iPTMnet Report for Q16254 (E2F4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16254 / E2F4_HUMAN
Protein Name Transcription factor E2F4
Gene Name Name: E2F4
Organism Homo sapiens (Human)

PRO ID PR:Q16254
DAG View
PRO Name transcription factor E2F4 (human)
Definition A transcription factor E2F4 that is encoded in the genome of human.
Short Label hE2F4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16254 (E2F4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
T14 Phosphorylation PhosphoSitePlus   RLIMS-P 23919615
S16 Phosphorylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
Y59 Phosphorylation PhosphoSitePlus
S75 Phosphorylation RLIMS-P 29995440
K82 Ubiquitination PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
S202 Phosphorylation RLIMS-P 23919615
S218 Phosphorylation RLIMS-P 23919615
T224 Phosphorylation RLIMS-P 23919615
S244 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   RLIMS-P 23919615
T248 Phosphorylation RLIMS-P 23919615
S309 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
C362 Methylation IEDB 31844290
S384 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   RLIMS-P   UniProt 23919615, 24275569


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036473 (hRBL2/iso:1/Phos:3) Interaction PR:Q16254 (hE2F4) PRO 11042701, 11157749


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K20 T20 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K28 R28 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S218 N218 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S244 I244 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]