Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15911 / ZFHX3_HUMAN
Protein Name Zinc finger homeobox protein 3
Gene Name Name: ZFHX3
Synonyms:ATBF1,C16orf47;
Organism Homo sapiens (Human)

PRO ID PR:Q15911
DAG View
PRO Name zinc finger homeobox protein 3 (human)
Definition A zinc finger homeobox protein 3 that is encoded in the genome of human.
Short Label hZFHX3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15911 (ZFHX3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
S267 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
Y293 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S353 O-Glycosylation GlyGen 30059200, 29237092, 29351928
T354 O-Glycosylation GlyGen 30059200, 29237092, 29351928
T413 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus   UniProt 23186163
T428 Phosphorylation PhosphoSitePlus   UniProt 24275569
S529 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus   UniProt 20068231
S571 O-Glycosylation GlyGen 30059200, 29237092, 29351928
S571 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S574 O-Glycosylation GlyGen 30059200, 29237092, 29351928
S718 Phosphorylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus
T796 Phosphorylation PhosphoSitePlus
S1115 Phosphorylation PhosphoSitePlus
S1117 Phosphorylation PhosphoSitePlus
K1126 Ubiquitination PhosphoSitePlus
S1146 Phosphorylation PhosphoSitePlus
T1147 Phosphorylation PhosphoSitePlus
S1180 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S1189 Phosphorylation PhosphoSitePlus
S1197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1201 Phosphorylation PhosphoSitePlus
S1204 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1247 Phosphorylation PhosphoSitePlus
S1394 Phosphorylation PhosphoSitePlus
S1580 Phosphorylation PhosphoSitePlus
T1588 Phosphorylation phospho.ELM 18669648
S1589 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1590 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1721 Phosphorylation PhosphoSitePlus
K1879 Ubiquitination PhosphoSitePlus
S1927 Phosphorylation PhosphoSitePlus
S1930 Phosphorylation PhosphoSitePlus
S1938 Phosphorylation PhosphoSitePlus
T1945 Phosphorylation PhosphoSitePlus
K2013 Ubiquitination PhosphoSitePlus
S2169 Phosphorylation PhosphoSitePlus
S2182 Phosphorylation PhosphoSitePlus
S2207 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y2209 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T2217 Phosphorylation PhosphoSitePlus
S2218 Phosphorylation PhosphoSitePlus
S2226 Phosphorylation PhosphoSitePlus
S2230 Phosphorylation PhosphoSitePlus
S2437 Phosphorylation PhosphoSitePlus
T2443 Phosphorylation PhosphoSitePlus
S2623 Phosphorylation PhosphoSitePlus
S2625 Phosphorylation PhosphoSitePlus
S2631 Phosphorylation PhosphoSitePlus
T2633 Phosphorylation PhosphoSitePlus
T2724 Phosphorylation PhosphoSitePlus
S2786 Phosphorylation PhosphoSitePlus
S2795 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2801 Phosphorylation PhosphoSitePlus
S2804 Phosphorylation PhosphoSitePlus
K2806 Sumoylation PhosphoSitePlus
T2865 Phosphorylation PhosphoSitePlus
S2867 Phosphorylation PhosphoSitePlus
S2868 Phosphorylation PhosphoSitePlus
T2876 Phosphorylation PhosphoSitePlus
S2896 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2900 Phosphorylation PhosphoSitePlus
T2954 Phosphorylation PhosphoSitePlus
S3007 Phosphorylation PhosphoSitePlus
S3018 Phosphorylation PhosphoSitePlus
K3053 Ubiquitination PhosphoSitePlus
K3064 Ubiquitination PhosphoSitePlus
T3401 Phosphorylation PhosphoSitePlus
S3409 Phosphorylation PhosphoSitePlus
K3416 Acetylation PhosphoSitePlus
S3418 Phosphorylation PhosphoSitePlus
K3420 Acetylation PhosphoSitePlus
S3432 Phosphorylation PhosphoSitePlus   UniProt 23186163
S3446 Phosphorylation PhosphoSitePlus
K3447 Ubiquitination PhosphoSitePlus
S3448 Phosphorylation PhosphoSitePlus
K3460 Ubiquitination PhosphoSitePlus
S3672 Phosphorylation PhosphoSitePlus
S3677 O-Glycosylation GlyGen 30059200, 29237092, 29351928
S3677 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S267 Phosphorylation HPRD 18088087
S425 Phosphorylation HPRD 19413330
S426 Phosphorylation HPRD 20068231
S526 Phosphorylation HPRD 20068231
S529 Phosphorylation HPRD 20068231
S533 Phosphorylation HPRD 20068231
S571 Phosphorylation HPRD 17081983, 20068231
S1180 Phosphorylation HPRD 17525332
S1197 Phosphorylation HPRD 18669648, 20068231
S1201 Phosphorylation HPRD 20068231
S1204 Phosphorylation HPRD 18669648, 20068231
S1208 Phosphorylation HPRD 20068231
S1247 Phosphorylation HPRD 20068231
T1588 Phosphorylation HPRD 18669648, 20068231
S1589 Phosphorylation HPRD 18669648
S1590 Phosphorylation HPRD 18669648, 17081983, 20068231
S2169 Phosphorylation HPRD 20068231
S2207 Phosphorylation HPRD 18669648, 20068231
Y2209 Phosphorylation HPRD 18669648
S2437 Phosphorylation HPRD 20068231
S2623 Phosphorylation HPRD 18452278
S2625 Phosphorylation HPRD 18452278
S3409 Phosphorylation HPRD 18452278
S3418 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y293 * Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S526 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S529 T529 Biomuta DOID:1324 / lung cancer [ cosmic ]
S529 R529 Biomuta DOID:3571 / liver cancer [ icgc ]
S574 T574 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S574 N574 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1146 C1146 Biomuta DOID:1324 / lung cancer [ tcga ]
S1189 Y1189 Biomuta DOID:363 / uterine cancer [ tcga ]
S1204 Y1204 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1208 L1208 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ tcga ] DOID:3070 / malignant glioma [ tcga ]
S1589 R1589 Biomuta DOID:3571 / liver cancer [ icgc ]
K1879 N1879 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S2169 F2169 Biomuta DOID:1909 / melanoma [ icgc, tcga ] DOID:1115 / sarcoma [ tcga ]
S2218 G2218 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S2625 R2625 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S2631 R2631 Biomuta DOID:1612 / breast cancer [ icgc ]
T2633 K2633 Biomuta DOID:3571 / liver cancer [ icgc ]
T2724 I2724 Biomuta DOID:3070 / malignant glioma [ tcga ]
S2804 C2804 Biomuta DOID:1324 / lung cancer [ tcga ]
S3418 Y3418 Biomuta DOID:3571 / liver cancer [ icgc ]
S3432 T3432 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]