iPTMnet Report for Q16531 (DDB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16531 / DDB1_HUMAN
Protein Name DNA damage-binding protein 1
Gene Name Name: DDB1
Synonyms:XAP1;
Organism Homo sapiens (Human)

PRO ID PR:Q16531
DAG View
PRO Name DNA damage-binding protein 1 (human)
Definition A DNA damage-binding protein 1 that is encoded in the genome of human.
Short Label hDDB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16531 (DDB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
Y42 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
T81 Phosphorylation PhosphoSitePlus
C87 Methylation IEDB 31844290
K92 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
R147 Methylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K153 Acetylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
T294 Phosphorylation PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
C313 Methylation IEDB 31844290
Y316 Phosphorylation PhosphoSitePlus   RLIMS-P 28087699
S331 Phosphorylation PhosphoSitePlus
S345 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 34725712, 29351928, 34019948, 32119511, 33465208
K383 Acetylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
S480 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 34725712, 29351928, 34019948, 32119511, 33465208
K484 Ubiquitination PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
C540 Methylation IEDB 31844290
K570 Ubiquitination PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
C604 Methylation IEDB 31844290
K628 Ubiquitination PhosphoSitePlus
T636 Phosphorylation PhosphoSitePlus
T640 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus 25982117
S645 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 25982117
T646 Phosphorylation PhosphoSitePlus
C652 Methylation IEDB 31844290
T657 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 34725712, 29351928, 34019948, 32119511, 33465208
Y660 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
T714 Phosphorylation PhosphoSitePlus
Y718 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
K723 Ubiquitination PhosphoSitePlus
C725 Methylation IEDB 31844290
C732 Methylation IEDB 31844290
S755 Phosphorylation PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus
C819 Methylation IEDB 31844290
K823 Ubiquitination PhosphoSitePlus
Y828 Phosphorylation PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
K857 Ubiquitination PhosphoSitePlus
T860 Phosphorylation PhosphoSitePlus
K864 Acetylation PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
Y871 Phosphorylation PhosphoSitePlus
K897 Ubiquitination PhosphoSitePlus
C903 Methylation IEDB 31844290
K917 Ubiquitination PhosphoSitePlus
K936 Ubiquitination PhosphoSitePlus
K1067 Acetylation PhosphoSitePlus   UniProt 19608861
K1067 Ubiquitination PhosphoSitePlus
K1081 Ubiquitination PhosphoSitePlus
S1101 Phosphorylation PhosphoSitePlus
K1104 Ubiquitination PhosphoSitePlus
K1121 Acetylation PhosphoSitePlus
K1121 Ubiquitination PhosphoSitePlus
T1125 Phosphorylation PhosphoSitePlus
K1131 Ubiquitination PhosphoSitePlus
T1137 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation HPRD 20068231
T633 Phosphorylation HPRD 20068231
T636 Phosphorylation HPRD 20068231
S757 Phosphorylation HPRD 20068231
S763 Phosphorylation HPRD 20068231
S764 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O94761 (RECQL4) S251 Q16531 (DDB1) increased_association eFIP 29229926


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 W2 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y42 H42 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y42 C42 Biomuta DOID:4159 / skin cancer [ cosmic ]
C87 S87 Biomuta DOID:1324 / lung cancer [ cosmic ]
R147 C147 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R147 H147 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y182 C182 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K254 N254 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T294 I294 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K298 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S345 C345 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
C540 G540 Biomuta DOID:4159 / skin cancer [ cosmic ]
S573 F573 Biomuta [ cosmic ]
T646 I646 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y660 H660 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C725 * Biomuta [ cosmic ]
S781 F781 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
S854 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S854 L854 Biomuta DOID:363 / uterine cancer [ icgc ]
K1067 N1067 Biomuta [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
K1131 N1131 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1131 E1131 Biomuta DOID:9256 / colorectal cancer [ cosmic ]