iPTMnet Report for Q15797 (SMAD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15797 / SMAD1_HUMAN
Protein Name Mothers against decapentaplegic homolog 1
Gene Name Name: SMAD1
Synonyms:BSP1,MADH1,MADR1;
Organism Homo sapiens (Human)

PRO ID PR:Q15797
DAG View
PRO Name mothers against decapentaplegic homolog 1 (human)
Definition A smad1 that is encoded in the genome of human.
Short Label hSMAD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15797 (SMAD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S11 Phosphorylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
K116 Sumoylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K118 Sumoylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
S187 Phosphorylation P50750 (CDK9) , P49336 (CDK8) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9335504, 19914161, 19914168
S195 Phosphorylation P49336 (CDK8) , P28482 (MAPK1) , P50750 (CDK9) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9335504, 19914161, 19914168
T202 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 17289590
S206 Phosphorylation P50750 (CDK9) , P50613 (CDK7) , P28482 (MAPK1) , P49336 (CDK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 9335504, 30674353, 19914168, ...29986870, 19914161, 24664641, 18436795, 17289590
S210 Phosphorylation RLIMS-P 27713415
S214 Phosphorylation P28482 (MAPK1) , P50750 (CDK9) , P49336 (CDK8) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9335504, 19914161, 19914168
S239 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 22588298
K269 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
T322 Phosphorylation Q8N4C8 (MINK1) , Q9UKE5 (TNIK) neXtProt   PhosphoSitePlus   UniProt 21690388
K418 Ubiquitination PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
S462 Phosphorylation O00238 (BMPR1B) phospho.ELM   PhosphoSitePlus   Signor 9335504, 9748228, 9136927, ...10085121
S463 Phosphorylation Q05655 (PRKCD) , O00238 (BMPR1B) , P36894 (BMPR1A) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9335504, 30674353, 9136927, ...9748228, 20927330, 28542453, 11779505, 10085121, 30854241
S465 Phosphorylation O00238 (BMPR1B) , Q05655 (PRKCD) , P36894 (BMPR1A) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9335504, 30674353, 9136927, ...9748228, 20927330, 28542453, 11779505, 10085121, 30854241
Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO 12857866
T10 Phosphorylation HPRD 20068231
S195 Phosphorylation P28482 (MAPK1) HPRD 9335504
S206 Phosphorylation P28482 (MAPK1) HPRD 9335504
S214 Phosphorylation P28482 (MAPK1) HPRD 9335504
S462 Phosphorylation Q04771 (ACVR1) , P36897 (TGFBR1) HPRD 9748228, 9136927, 10085121
S463 Phosphorylation P36897 (TGFBR1) , Q04771 (ACVR1) HPRD   PRO 9136927, 9748228, 19651622, ...12857866, 10085121
S465 Phosphorylation P36897 (TGFBR1) , Q04771 (ACVR1) HPRD   PRO 9136927, 9748228, 19651622, ...12857866, 10085121


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049280 (hSMAD1/UbiqLys+) ub PRO
PR:000050147 (hSMAD1/Phos:1) pS463,pS465 PRO
PR:000026334 (hSMAD1/iso:1/Phos:1) pS463,pS465 PRO
PR:000036553 (hSMAD1/iso:1/PhosUbiq:1) ub PRO 12857866
PR:000036553 (hSMAD1/iso:1/PhosUbiq:1) pS463,pS465 PRO 12857866


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000026334 (hSMAD1/iso:1/Phos:1) Interaction PR:Q13485 (hSMAD4) PRO 9136927
PR:O43541-1 (hSMAD6/iso:A) Interaction PR:000026334 (hSMAD1/iso:1/Phos:1) PRO 9436979
PR:Q15797-1 (hSMAD1/iso:1) Interaction PR:Q7Z3T8 (hZFYVE16) PRO 17356069


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S144 G144 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y146 C146 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T202 A202 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S315 F315 Biomuta DOID:4159 / skin cancer [ cosmic ]
S465 F465 Biomuta DOID:363 / uterine cancer [ icgc ]