Protein Information

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UniProt AC / UniProt ID Q16512 / PKN1_HUMAN
Protein Name Serine/threonine-protein kinase N1
Gene Name Name: PKN1
Synonyms:PAK1,PKN,PRK1,PRKCL1;
Organism Homo sapiens (Human)

PRO ID PR:Q16512
DAG View
PRO Name serine/threonine-protein kinase N1 (human)
Definition A serine/threonine-protein kinase N1 that is encoded in the genome of human.
Short Label hPKN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16512 (PKN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
S3 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus
T64 Phosphorylation Q16512 (PKN1) neXtProt   PhosphoSitePlus   RLIMS-P 10467162, 10441506, 8943281
S69 Phosphorylation PhosphoSitePlus   UniProt 23186163
S80 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19690332
S240 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
R357 Methylation PhosphoSitePlus
R366 Methylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus   RLIMS-P 10467162
S376 Phosphorylation Q16512 (PKN1) neXtProt   phospho.ELM 10441506, 17081983, 8943281
S379 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
K448 Acetylation PhosphoSitePlus   UniProt 19608861
S495 Phosphorylation PhosphoSitePlus
T527 Phosphorylation PhosphoSitePlus
T529 Phosphorylation PhosphoSitePlus
T531 Phosphorylation RLIMS-P 10467162
S533 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...19690332, 20068231
S537 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18669648, ...19690332, 20068231
S540 Phosphorylation PhosphoSitePlus   UniProt 23186163
S549 Phosphorylation PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
S559 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S561 Phosphorylation PhosphoSitePlus
S562 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...17192257, 18669648, 19690332, 20068231
S573 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus   UniProt 23186163
T611 Phosphorylation PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
Y768 Phosphorylation PhosphoSitePlus
T772 Phosphorylation PhosphoSitePlus
S773 Phosphorylation O15530 (PDPK1) PhosphoSitePlus 10792047
T774 Phosphorylation Q16512 (PKN1) , O15530 (PDPK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24114839, 10467162, 10753910, ...18669648, 22893700, 10792047
T778 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
R847 Methylation PhosphoSitePlus
S902 Phosphorylation PhosphoSitePlus
T914 Phosphorylation PhosphoSitePlus   UniProt 19690332
S916 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 17192257, ...18669648, 24275569, 19690332
T925 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T64 Phosphorylation Q16512 (PKN1) HPRD 10467162
S205 Phosphorylation HPRD 18691976
S240 Phosphorylation HPRD 19664994
T353 Phosphorylation HPRD 18691976
S372 Phosphorylation Q16512 (PKN1) HPRD 10792047
S374 Phosphorylation Q16512 (PKN1) HPRD 10467162
S376 Phosphorylation HPRD 17081983
S380 Phosphorylation Q16512 (PKN1) HPRD 10467162
T531 Phosphorylation Q16512 (PKN1) HPRD 10467162
S533 Phosphorylation HPRD 19413330, 18691976, 18669648, ...16964243, 20068231
S537 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
T557 Phosphorylation HPRD 18691976
S559 Phosphorylation HPRD 17322306, 18691976, 18669648, ...19413330, 19415658
S561 Phosphorylation HPRD 19413330, 18691976, 19651622, ...19664995, 20068231
S562 Phosphorylation HPRD 19413330, 18691976, 16964243, ...18767875, 19664994, 19664995, 19651622, 17322306, 18669648, 19415658, 20068231
S576 Phosphorylation Q16512 (PKN1) HPRD 10792047
S608 Phosphorylation Q16512 (PKN1) HPRD 10792047
T772 Phosphorylation HPRD 18691976
T774 Phosphorylation O15530 (PDPK1) HPRD 10753910, 10792047, 18669648
T778 Phosphorylation HPRD 18669648
S902 Phosphorylation HPRD 20058876
T914 Phosphorylation HPRD 20058876, 18452278
S916 Phosphorylation HPRD 19413330, 18691976, 20058876, ...15302935, 19664994, 18452278, 18669648, 18707149
Site PTM Type PTM Enzyme Score Source PMID
T70 Phosphorylation Q16512 (PKN1) HPRD 10467162
S211 Phosphorylation HPRD 18691976
S246 Phosphorylation HPRD 19664994
T359 Phosphorylation HPRD 18691976
S378 Phosphorylation Q16512 (PKN1) HPRD 10792047
S380 Phosphorylation Q16512 (PKN1) HPRD 10467162
S382 Phosphorylation HPRD 17081983
T537 Phosphorylation Q16512 (PKN1) HPRD 10467162
S539 Phosphorylation HPRD 19413330, 18691976, 18669648, ...16964243, 20068231
S543 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
T563 Phosphorylation HPRD 18691976
S565 Phosphorylation HPRD 17322306, 18691976, 18669648, ...19413330, 19415658
S567 Phosphorylation HPRD 19413330, 18691976, 19651622, ...19664995, 20068231
S568 Phosphorylation HPRD 19413330, 18691976, 16964243, ...18767875, 19664994, 19664995, 19651622, 17322306, 18669648, 19415658, 20068231
S582 Phosphorylation Q16512 (PKN1) HPRD 10792047
S614 Phosphorylation Q16512 (PKN1) HPRD 10792047
T778 Phosphorylation HPRD 18691976
T780 Phosphorylation O15530 (PDPK1) HPRD 10792047, 18669648
T784 Phosphorylation HPRD 18669648
S908 Phosphorylation HPRD 20058876
T920 Phosphorylation HPRD 20058876, 18452278
S922 Phosphorylation HPRD 19413330, 18691976, 20058876, ...15302935, 19664994, 18452278, 18669648, 18707149


Q16512 (PKN1) as PTM Enzyme



Substrate Site Score Source PMID
O95863 (SNAI1) S246 Signor 15833848
P00533 (EGFR) T678 neXtProt   PhosphoSitePlus   Signor 21749319
P04049 (RAF1) S338 Signor 11733498
P04049 (RAF1) S339 Signor 15849194
P10636-6 (MAPT) T147 HPRD 19413330, 9546672, 11181841, ...19562805, 9199504, 12226093, 12387894, 9565682, 9832145, 9771888, 12435421
P10636-2 (MAPT) S156 HPRD 12435421, 9832145, 11104762, ...12387894, 9546672
P10636-2 (MAPT) S200 HPRD 11104762
P10636-8 (MAPT) S214 HPRD   PhosphoSitePlus 12435421, 9832145, 11104762, ...12387894, 9546672
P10636-2 (MAPT) S231 HPRD 9199504, 11104762
P10636-8 (MAPT) S258 HPRD   PhosphoSitePlus 11104762
P10636-6 (MAPT) S262 HPRD 9199504, 11104762
P10636-2 (MAPT) S263 HPRD 11104762
P10636-6 (MAPT) S294 HPRD 11104762
P10636-8 (MAPT) S320 HPRD   PhosphoSitePlus 9199504, 11104762
P10636-8 (MAPT) S352 HPRD   PhosphoSitePlus 11104762
P10636 (MAPT) S637 Signor 11104762
P18669 (PGAM1) S23 Signor 12189148
P18669 (PGAM1) S118 Signor 12189148
P29966 (MARCKS) S159 HPRD 18767875, 8557118, 11930178, ...20068231
P29966 (MARCKS) S163 HPRD 18669648, 17287340, 11930178, ...20068231, 8557118
P29966 (MARCKS) S170 HPRD 19413330, 17322306, 18578522, ...17287340, 18212344, 18767875, 20058876, 19664995, 19651622, 18669648, 18707149, 20166139, 20068231
P30307 (CDC25C) S216 HPRD   neXtProt   Signor 9543386, 10557092, 9278512, ...15791647, 11333986, 11551930, 20068231
P30622 (CLIP1) S312 neXtProt   PhosphoSitePlus 21749319
P36871 (PGM1) T467 Signor 15378030
Q12778 (FOXO1) S256 Signor 12560069
Q13077 (TRAF1) S146 neXtProt 18429822
Q16512-1 (PKN1) T64 HPRD   neXtProt 10467162, 10441506, 8943281
Q16512-2 (PKN1) T70 HPRD 10467162
Q16512-1 (PKN1) S372 HPRD 10792047
Q16512-1 (PKN1) S374 HPRD 10467162
Q16512 (PKN1) S376 neXtProt 10441506, 8943281
Q16512-2 (PKN1) S378 HPRD 10792047
Q16512-1 (PKN1) S380 HPRD 10467162
Q16512-1 (PKN1) T531 HPRD 10467162
Q16512-2 (PKN1) T537 HPRD 10467162
Q16512-1 (PKN1) S576 HPRD 10792047
Q16512-2 (PKN1) S582 HPRD 10792047
Q16512-1 (PKN1) S608 HPRD 10792047
Q16512-2 (PKN1) S614 HPRD 10792047
Q16512 (PKN1) T774 PhosphoSitePlus 10467162
Q92974 (ARHGEF2) S886 Signor 14970201
Q9UKV0 (HDAC9) S253 PhosphoSitePlus 20188095
Q9UQL6 (HDAC5) T292 neXtProt   PhosphoSitePlus 20188095


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048785 (hPKN1/InitMet-/Phos:1) pT774 PRO