iPTMnet Report for Q15831 (STK11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15831 / STK11_HUMAN
Protein Name Serine/threonine-protein kinase STK11 precursor
Gene Name Name: STK11
Synonyms:LKB1,PJS;
Organism Homo sapiens (Human)

PRO ID PR:Q15831
DAG View
PRO Name serine/threonine-protein kinase STK11 (human)
Definition A serine/threonine-protein kinase STK11 that is encoded in the genome of human.
Short Label hSTK11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15831 (STK11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 11853558, 23186163
T32 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation P06239 (LCK) neXtProt   PhosphoSitePlus 21487392
K44 Acetylation PhosphoSitePlus   UniProt 18687677
K48 Acetylation PhosphoSitePlus   UniProt 18687677
K64 Acetylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus   UniProt 18687677
K97 Acetylation PhosphoSitePlus   UniProt 18687677
K178 Sumoylation PhosphoSitePlus
T185 Phosphorylation Q15831 (STK11) PhosphoSitePlus   Signor 12805220
T189 Phosphorylation Q15831 (STK11) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11853558, 25005758, 11430832
S240 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation P06239 (LCK) , P06241 (FYN) neXtProt 21487392, 20142099
K296 Acetylation PhosphoSitePlus   UniProt 18687677
S307 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus   RLIMS-P   Signor 19414597, 23577667
K311 Acetylation PhosphoSitePlus   UniProt 18687677
S325 Phosphorylation RLIMS-P 11853558
S334 Phosphorylation PhosphoSitePlus   RLIMS-P 34193159
T336 Phosphorylation Q15831 (STK11) PhosphoSitePlus   RLIMS-P   Signor   UniProt 28708087, 12552571, 11853558, ...22575644, 12805220
Y362 Phosphorylation P06241 (FYN) , P06239 (LCK) neXtProt 21487392, 20142099
T363 Phosphorylation Q15831 (STK11) , P78527 (PRKDC) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27705915, 12234250, 12805220
T367 Phosphorylation Q13315 (ATM) Signor 12234250
Q399 Phosphorylation UniProt 23612973
S401 Phosphorylation PhosphoSitePlus   UniProt 23186163
T402 Phosphorylation Q15831 (STK11) PhosphoSitePlus   Signor 12805220
S404 Phosphorylation PhosphoSitePlus
K416 Acetylation PhosphoSitePlus   UniProt 18687677
K423 Acetylation PhosphoSitePlus   UniProt 18687677
S428 Phosphorylation P28482 (MAPK1) , Q9UK32 (RPS6KA6) , O75582 (RPS6KA5) , P27361 (MAPK3) , Q15831 (STK11) , Q15418 (RPS6KA1) , Q05513 (PRKCZ) , P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33219302, 10642527, 18250273, ...23577667, 22848421, 26893937, 28903364, 26068970, 27226623, 27705915, 29914450, 16407220, 31554794, 27494711, 23592276, 30833748, 19414597, 11297520, 25384047, 18321849, 17875968, 18854309, 25846811
K431 Acetylation PhosphoSitePlus   UniProt 18687677
Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation HPRD 11853558, 20058876
T32 Phosphorylation HPRD 19664994
T189 Phosphorylation Q15831 (STK11) HPRD 11668633
S325 Phosphorylation HPRD 11853558
T336 Phosphorylation HPRD 11853558
T363 Phosphorylation Q13315 (ATM) HPRD 11853558, 12234250
S428 Phosphorylation O75582 (RPS6KA5) , P23443 (RPS6KB1) , P51812 (RPS6KA3) , P17612 (PRKACA) HPRD 11853558, 11297520
Site PTM Type PTM Enzyme Score Source PMID
S399 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus 23612973


Q15831 (STK11) as PTM Enzyme



Substrate Site Score Source PMID
O60285 (NUAK1) T211 PhosphoSitePlus   Signor 19927127, 14976552
P04637 (TP53) S15 neXtProt   PhosphoSitePlus   Signor 17108107, 11430832
P04637 (TP53) S392 neXtProt   PhosphoSitePlus   Signor 17108107, 11430832
P27448 (MARK3) T211 PhosphoSitePlus   Signor 12879020, 14976552
P27448 (MARK3) S215 PhosphoSitePlus   Signor 12879020, 14976552
P43268 (ETV4) S396 neXtProt 16912160
P49841 (GSK3B) S9 neXtProt 20592207
P54646 (PRKAA2) T172 neXtProt   RLIMS-P+   Signor 18693249, 26489410, 14614828, ...14976552, 12764152
P54646 (PRKAA2) T485 neXtProt 12764152
P57059 (SIK1) T182 PhosphoSitePlus   Signor 18946175, 14976552
P60484 (PTEN) S380 neXtProt   PhosphoSitePlus   Signor 18321849, 21779440
P60484 (PTEN) T382 neXtProt   PhosphoSitePlus   Signor 18321849, 21779440
P60484 (PTEN) T383 neXtProt   PhosphoSitePlus   Signor 18321849
P60484 (PTEN) S385 HPRD   Signor 15987703
Q13131 (PRKAA1) T183 PhosphoSitePlus 18303014, 14985505, 14511394, ...25874865, 16407220, 14614828, 18854318
Q13153 (PAK1) T109 PhosphoSitePlus   Signor 20400510
Q13485 (SMAD4) T77 PhosphoSitePlus 20974850
Q14680 (MELK) T167 PhosphoSitePlus   Signor 16216881, 14976552
Q15831 (STK11) T185 PhosphoSitePlus   Signor 12805220
Q15831 (STK11) T189 HPRD   PhosphoSitePlus   Signor   UniProt 11668633, 11430832
Q15831 (STK11) T336 PhosphoSitePlus   Signor   UniProt 12805220
Q15831 (STK11) T363 PhosphoSitePlus   Signor   UniProt 12805220
Q15831 (STK11) T402 PhosphoSitePlus   Signor 12805220
Q15831 (STK11) S428 PhosphoSitePlus   UniProt 18854309, 18321849
Q7KZI7 (MARK2) T208 neXtProt   PhosphoSitePlus   Signor 17573348, 14976552
Q7RTN6-5 (STRADA) T271 HPRD 12805220
Q7RTN6-3 (STRADA) T292 HPRD 12805220
Q7RTN6 (STRADA) T329 HPRD   PhosphoSitePlus   Signor 12805220
Q7RTN6-5 (STRADA) T361 HPRD 12805220
Q7RTN6-3 (STRADA) T382 HPRD 12805220
Q7RTN6-1 (STRADA) T419 HPRD   PhosphoSitePlus   Signor 12805220
Q8IWQ3 (BRSK2) T174 PhosphoSitePlus   Signor 14976552
Q8TDC3 (BRSK1) T189 PhosphoSitePlus   Signor 22020259, 14976552
Q8TDC3-2 (BRSK1) T205 PhosphoSitePlus 19958286, 14976552
Q96L34 (MARK4) T214 PhosphoSitePlus   Signor 14976552
Q9H093 (NUAK2) T208 PhosphoSitePlus   Signor 14976552
Q9H0K1 (SIK2) T175 PhosphoSitePlus   Signor 14976552
Q9NRH2-1 (SNRK) T173 HPRD   PhosphoSitePlus   Signor 15733851
Q9P0L2 (MARK1) T215 HPRD   PhosphoSitePlus   Signor 18691976, 17573348, 14976552, ...14517247
Q9P0L2-1 (MARK1) S219 HPRD 18691976, 14976552
Q9Y2K2 (SIK3) T221 Signor 14976552


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15831 (STK11) S428 Q13131 (PRKAA1) unknown eFIP 16407220