iPTMnet Report for Q16518 (RPE65)
Protein Information
| UniProt AC / UniProt ID | Q16518 / RPE65_HUMAN |
| Protein Name | Retinoid isomerohydrolase |
| Gene Name | Name: RPE65 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q16518 |
| PRO Name | retinoid isomerohydrolase (human) |
| Definition | A retinal pigment epithelium-specific 65 kDa protein that is encoded in the genome of human. |
| Short Label | hRPE65 |
| Category | organism-gene |
DAG ViewQ16518 (RPE65) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T18 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y89 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T101 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 19049981 | ||
| T105 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 19049981 | ||
| K113 | Acetylation | score3 | PhosphoSitePlus UniProt | 19049981 | ||
| S117 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 19049981 | ||
| Y304 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K376 | Acetylation | score1 | PhosphoSitePlus | |||
| T379 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T18 | I18 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K113 | N113 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S117 | Y117 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S117 | F117 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
| Y304 | H304 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K376 | N376 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |
