iPTMnet Report for Q16526 (CRY1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16526 / CRY1_HUMAN
Protein Name Cryptochrome-1
Gene Name Name: CRY1
Synonyms:PHLL1;
Organism Homo sapiens (Human)

PRO ID PR:Q16526
DAG View
PRO Name cryptochrome-1 (human)
Definition A cryptochrome-1 that is encoded in the genome of human.
Short Label hCRY1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16526 (CRY1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Ubiquitination PRO
S71 Phosphorylation neXtProt   RLIMS-P   Signor 21892142, 30500822, 19833968
S71 Phosphorylation Q13131 (PRKAA1) Signor 21892142
K89 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K151 Acetylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
S247 Phosphorylation neXtProt 15298678
S247 Phosphorylation P28482 (MAPK1) neXtProt 15298678
C259 Methylation IEDB 31844290
S280 Phosphorylation neXtProt   RLIMS-P 30500822, 19833968
S285 Phosphorylation PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
Y432 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K442 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
Y494 Phosphorylation HPRD 18083107
S568 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047073 (hCRY1/PhosSer+) p PRO
PR:000047074 (hCRY1/pSerUbiq+) p PRO
PR:000047074 (hCRY1/pSerUbiq+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K89 E89 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K228 N228 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S492 L492 Biomuta DOID:4159 / skin cancer [ cosmic ]
S568 N568 Biomuta DOID:363 / uterine cancer [ icgc ]