iPTMnet Report Q16512 PKN1

Protein Information

UniProt AC / UniProt ID	Q16512 / PKN1_HUMAN
Protein Name	Serine/threonine-protein kinase N1
Gene Name	Name: PKN1 Synonyms:PAK1,PKN,PRK1,PRKCL1;
Organism	Homo sapiens (Human)

PRO ID	PR:Q16512 DAG View
PRO Name	serine/threonine-protein kinase N1 (human)
Definition	A serine/threonine-protein kinase N1 that is encoded in the genome of human.
Short Label	hPKN1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q16512 (PKN1) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
A2	Acetylation		score1	UniProt	19413330, 22814378
S3	Phosphorylation		score1	PhosphoSitePlus
S8	Phosphorylation		score1	PhosphoSitePlus
K53	Ubiquitination		score1	PhosphoSitePlus
T63	Phosphorylation		score1	PhosphoSitePlus
T64	Phosphorylation	Q16512 (PKN1)	score4	neXtProt PhosphoSitePlus RLIMS-P	10467162, 10441506, 8943281
S69	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S80	Phosphorylation		score1	PhosphoSitePlus
S112	Phosphorylation		score1	PhosphoSitePlus
N154	N-Glycosylation		score1	GlyGen	29741879
S205	Phosphorylation		score2	PhosphoSitePlus UniProt	18691976, 19690332
S240	Phosphorylation		score1	PhosphoSitePlus
K243	Ubiquitination		score1	PhosphoSitePlus
K256	Ubiquitination		score1	PhosphoSitePlus
K263	Ubiquitination		score1	PhosphoSitePlus
S301	Phosphorylation		score1	PhosphoSitePlus
T311	Phosphorylation		score1	PhosphoSitePlus
T315	Phosphorylation		score1	PhosphoSitePlus
T353	Phosphorylation		score1	PhosphoSitePlus
R357	Methylation		score1	PhosphoSitePlus
R366	Methylation		score1	PhosphoSitePlus
S372	Phosphorylation		score1	PhosphoSitePlus
S374	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	10467162
S376	Phosphorylation	Q16512 (PKN1)	score4	neXtProt phospho.ELM	10441506, 17081983, 8943281
S379	Phosphorylation		score1	PhosphoSitePlus
S380	Phosphorylation		score1	PhosphoSitePlus
K445	Ubiquitination		score1	PhosphoSitePlus
K448	Acetylation		score2	PhosphoSitePlus UniProt	19608861
S495	Phosphorylation		score2	IEDB PhosphoSitePlus	32897882, 27869121
K496	Ubiquitination		score1	PhosphoSitePlus
T527	Phosphorylation		score1	PhosphoSitePlus
T529	Phosphorylation		score1	PhosphoSitePlus
T531	Phosphorylation		score0	RLIMS-P	10467162
S533	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	23186163, 16964243, 18669648, ...19690332, 20068231
S537	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 23186163, 18669648, ...19690332, 20068231
S540	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S549	Phosphorylation		score1	PhosphoSitePlus
T557	Phosphorylation		score1	PhosphoSitePlus
S559	O-Glycosylation		score1	GlyGen	29351928
S559	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 19690332
S561	O-Glycosylation		score1	GlyGen	29351928
S561	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	30206226
S562	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	21406692, 23186163, 16964243, ...17192257, 18669648, 30206226, 19690332, 20068231
K565	Ubiquitination		score1	PhosphoSitePlus
S573	Phosphorylation		score1	PhosphoSitePlus
S575	Phosphorylation		score1	PhosphoSitePlus
S576	Phosphorylation		score1	PhosphoSitePlus
K607	Ubiquitination		score1	PhosphoSitePlus
S608	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
T611	Phosphorylation		score1	PhosphoSitePlus
K644	Ubiquitination		score1	PhosphoSitePlus
K664	Ubiquitination		score1	PhosphoSitePlus
C692	Methylation		score1	IEDB	31844290
K742	Ubiquitination		score1	PhosphoSitePlus
K763	Ubiquitination		score1	PhosphoSitePlus
Y768	Phosphorylation		score1	PhosphoSitePlus
T772	Phosphorylation		score1	PhosphoSitePlus
S773	Phosphorylation	O15530 (PDPK1)	score2	PhosphoSitePlus	10792047
T774	Phosphorylation	Q16512 (PKN1) , O15530 (PDPK1)	score4	neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	24114839, 10467162, 10753910, ...18669648, 22893700, 10792047
T778	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 18220336
R847	Methylation		score1	PhosphoSitePlus
S902	Phosphorylation		score1	PhosphoSitePlus
T914	Phosphorylation		score2	PhosphoSitePlus UniProt	19690332
S916	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	23186163, 15302935, 17192257, ...18669648, 24275569, 19690332
T925	Phosphorylation		score1	PhosphoSitePlus

Site	PTM Type	PTM Enzyme	Score	Source	PMID
T64	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10467162
S205	Phosphorylation		score0	HPRD	18691976
S240	Phosphorylation		score0	HPRD	19664994
T353	Phosphorylation		score0	HPRD	18691976
S372	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10792047
S374	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10467162
S376	Phosphorylation		score0	HPRD	17081983
S380	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10467162
T531	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10467162
S533	Phosphorylation		score0	HPRD	19413330, 18691976, 18669648, ...16964243, 20068231
S537	Phosphorylation		score0	HPRD	19413330, 18691976, 18669648, ...20068231
T557	Phosphorylation		score0	HPRD	18691976
S559	Phosphorylation		score0	HPRD	17322306, 18691976, 18669648, ...19413330, 19415658
S561	Phosphorylation		score0	HPRD	19413330, 18691976, 19651622, ...19664995, 20068231
S562	Phosphorylation		score0	HPRD	19413330, 18691976, 16964243, ...18767875, 19664994, 19664995, 19651622, 17322306, 18669648, 19415658, 20068231
S576	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10792047
S608	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10792047
T772	Phosphorylation		score0	HPRD	18691976
T774	Phosphorylation	O15530 (PDPK1)	score2	HPRD	10753910, 10792047, 18669648
T778	Phosphorylation		score0	HPRD	18669648
S902	Phosphorylation		score0	HPRD	20058876
T914	Phosphorylation		score0	HPRD	20058876, 18452278
S916	Phosphorylation		score0	HPRD	19413330, 18691976, 20058876, ...15302935, 19664994, 18452278, 18669648, 18707149

Site	PTM Type	PTM Enzyme	Score	Source	PMID
T70	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10467162
S211	Phosphorylation		score0	HPRD	18691976
S246	Phosphorylation		score0	HPRD	19664994
T359	Phosphorylation		score0	HPRD	18691976
S378	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10792047
S380	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10467162
S382	Phosphorylation		score0	HPRD	17081983
T537	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10467162
S539	Phosphorylation		score0	HPRD	19413330, 18691976, 18669648, ...16964243, 20068231
S543	Phosphorylation		score0	HPRD	19413330, 18691976, 18669648, ...20068231
T563	Phosphorylation		score0	HPRD	18691976
S565	Phosphorylation		score0	HPRD	17322306, 18691976, 18669648, ...19413330, 19415658
S567	Phosphorylation		score0	HPRD	19413330, 18691976, 19651622, ...19664995, 20068231
S568	Phosphorylation		score0	HPRD	19413330, 18691976, 16964243, ...18767875, 19664994, 19664995, 19651622, 17322306, 18669648, 19415658, 20068231
S582	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10792047
S614	Phosphorylation	Q16512 (PKN1)	score1	HPRD	10792047
T778	Phosphorylation		score0	HPRD	18691976
T780	Phosphorylation	O15530 (PDPK1)	score2	HPRD	10792047, 18669648
T784	Phosphorylation		score0	HPRD	18669648
S908	Phosphorylation		score0	HPRD	20058876
T920	Phosphorylation		score0	HPRD	20058876, 18452278
S922	Phosphorylation		score0	HPRD	19413330, 18691976, 20058876, ...15302935, 19664994, 18452278, 18669648, 18707149

Q16512 (PKN1) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O95863 (SNAI1)	S246	score1	Signor	15833848
P00533 (EGFR)	T678	score3	neXtProt PhosphoSitePlus Signor	21749319
P04049 (RAF1)	S338	score1	Signor	11733498
P04049 (RAF1)	S339	score1	Signor	15849194
P10636-6 (MAPT)	T147	score2	HPRD	19413330, 9546672, 11181841, ...19562805, 9199504, 12226093, 12387894, 9565682, 9832145, 9771888, 12435421
P10636-2 (MAPT)	S156	score2	HPRD	12435421, 9832145, 11104762, ...12387894, 9546672
P10636-2 (MAPT)	S200	score1	HPRD	11104762
P10636-8 (MAPT)	S214	score4	HPRD PhosphoSitePlus	12435421, 9832145, 11104762, ...12387894, 9546672
P10636-2 (MAPT)	S231	score2	HPRD	9199504, 11104762
P10636-8 (MAPT)	S258	score3	HPRD PhosphoSitePlus	11104762
P10636-6 (MAPT)	S262	score2	HPRD	9199504, 11104762
P10636-2 (MAPT)	S263	score1	HPRD	11104762
P10636-6 (MAPT)	S294	score1	HPRD	11104762
P10636-8 (MAPT)	S320	score4	HPRD PhosphoSitePlus	9199504, 11104762
P10636-8 (MAPT)	S352	score3	HPRD PhosphoSitePlus	11104762
P10636 (MAPT)	S637	score1	Signor	11104762
P18669 (PGAM1)	S23	score1	Signor	12189148
P18669 (PGAM1)	S118	score1	Signor	12189148
P29966 (MARCKS)	S159	score2	HPRD	18767875, 8557118, 11930178, ...20068231
P29966 (MARCKS)	S163	score2	HPRD	18669648, 17287340, 11930178, ...20068231, 8557118
P29966 (MARCKS)	S170	score0	HPRD	19413330, 17322306, 18578522, ...17287340, 18212344, 18767875, 20058876, 19664995, 19651622, 18669648, 18707149, 20166139, 20068231
P30307 (CDC25C)	S216	score4	HPRD neXtProt Signor	9543386, 10557092, 9278512, ...15791647, 11333986, 11551930, 20068231
P30622 (CLIP1)	S312	score3	neXtProt PhosphoSitePlus	21749319
P36871 (PGM1)	T467	score1	Signor	15378030
Q12778 (FOXO1)	S256	score1	Signor	12560069
Q13077 (TRAF1)	S146	score2	neXtProt	18429822
Q16512-1 (PKN1)	T64	score4	HPRD neXtProt	10467162, 10441506, 8943281
Q16512-2 (PKN1)	T70	score1	HPRD	10467162
Q16512-1 (PKN1)	S372	score1	HPRD	10792047
Q16512-1 (PKN1)	S374	score1	HPRD	10467162
Q16512 (PKN1)	S376	score3	neXtProt	10441506, 8943281
Q16512-2 (PKN1)	S378	score1	HPRD	10792047
Q16512-2 (PKN1)	S380	score1	HPRD	10467162
Q16512-1 (PKN1)	T531	score1	HPRD	10467162
Q16512-2 (PKN1)	T537	score1	HPRD	10467162
Q16512-1 (PKN1)	S576	score1	HPRD	10792047
Q16512-2 (PKN1)	S582	score1	HPRD	10792047
Q16512-1 (PKN1)	S608	score1	HPRD	10792047
Q16512-2 (PKN1)	S614	score1	HPRD	10792047
Q16512 (PKN1)	T774	score2	PhosphoSitePlus	10467162
Q92974 (ARHGEF2)	S886	score1	Signor	14970201
Q9UKV0 (HDAC9)	S253	score2	PhosphoSitePlus	20188095
Q9UQL6 (HDAC5)	T292	score3	neXtProt PhosphoSitePlus	20188095

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000048785 (hPKN1/InitMet-/Phos:1)	pT774		PRO

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
N154	I154	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K263	N263	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
R366	W366	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
R366	Q366	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S380	R380	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K445	T445	Biomuta	DOID:363 / uterine cancer [ icgc ]
K448	M448	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
K496	*	Biomuta	DOID:263 / kidney cancer [ cosmic ]
T527	M527	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T531	I531	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]
T537	I537	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]
S540	F540	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T557	I557	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
T563	I563	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S573	N573	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
S575	L575	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S576	N576	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S582	N582	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S608	L608	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
T611	P611	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
S614	L614	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
T778	A778	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
T784	A784	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q16512 (PKN1)

Protein Information

Interactive Sequence View

Q16512 (PKN1) as Substrate

Q16512 (PKN1) as PTM Enzyme

Proteoforms

PTM sites affected in variants