Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16204 / CCDC6_HUMAN
Protein Name Coiled-coil domain-containing protein 6
Gene Name Name: CCDC6
Synonyms:D10S170,TST1;
Organism Homo sapiens (Human)

PRO ID PR:Q16204
DAG View
PRO Name coiled-coil domain-containing protein 6 (human)
Definition A coiled-coil domain-containing protein 6 that is encoded in the genome of human.
Short Label hCCDC6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16204 (CCDC6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S46 Phosphorylation HPRD   PhosphoSitePlus 20068231
S52 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...16964243, 19664994, 19651622, 18669648, 19690332, 20068231, 17924679
T60 Phosphorylation PhosphoSitePlus
S65 Phosphorylation HPRD   PhosphoSitePlus 20068231
K71 Ubiquitination PhosphoSitePlus
K74 Sumoylation PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
T115 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
K118 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
Y134 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
T185 Phosphorylation HPRD 20068231
K188 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
S240 Phosphorylation O14757 (CHEK1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16964243, 18691976, 21406692, ...23186163, 18212344, 24275569, 19690332, 19413330, 18220336, 15144186, 19651622, 17287340, 17081983, 15302935, 19664995, 17322306, 18669648, 21851590, 20166139, 19415658, 20068231
S244 Phosphorylation O14757 (CHEK1) , P24941 (CDK2) , P27361 (MAPK3) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16964243, 19664994, 18691976, ...21406692, 23186163, 18212344, 24275569, 19690332, 19413330, 14712216, 18088087, 18220336, 18847512, 15144186, 19651622, 17287340, 17081983, 15302935, 19664995, 18669648, 21851590, 20166139, 19415658, 20068231
S249 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S254 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 19415658, ...17322306, 18669648, 19690332, 20068231
K266 Sumoylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
S284 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K286 Ubiquitination PhosphoSitePlus
Y290 Phosphorylation PhosphoSitePlus
S323 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19651622, 20068231
S325 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S327 Phosphorylation PhosphoSitePlus
S328 Phosphorylation HPRD   PhosphoSitePlus 17081983
Y336 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
T349 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S351 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18088087, 18220336
S352 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
Y356 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T357 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S359 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 25885523, 18669648
S361 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S362 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S363 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S367 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231, ...17693683
S371 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y372 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S374 Phosphorylation PhosphoSitePlus
T376 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T380 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T383 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
T386 Phosphorylation HPRD   PhosphoSitePlus 20068231
S391 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y392 Phosphorylation PhosphoSitePlus
Y393 Phosphorylation PhosphoSitePlus
S395 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S406 Phosphorylation PhosphoSitePlus
R411 Methylation PhosphoSitePlus
S413 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 25885523, 23186163, 20068231
R415 Methylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S419 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18088087, 20068231
K424 Sumoylation PhosphoSitePlus
T427 Phosphorylation PhosphoSitePlus   RLIMS-P 25885523
S431 Phosphorylation HPRD 20068231
T434 Phosphorylation Q13315 (ATM) PhosphoSitePlus   RLIMS-P   Signor 23108047
S472 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S52 A52 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S65 W65 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S113 G113 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K173 N173 Biomuta DOID:363 / uterine cancer [ tcga ]
S327 Y327 Biomuta DOID:3571 / liver cancer [ icgc ]
S351 Y351 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S359 Y359 Biomuta DOID:3070 / malignant glioma [ tcga ]
S359 F359 Biomuta DOID:3070 / malignant glioma [ tcga ]
T380 M380 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T383 A383 Biomuta DOID:363 / uterine cancer [ tcga ]
S395 F395 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R415 W415 Biomuta DOID:3070 / malignant glioma [ cosmic ]
T427 M427 Biomuta DOID:10534 / stomach cancer [ tcga ]
S472 F472 Biomuta DOID:363 / uterine cancer [ tcga ]