iPTMnet Report for Q16537 (PPP2R5E)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16537 / 2A5E_HUMAN
Protein Name Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
Gene Name Name: PPP2R5E
Organism Homo sapiens (Human)

PRO ID PR:Q16537
DAG View
PRO Name serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (human)
Definition A serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform that is encoded in the genome of human.
Short Label hPPP2R5E
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16537 (PPP2R5E) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
T7 Phosphorylation PhosphoSitePlus   UniProt 23186163
S10 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus   UniProt 21406692
S32 Phosphorylation PhosphoSitePlus   UniProt 21406692
S33 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus   UniProt 21406692
S38 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
C121 Methylation IEDB 31844290
K173 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
T299 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K449 Methylation PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation HPRD 18691976
S34 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 P10 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S30 L30 Biomuta DOID:4159 / skin cancer [ cosmic ]
S33 F33 Biomuta DOID:4159 / skin cancer [ cosmic ]
S34 L34 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S38 F38 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S103 T103 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C121 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K209 R209 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]