iPTMnet Report for Q15858 (SCN9A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15858 / SCN9A_HUMAN
Protein Name Sodium channel protein type 9 subunit alpha
Gene Name Name: SCN9A
Synonyms:NENA;
Organism Homo sapiens (Human)

PRO ID PR:Q15858
DAG View
PRO Name sodium channel protein type 9 subunit alpha (human)
Definition A sodium channel protein type 9 subunit alpha that is encoded in the genome of human.
Short Label hSCN9A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15858 (SCN9A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K36 Ubiquitination PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
N283 N-Glycosylation GlyGen   UniProt 30765606
S453 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
K483 Acetylation PhosphoSitePlus
K494 Acetylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
K1034 Acetylation PhosphoSitePlus
S1164 Phosphorylation PhosphoSitePlus
T1234 Phosphorylation PhosphoSitePlus
N1352 N-Glycosylation GlyGen   UniProt 30765606
N1366 N-Glycosylation GlyGen   UniProt 30765606
N1375 N-Glycosylation GlyGen   UniProt 30765606
Y1413 Phosphorylation PhosphoSitePlus
S1418 Phosphorylation PhosphoSitePlus
K1480 Acetylation PhosphoSitePlus
Y1481 Phosphorylation PhosphoSitePlus
Y1482 Phosphorylation PhosphoSitePlus
S1490 Phosphorylation UniProt 25240195
Y1658 Phosphorylation PhosphoSitePlus
Y1668 Phosphorylation PhosphoSitePlus
S1873 Phosphorylation PhosphoSitePlus
Y1877 Phosphorylation PhosphoSitePlus
T1881 Phosphorylation PhosphoSitePlus
T1882 Phosphorylation PhosphoSitePlus
T1883 Phosphorylation PhosphoSitePlus
S1950 Phosphorylation PhosphoSitePlus
K1981 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S635 Phosphorylation PhosphoSitePlus
I848 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K36 Q36 Biomuta DOID:3565 / meningioma [ cosmic ]
N283 S283 Biomuta DOID:1319 / brain cancer [ cosmic ]
K494 N494 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S530 Y530 Biomuta DOID:1324 / lung cancer [ cosmic ]
S530 F530 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S542 F542 Biomuta DOID:4159 / skin cancer [ cosmic ]
S635 T635 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S691 I691 Biomuta DOID:1324 / lung cancer [ cosmic ]
S691 V691 Biomuta DOID:1324 / lung cancer [ cosmic ]
S691 G691 Biomuta DOID:1324 / lung cancer [ cosmic ]
I848 T848 Biomuta [ cosmic ]
N1352 S1352 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N1352 Y1352 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1418 Y1418 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y1668 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T1882 N1882 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1950 L1950 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K1981 N1981 Biomuta DOID:10534 / stomach cancer [ cosmic ]