iPTMnet Report for Q15833 (STXBP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15833 / STXB2_HUMAN
Protein Name Syntaxin-binding protein 2
Gene Name Name: STXBP2
Synonyms:UNC18B;
Organism Homo sapiens (Human)

PRO ID PR:Q15833
DAG View
PRO Name syntaxin-binding protein 2 (human)
Definition A syntaxin-binding protein 2 that is encoded in the genome of human.
Short Label hSTXBP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15833 (STXBP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Methylation PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
T304 O-Glycosylation GlyGen 30379171, 34019948
K320 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
R490 Methylation PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
R529 Methylation PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
T572 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 17716669
T572 Phosphorylation Q00535 (CDK5) phospho.ELM   Signor 17716669
K581 Ubiquitination PhosphoSitePlus
K585 Acetylation PhosphoSitePlus
K586 Acetylation PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S218 Phosphorylation HPRD 18452278
T226 Phosphorylation HPRD 18452278


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13277 (STX3) T14 Q15833 (STXBP2) inhibited_association eFIP 26936588


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S70 G70 Biomuta DOID:363 / uterine cancer [ icgc ]
K193 N193 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K320 N320 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
K332 R332 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y336 C336 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S360 L360 Biomuta DOID:4159 / skin cancer [ cosmic ]
R490 W490 Biomuta DOID:1324 / lung cancer [ cosmic ]
R529 P529 Biomuta DOID:184 / bone cancer [ cosmic ]