iPTMnet Report Q16288 NTRK3

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q16288 / NTRK3_HUMAN
Protein Name	NT-3 growth factor receptor precursor
Gene Name	Name: NTRK3 Synonyms:TRKC;
Organism	Homo sapiens (Human)

PRO ID	PR:Q16288 DAG View
PRO Name	NT-3 growth factor receptor (human)
Definition	An NT-3 growth factor receptor that is encoded in the genome of human.
Short Label	hNTRK3
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q16288 (NTRK3) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y131	Phosphorylation		score1	PhosphoSitePlus
	T220	Phosphorylation		score1	PhosphoSitePlus
	T386	Phosphorylation		score1	PhosphoSitePlus
	Y516	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	11877382, 26216473, 25196463
	Y516	Phosphorylation	Q16288 (NTRK3)	score2	UniProt	25196463
	Y558	Phosphorylation		score1	PhosphoSitePlus
	S701	Phosphorylation		score1	PhosphoSitePlus
	Y705	Phosphorylation		score1	PhosphoSitePlus
	Y709	Phosphorylation		score3	IntAct PhosphoSitePlus	12237455
	Y710	Phosphorylation		score1	PhosphoSitePlus
	Y800	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y597	Phosphorylation		score1	PhosphoSitePlus
	Y604	Phosphorylation		score1	PhosphoSitePlus
	S606	Phosphorylation		score1	PhosphoSitePlus

Q16288 (NTRK3) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	Q16288 (NTRK3)	Y516	score2	UniProt	25196463

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
Y516	H516	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
Y558	C558	Biomuta		DOID:10534 / stomach cancer [ cosmic ]
S701	F701	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S701	T701	Biomuta		DOID:3571 / liver cancer [ cosmic, icgc ]
Y705	H705	Biomuta		DOID:8618 / oral cavity cancer [ cosmic ]
Y705	N705	Biomuta		DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y709	F709	Biomuta		[ cosmic ]
Y710	H710	Biomuta		DOID:1324 / lung cancer [ cosmic ]
Y800	H800	Biomuta		DOID:4159 / skin cancer [ cosmic ]
Y800	C800	Biomuta		DOID:10534 / stomach cancer [ cosmic ]