iPTMnet Report for Q16236 (NFE2L2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16236 / NF2L2_HUMAN
Protein Name Nuclear factor erythroid 2-related factor 2
Gene Name Name: NFE2L2
Synonyms:NRF2;
Organism Homo sapiens (Human)

PRO ID PR:Q16236
DAG View
PRO Name nuclear factor erythroid 2-related factor 2 (human)
Definition A nuclear factor erythroid 2-related factor 2 that is encoded in the genome of human.
Short Label hNFE2L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16236 (NFE2L2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation P05771 (PRKCB) , P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 28061443, 12700136, 25340789, ...30776542, 29253569, 32256951, 31817532, 33381502, 28202606, 32110852, 30662338, 28442712, 25907366, 29887940, 25505069, 15110384, 27680214, 29709474, 30703377, 22558124, 32863217, 26699938, 29230104, 28151479, 32811823, 33764436, 30069011, 22302998, 32708958, 31781326, 32121537, 25236495, 36458309, 12947090, 23434765, 19920073, 30533198, 25857617, 28974696, 32322337, 24203292, 31191797, 12198130, 23864927, 28638475, 27744118, 29874784, 33801351, 28604588, 30037352
K44 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
T80 Phosphorylation RLIMS-P 22125611, 22904695
K110 Sumoylation PhosphoSitePlus
C119 Methylation IEDB 31844290
S215 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19668370, 23186163, 34918396, ...20068231
S234 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
S344 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 22751928
S347 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 22751928
S351 Phosphorylation PhosphoSitePlus   RLIMS-P 33875681, 28724916
S356 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
T395 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P 25909891
S408 Phosphorylation PhosphoSitePlus   RLIMS-P 19668370, 34918396
T425 Phosphorylation PhosphoSitePlus
S433 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P 25909891
R437 Methylation PhosphoSitePlus
K438 Acetylation PhosphoSitePlus
T439 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P 25909891
K443 Acetylation PhosphoSitePlus
K445 Acetylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
K462 Acetylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K472 Acetylation PhosphoSitePlus
K487 Acetylation PhosphoSitePlus
K506 Acetylation PhosphoSitePlus
K508 Acetylation PhosphoSitePlus
K516 Acetylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K518 Acetylation PhosphoSitePlus
K518 Sumoylation PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
K533 Acetylation PhosphoSitePlus
K536 Acetylation PhosphoSitePlus
K538 Acetylation PhosphoSitePlus
K541 Acetylation PhosphoSitePlus
K543 Acetylation PhosphoSitePlus
K548 Acetylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
K554 Acetylation PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
K555 Acetylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
T559 Phosphorylation PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
Y576 Phosphorylation P06241 (FYN) PhosphoSitePlus 21097520
S577 Phosphorylation PhosphoSitePlus   RLIMS-P 19668370, 34918396
K596 Acetylation PhosphoSitePlus   UniProt 21196497
K599 Acetylation PhosphoSitePlus   UniProt 21196497
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation Q05655 (PRKCD) HPRD 12198130
S215 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q16236 (NFE2L2) S40 Q14145 (KEAP1) unknown eFIP 12700136
Phosphorylation Q16236 (NFE2L2) S408 Q13526 (PIN1) unknown eFIP 34918396
Phosphorylation Q16236 (NFE2L2) S40 Q14145 (KEAP1) unknown eFIP 28604588
Phosphorylation Q16236 (NFE2L2) S40 Q14145 (KEAP1) unknown eFIP 22558124


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S40 N40 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K53 Q53 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K56 R56 Biomuta DOID:3571 / liver cancer [ cosmic ]
K68 N68 Biomuta DOID:1319 / brain cancer [ cosmic ]
T80 K80 Biomuta DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]
T80 I80 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T80 A80 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
T80 R80 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T80 P80 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S347 L347 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S374 R374 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S376 F376 Biomuta DOID:11615 / penile cancer [ cosmic ]
S408 L408 Biomuta DOID:4159 / skin cancer [ cosmic ]
T439 P439 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K506 N506 Biomuta DOID:1324 / lung cancer [ cosmic ]
K508 E508 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K533 Q533 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K538 T538 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K543 R543 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K574 N574 Biomuta DOID:1324 / lung cancer [ cosmic ]
S577 F577 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2021 / placenta cancer [ cosmic ]
K596 R596 Biomuta DOID:1324 / lung cancer [ cosmic ]