PhosphoSitePlus 22431515
P03372-1 (ESR1) T311 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12138194, 16741565
P04150 (NR3C1) S203 PhosphoSitePlus 24024586
P04150 (NR3C1) S211 neXtProt   PhosphoSitePlus   Signor 15817653, 19841061
P04150 (NR3C1) S226 PhosphoSitePlus 19812390, 22911818
P04637 (TP53) S15 neXtProt   PhosphoSitePlus   Signor 11258706, 10781582, 10581258, ...12091386
P04637 (TP53) S33 neXtProt   PhosphoSitePlus   Signor 11258706, 10581258, 17535811, ...11101524, 22975381, 11495913
P04637 (TP53) S46 neXtProt   PhosphoSitePlus   Signor 15642743, 10581258, 17535811
P04637-1 (TP53) S392 HPRD 19413330, 10747897, 10348343, ...10884347
P04792 (HSPB1) S176 PhosphoSitePlus 22394512
P05198 (EIF2S1) S52 neXtProt   PhosphoSitePlus 17404396
P05787-1 (KRT8) S74 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9211903, 18691976, 19007248, ...11781324, 11788583, 20724476
P06400 (RB1) S567 neXtProt   PhosphoSitePlus   Signor 20871633
P06702 (S100A9) T113 neXtProt   PhosphoSitePlus 15905572
P10275 (AR) S651 PhosphoSitePlus 16282370
P10415 (BCL2) T56 PhosphoSitePlus   Signor 19336399, 16714293
P10415 (BCL2) S87 PhosphoSitePlus   Signor 19336399, 16714293
P10636-8 (MAPT) T50 neXtProt 15632108
P10636-8 (MAPT) T69 neXtProt 15632108
P10636-8 (MAPT) T153 neXtProt 15632108
P10636-8 (MAPT) S202 neXtProt 15632108
P10636-8 (MAPT) T205 neXtProt 15632108
P10636-8 (MAPT) S235 neXtProt 15632108
P10636-8 (MAPT) S404 neXtProt 15632108
P10636-8 (MAPT) S422 neXtProt 15632108
P11362 (FGFR1) S777 neXtProt   PhosphoSitePlus   Signor 20626350, 18411303, 23405013
P13726 (F3) S285 PhosphoSitePlus 23195225
P13726 (F3) S290 PhosphoSitePlus   Signor 23195225
P14598 (NCF1) S345 neXtProt   phospho.ELM   PhosphoSitePlus 15629715, 16778989
P14598 (NCF1) S348 neXtProt   phospho.ELM   PhosphoSitePlus 15629715
P15336-1 (ATF2) T69 HPRD   neXtProt   PhosphoSitePlus   Signor 19413330, 15304344, 18767875, ...10777545, 7535770, 19651622, 11259436, 18669648, 10085140, 12110590, 20068231
P15336-1 (ATF2) T71 HPRD   neXtProt   PhosphoSitePlus   Signor 19413330, 15304344, 18767875, ...10777545, 7535770, 19651622, 11259436, 18669648, 17671211, 10085140, 19920149, 12110590, 20068231, 11896587
P15336 (ATF2) S90 HPRD   Signor 19413330, 10085140, 11259586
P15923 (TCF3) S139 neXtProt   Signor 15719023
P16949 (STMN1) S25 neXtProt 16110469
P17181 (IFNAR1) S532 PhosphoSitePlus 21666722, 21695243
P17275 (JUNB) S79 phospho.ELM   Signor 15308641
P17275 (JUNB) T102 HPRD 18669648, 9889198, 20068231, ...8917518
P17275 (JUNB) T104 HPRD 18669648, 9889198, 20068231, ...8917518
P17302 (GJA1) S279 PhosphoSitePlus 18047584
P17302 (GJA1) S282 PhosphoSitePlus 18047584
P17844 (DDX5) T446 PhosphoSitePlus 23110695
P17844 (DDX5) T564 PhosphoSitePlus 23110695
P17861 (XBP1) S68 neXtProt 21892182
P18850 (ATF6) T166 PhosphoSitePlus 25135476
P19419 (ELK1) S383 HPRD   phospho.ELM   PhosphoSitePlus   Signor 8548291, 20727996, 9130707, ...8887554, 11145955
P19419 (ELK1) S389 HPRD   phospho.ELM   Signor 8548291, 9130707
P19525 (EIF2AK2) T451 neXtProt   PhosphoSitePlus 17404396
P19634 (SLC9A1) T718 HPRD   phospho.ELM   PhosphoSitePlus   Signor 11604491
P19634 (SLC9A1) S723 HPRD   phospho.ELM   PhosphoSitePlus   Signor 11604491, 18669648, 20068231
P19634 (SLC9A1) S726 HPRD   phospho.ELM   PhosphoSitePlus   Signor 20068231, 11604491, 18669648, ...18701649
P19634-1 (SLC9A1) S729 HPRD   phospho.ELM   PhosphoSitePlus   Signor 18701649, 11604491, 18669648, ...20068231
P21397 (MAOA) S209 PhosphoSitePlus 19650872
P21462 (FPR1) S342 neXtProt   PhosphoSitePlus 22447027
P22415 (USF1) T153 neXtProt   PhosphoSitePlus   Signor 19389701, 11532965
P28324 (ELK4) S381 neXtProt 9130707
P28324 (ELK4) S387 neXtProt 9130707
P28698 (MZF1) S256 neXtProt 12427756
P28698 (MZF1) S274 neXtProt 12427756
P28698 (MZF1) S294 neXtProt 12427756
P29353 (SHC1) S36 neXtProt 11602589
P29353 (SHC1) S54 PhosphoSitePlus 16251354
P29353 (SHC1) T56 neXtProt 16251354
P29353 (SHC1) T386 neXtProt   PhosphoSitePlus 16251354
P30279 (CCND2) T280 neXtProt   PhosphoSitePlus 17486076
P30305 (CDC25B) S323 neXtProt 11333986
P30305 (CDC25B) S375 neXtProt 11333986
P30307 (CDC25C) S216 HPRD   neXtProt 9543386, 10557092, 9278512, ...11333986, 11551930, 20068231
P31645 (SLC6A4) T616 PhosphoSitePlus 24450286
P35236 (PTPN7) T66 neXtProt   PhosphoSitePlus 10206983
P35236 (PTPN7) S93 neXtProt   PhosphoSitePlus 10206983
P35236-2 (PTPN7) T105 HPRD 18088087, 10206983
P35236-2 (PTPN7) S132 HPRD 10206983
P35638 (DDIT3) S79 HPRD   PhosphoSitePlus   Signor 8650547
P35638 (DDIT3) S82 HPRD   PhosphoSitePlus 8650547
P36956-3 (SREBF1) S39 PhosphoSitePlus 25353341
P36956 (SREBF1) S63 PhosphoSitePlus 22384276
P36956-3 (SREBF1) T402 PhosphoSitePlus 25353341
P36956 (SREBF1) T426 PhosphoSitePlus 22384276
P38936 (CDKN1A) T57 neXtProt   PhosphoSitePlus 12058028
P38936 (CDKN1A) S130 neXtProt   PhosphoSitePlus   Signor 12058028
P40763 (STAT3) S727 PhosphoSitePlus   Signor 18691976, 12748293, 17502367
P41212 (ETV6) S22 PhosphoSitePlus 12435397
P41212 (ETV6) S257 PhosphoSitePlus 18022807, 12435397
P41235-5 (HNF4A) S145 HPRD 16351573
P41235 (HNF4A) S167 HPRD   neXtProt   PhosphoSitePlus 17317687, 16351573
P41970 (ELK3) S357 Signor 9130707
P41970 (ELK3) S363 HPRD   Signor 9130707, 11042694
P42224 (STAT1) S727 neXtProt   PhosphoSitePlus   Signor 17897103, 14963018, 12748293, ...17502367
P42566 (EPS15) S796 PhosphoSitePlus   Signor 24269888
P42574 (CASP3) S150 phospho.ELM   PhosphoSitePlus   Signor 14970175
P42677 (RPS27) S27 PhosphoSitePlus 22394512
P47712 (PLA2G4A) S505 HPRD   Signor 10978317, 8910365, 20068231, ...8636128
P49023 (PXN) S85 neXtProt   PhosphoSitePlus   Signor 14970194
P49137 (MAPKAPK2) T25 HPRD   phospho.ELM   PhosphoSitePlus   Signor 8846784
P49137-1 (MAPKAPK2) T206 HPRD 7592979
P49137 (MAPKAPK2) T222 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14499342, 18669648, 7592979, ...8846784
P49137 (MAPKAPK2) S272 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14499342, 8846784
P49137-2 (MAPKAPK2) T317 HPRD 7592979
P49137-2 (MAPKAPK2) T334 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14499342, 8846784, 7592979
P49841 (GSK3B) S389 PhosphoSitePlus   Signor 22039048, 17726008, 18451303
P49841 (GSK3B) T390 PhosphoSitePlus 18451303
P49918 (CDKN1C) S146 neXtProt 22569127
P52945 (PDX1) S61 neXtProt   PhosphoSitePlus 12810726
P52945 (PDX1) S66 neXtProt   PhosphoSitePlus 12810726
P53667 (LIMK1) S310 neXtProt   PhosphoSitePlus 16456544
P56178 (DLX5) S34 neXtProt 18056716
P56178 (DLX5) S217 neXtProt 18056716
P61244-2 (MAX) S40 HPRD 7479834
P61244-6 (MAX) S49 HPRD 7479834
P61244-2 (MAX) S135 HPRD 11535131, 19651622, 18452278
P61244-1 (MAX) S144 HPRD 11535131, 19651622, 18452278
P68431 (H3C12) S11 Signor 20626350
P68431 (H3C12) S29 neXtProt 11278789
P78356 (PIP4K2B) S326 neXtProt   PhosphoSitePlus   Signor 16949365
P78536 (ADAM17) T735 neXtProt   PhosphoSitePlus 20188673
P78543 (BTG2) S149 neXtProt 15788397
P84022 (SMAD3) S204 Signor 15520018
P84022-1 (SMAD3) S208 HPRD   Signor 15520018, 14512875
P84022-1 (SMAD3) S213 HPRD 14512875
Q01844 (EWSR1) T79 PhosphoSitePlus   Signor 19076070
Q02078 (MEF2A) S98 PhosphoSitePlus 12586839
Q02078 (MEF2A) T108 PhosphoSitePlus 12586839
Q02078 (MEF2A) S192 PhosphoSitePlus 12586839
Q02078 (MEF2A) S223 PhosphoSitePlus 12586839
Q02078-5 (MEF2A) T304 HPRD 10849446, 9858528
Q02078-5 (MEF2A) T311 HPRD 10849446, 9858528
Q02078 (MEF2A) T312 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9858528
Q02078 (MEF2A) T319 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9858528
Q02078 (MEF2A) S355 neXtProt 9858528
Q02078 (MEF2A) S408 phospho.ELM   PhosphoSitePlus   Signor 12586839
Q02078-5 (MEF2A) S445 HPRD 9858528
Q02078 (MEF2A) S453 neXtProt   phospho.ELM   Signor 12586839, 9858528
Q02078 (MEF2A) S479 neXtProt   PhosphoSitePlus 12586839, 9858528
Q02078 (MEF2A) S494 PhosphoSitePlus 12586839
Q02156 (PRKCE) S350 neXtProt   PhosphoSitePlus 18604201
Q06330 (RBPJ) T339 PhosphoSitePlus 22302987
Q06413-3 (MEF2C) T293 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9858528, 10805738, 9069290
Q06413-1 (MEF2C) T300 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9858528, 9069290
Q06413-1 (MEF2C) S387 HPRD   neXtProt   PhosphoSitePlus   Signor 9858528, 9069290
Q07666 (KHDRBS1) S58 phospho.ELM 12478298
Q07666 (KHDRBS1) T84 phospho.ELM 12478298
Q07817 (BCL2L1) S62 PhosphoSitePlus 22617334
Q12778 (FOXO1) S416 neXtProt 17113751
Q12778 (FOXO1) S432 neXtProt 17113751
Q12778 (FOXO1) S470 neXtProt 17113751
Q12778 (FOXO1) T478 neXtProt 17113751
Q12778 (FOXO1) T560 neXtProt 17113751
Q13541 (EIF4EBP1) T37 HPRD   neXtProt   Signor 11777913, 19413330, 19664995, ...19651622, 18669648, 20068231
Q13541 (EIF4EBP1) T46 HPRD   neXtProt   Signor 11777913, 19413330, 19664995, ...19651622, 18669648, 20068231
Q13541 (EIF4EBP1) S65 HPRD   neXtProt   Signor 11777913, 17287340, 18767875, ...19664995, 19651622, 18669648, 20068231
Q13541 (EIF4EBP1) T70 neXtProt 11777913
Q14721 (KCNB1) S805 neXtProt   PhosphoSitePlus 22745487, 17360683
Q14765 (STAT4) S721 HPRD   neXtProt   Signor 10961885, 17502367
Q14790 (CASP8) S347 phospho.ELM   PhosphoSitePlus   Signor 14970175
Q14934 (NFATC4) S168 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 11997522
Q14934 (NFATC4) S170 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 11997522
Q15046 (KARS1) T52 PhosphoSitePlus 22751010
Q15075 (EEA1) T1392 HPRD   neXtProt   PhosphoSitePlus 16138080
Q15596 (NCOA2) S736 neXtProt 16410316
Q15672 (TWIST1) S68 neXtProt   PhosphoSitePlus   Signor 21502402
Q15717 (ELAVL1) T118 neXtProt   PhosphoSitePlus   Signor 19528229, 21862584
Q15750 (TAB1) S423 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19393267, 14592977
Q15750 (TAB1) T431 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19393267, 14592977
Q15750 (TAB1) S438 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14592977
Q15750 (TAB1) S452 PhosphoSitePlus 22216226
Q15750 (TAB1) S453 PhosphoSitePlus 22216226
Q15750 (TAB1) S456 PhosphoSitePlus 22216226
Q15750 (TAB1) S457 PhosphoSitePlus 22216226
Q15910 (EZH2) T367 PhosphoSitePlus 20887952
Q16539 (MAPK14) T180 neXtProt   UniProt 15735648, 18669648
Q16539 (MAPK14) Y182 neXtProt   UniProt 15735648, 18669648
Q86UR1 (NOXA1) S239 neXtProt   PhosphoSitePlus 20110267
Q86UR1 (NOXA1) S282 neXtProt   PhosphoSitePlus 20110267
Q8IW41-1 (MAPKAPK5) T182 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18669648, 9628874
Q8NHW3 (MAFA) S14 HPRD 11416124
Q8NHW3 (MAFA) T57 PhosphoSitePlus 23660596
Q8NHW3 (MAFA) T134 PhosphoSitePlus 23660596
Q8TDD2 (SP7) S76 neXtProt 20682789
Q8TDD2 (SP7) S80 neXtProt 20682789
Q8WYK2 (JDP2) T148 HPRD   neXtProt   PhosphoSitePlus 12225289, 11602244
Q92945 (KHSRP) T692 neXtProt   PhosphoSitePlus 16364914
Q92993-2 (KAT5) T106 PhosphoSitePlus 23685072
Q92993 (KAT5) T158 PhosphoSitePlus 23685072
Q99460 (PSMD1) T273 neXtProt 21044959
Q99626 (CDX2) S283 neXtProt   PhosphoSitePlus   Signor 16027724
Q99626 (CDX2) S287 Signor 16027724
Q99626 (CDX2) S291 Signor 16027724
Q99626 (CDX2) S295 Signor 16027724
Q9BR76 (CORO1B) S2 RLIMS-P+ 27592029
Q9BUB5-2 (MKNK1) T209 PhosphoSitePlus 17590453
Q9BUB5-2 (MKNK1) T214 PhosphoSitePlus 17590453
Q9BUB5 (MKNK1) T250 neXtProt   PhosphoSitePlus   Signor 17590453, 9155017
Q9BUB5 (MKNK1) T255 neXtProt   PhosphoSitePlus   Signor 17130135, 17590453, 9155017
Q9H1K0 (RBSN) S215 HPRD   neXtProt   PhosphoSitePlus   Signor 16138080, 20068231
Q9NQU5 (PAK6) S165 phospho.ELM   PhosphoSitePlus   Signor 15550393
Q9NRR4 (DROSHA) S221 PhosphoSitePlus 25699712
Q9NRR4 (DROSHA) S255 PhosphoSitePlus 25699712
Q9NRR4 (DROSHA) T274 PhosphoSitePlus 25699712
Q9NRR4 (DROSHA) S300 PhosphoSitePlus 25699712
Q9NRR4 (DROSHA) S355 PhosphoSitePlus 25699712
Q9UBK2-1 (PPARGC1A) T263 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11741533
Q9UBK2-1 (PPARGC1A) S266 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11741533
Q9UBK2 (PPARGC1A) T299 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11741533
Q9UIG0 (BAZ1B) S158 PhosphoSitePlus   Signor 19776015
Q9UL54-2 (TAOK2) S1031 neXtProt 17988630
Q9UQD0 (SCN8A) S553 neXtProt 16014723
Q9Y5Y9 (SCN10A) S552 neXtProt 18354022
Q9Y698 (CACNG2) T321 neXtProt 19968761
Q9Y6Q9 (NCOA3) T24 neXtProt 15383283
Q9Y6Q9-1 (NCOA3) S505 HPRD   neXtProt   PhosphoSitePlus   Signor 16135815, 15383283, 16456540
Q9Y6Q9-5 (NCOA3) S543 HPRD   neXtProt   PhosphoSitePlus   Signor 16135815, 15383283, 16456540
Q9Y6Q9 (NCOA3) S860 HPRD   neXtProt   PhosphoSitePlus   Signor 16135815, 16456540, 20068231, ...15383283
Q9Y6Q9-5 (NCOA3) S867 HPRD   neXtProt   PhosphoSitePlus   Signor 19413330, 16964243, 16135815, ...15383283, 18669648, 16456540, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048320 (hMAPK14/InitMet-/Phos:1) pT180,pY182 PRO
PR:000036637 (hMAPK14/Phos:1) pT180,pY182 PRO 15642743


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04150 (NR3C1) S211 Q16539 (MAPK14) unknown eFIP 22285804
Phosphorylation Q16539 (MAPK14) Y182 P07900 (HSP90AA1) unknown eFIP 33663544


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036637 (hMAPK14/Phos:1) Interaction PR:000036624 (hTP53/iso:1/Phos:2) PRO 15642743


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y9 * Biomuta DOID:1319 / brain cancer [ icgc, icgc ] DOID:2531 / hematologic cancer [ cosmic, cosmic, cosmic ]
T16 A16 Biomuta DOID:1319 / brain cancer [ icgc ]
R49 H49 Biomuta DOID:363 / uterine cancer [ icgc ]
K121 T121 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R149 K149 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T185 I185 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K248 N248 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K249 T249 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]