iPTMnet Report for Q15811 (ITSN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15811 / ITSN1_HUMAN
Protein Name Intersectin-1
Gene Name Name: ITSN1
Synonyms:ITSN;
Organism Homo sapiens (Human)

PRO ID PR:Q15811
DAG View
PRO Name intersectin-1 (human)
Definition An intersectin-1 that is encoded in the genome of human.
Short Label hITSN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15811 (ITSN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S188 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus   UniProt 23186163
S220 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S313 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S315 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S318 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K472 Acetylation PhosphoSitePlus
K475 Acetylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K495 Acetylation PhosphoSitePlus
K545 Acetylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
K658 Ubiquitination PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
K704 Ubiquitination PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
T832 Phosphorylation PhosphoSitePlus
T839 Phosphorylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
T861 Phosphorylation PhosphoSitePlus
T897 Phosphorylation PhosphoSitePlus
T899 Phosphorylation PhosphoSitePlus
S901 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S902 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S904 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935, ...24275569
Y922 Phosphorylation PhosphoSitePlus
S970 Phosphorylation PhosphoSitePlus
S976 Phosphorylation PhosphoSitePlus
T977 Phosphorylation PhosphoSitePlus
S978 Phosphorylation PhosphoSitePlus
S981 Phosphorylation PhosphoSitePlus
S983 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
S986 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S989 Phosphorylation PhosphoSitePlus
S995 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y1132 Phosphorylation PhosphoSitePlus
S1137 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1144 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y1208 Phosphorylation PhosphoSitePlus
K1303 Ubiquitination PhosphoSitePlus
T1383 Phosphorylation PhosphoSitePlus
T1501 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation HPRD 18767875
S313 Phosphorylation HPRD 20166139, 18669648, 20068231
S315 Phosphorylation HPRD 19413330, 20166139, 18669648, ...15345747
S559 Phosphorylation HPRD 17081983, 20068231
S624 Phosphorylation HPRD 20068231
S687 Phosphorylation HPRD 20068231
S891 Phosphorylation HPRD 20068231
T897 Phosphorylation HPRD 20068231
S901 Phosphorylation HPRD 18669648
S902 Phosphorylation HPRD 18669648, 15345747, 19664995, ...20068231, 18452278
S904 Phosphorylation HPRD 19413330, 20058876, 16964243, ...19664994, 15302935, 19664995, 18452278, 18669648, 20166139, 20068231
S976 Phosphorylation HPRD 20068231
S978 Phosphorylation HPRD 19413330
S983 Phosphorylation HPRD 20068231
S986 Phosphorylation HPRD 19413330, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation HPRD 18767875
S313 Phosphorylation HPRD 20166139, 18669648, 20068231
S315 Phosphorylation HPRD 19413330, 20166139, 18669648, ...15345747
S559 Phosphorylation HPRD 17081983, 20068231
S624 Phosphorylation HPRD 20068231
S687 Phosphorylation HPRD 20068231
S891 Phosphorylation HPRD 20068231
T897 Phosphorylation HPRD 20068231
S901 Phosphorylation HPRD 18669648
S902 Phosphorylation HPRD 18669648, 15345747, 19664995, ...20068231, 18452278
S904 Phosphorylation HPRD 19413330, 20058876, 16964243, ...19664994, 15302935, 19664995, 18452278, 18669648, 20166139, 20068231
S976 Phosphorylation HPRD 20068231
S978 Phosphorylation HPRD 19413330
S983 Phosphorylation HPRD 20068231
S986 Phosphorylation HPRD 19413330, 18669648
Site PTM Type PTM Enzyme Score Source PMID
K973 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S79 F79 Biomuta DOID:4159 / skin cancer [ cosmic ]
S188 C188 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S188 Y188 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S624 F624 Biomuta DOID:4159 / skin cancer [ cosmic ]
S687 I687 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S735 F735 Biomuta DOID:4159 / skin cancer [ cosmic ]
S840 C840 Biomuta DOID:1324 / lung cancer [ cosmic ]
T861 M861 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T897 M897 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S901 F901 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S904 Y904 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S970 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S976 A976 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S978 I978 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S981 A981 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S986 N986 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid cancer [ icgc, icgc ] DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic, cosmic ]
S1137 N1137 Biomuta DOID:363 / uterine cancer [ icgc ]