iPTMnet Report for Q15796 (SMAD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15796 / SMAD2_HUMAN
Protein Name Mothers against decapentaplegic homolog 2
Gene Name Name: SMAD2
Synonyms:MADH2,MADR2;
Organism Homo sapiens (Human)

PRO ID PR:Q15796
DAG View
PRO Name mothers against decapentaplegic homolog 2 (human)
Definition A smad2 that is encoded in the genome of human.
Short Label hSMAD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15796 (SMAD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S2 Acetylation UniProt 19413330, 22814378, 22223895, ...20068231
S2 Phosphorylation PhosphoSitePlus
S3 Phosphorylation RLIMS-P 30356176
T8 Phosphorylation P27361 (MAPK3) , P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 23186163, 17081983, ...12193595, 15241418, 10197981, 19201832, 30343527, 19115199, 20068231, 11027280
K13 Ubiquitination PhosphoSitePlus
K19 Acetylation PhosphoSitePlus   UniProt 17074756
K20 Acetylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K46 Sumoylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
K54 Acetylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
C81 Methylation IEDB 31844290
T98 Phosphorylation RLIMS-P 28912531
Y102 Phosphorylation PhosphoSitePlus
S110 Phosphorylation Q9UQM7 (CAMK2A) , Q9H4A3 (WNK1) neXtProt   PhosphoSitePlus   Signor 17392271, 11027280
S118 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
K156 Sumoylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
T197 Phosphorylation P25098 (GRK2) PhosphoSitePlus 16121194
T220 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12193595, 25316549, 10197981, ...30343527, 19115199, 11027280
S240 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus   RLIMS-P   Signor   UniProt 11879191, 11027280
S245 Phosphorylation P27361 (MAPK3) , Q14680 (MELK) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12193595, 23437179, 26194464, ...29259896, 23077590, 25316549, 30072727, 10197981, 26057631, 22880011, 20659902, 23831640, 18032924, 19115199, 11027280
S250 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18032924, 23437179, 26194464, ...29259896, 23077590, 25316549, 30072727, 10197981, 26057631, 22880011, 23831640, 29577978, 30343527, 12193595, 19115199, 33676893, 11027280
S255 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12193595, 23437179, 26194464, ...29259896, 18032924, 25316549, 30072727, 10197981, 26057631, 22880011, 23831640, 23077590, 30343527, 19115199, 11027280
S260 Phosphorylation Q9UQM7 (CAMK2A) , Q9H4A3 (WNK1) neXtProt   PhosphoSitePlus   Signor 17392271, 11027280
S317 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus   RLIMS-P 28400474
S417 Phosphorylation Q13177 (PAK2) PhosphoSitePlus 22393057
K420 Acetylation PhosphoSitePlus
S458 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S460 Phosphorylation PhosphoSitePlus   UniProt 20068231
S464 Phosphorylation P36897 (TGFBR1) , O00238 (BMPR1B) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 9346908, 9892009, 8980228, ...9136927
S465 Phosphorylation Q9H4A3 (WNK1) , P36897 (TGFBR1) , PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) , O00238 (BMPR1B) , O96013 (PAK4) , Q8NER5 (ACVR1C) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 30135653, 26057631, 22880011, ...9346966, 17392271, 9346908, 23478445, 31817988, 30072727, 16709598, 24759784, 20717921, 17099224, 33406242, 23934187, 12660320, 30805303, 18032924, 9136927, 8980228, 15134444, 9892009, 23937725
S467 Phosphorylation Q8NER5 (ACVR1C) , PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) , O00238 (BMPR1B) , P36897 (TGFBR1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 30135653, 26057631, 22880011, ...9346966, 9346908, 23934187, 31817988, 30072727, 16709598, 24759784, 20717921, 17099224, 33406242, 23478445, 23937725, 30805303, 18032924, 9136927, 8980228, 15134444, 9892009, 12660320
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
T8 Phosphorylation P27361 (MAPK3) , PR:000026189 (hMAPK3/iso:1/Phos:1) HPRD   PRO 19413330, 12193595, 18491316, ...18691976, 19651622, 20068231, 11027280
K19 Acetylation PRO 17074756
S110 Phosphorylation Q9UQM7 (CAMK2A) HPRD 11027280
T220 Phosphorylation PR:000026196 (MAP2K1/iso:1/Phos:1) , P28482 (MAPK1) , PR:000026189 (hMAPK3/iso:1/Phos:1) HPRD   PRO 12193595, 10197981
S240 Phosphorylation Q9UQM7 (CAMK2A) , PR:000003197 (calcium/calmodulin-dependent protein kinase type II chain) HPRD   PRO 11027280
S245 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) , P28482 (MAPK1) , PR:000026196 (MAP2K1/iso:1/Phos:1) HPRD   PRO 12193595, 10197981
S250 Phosphorylation P28482 (MAPK1) , PR:000026196 (MAP2K1/iso:1/Phos:1) , PR:000026189 (hMAPK3/iso:1/Phos:1) HPRD   PRO 12193595, 10197981
S255 Phosphorylation PR:000026189 (hMAPK3/iso:1/Phos:1) , PR:000026196 (MAP2K1/iso:1/Phos:1) PRO 12193595, 10197981
S260 Phosphorylation Q9UQM7 (CAMK2A) HPRD 11027280
S458 Phosphorylation HPRD 18691976, 18669648, 19415658, ...20068231
S460 Phosphorylation HPRD 20068231
S464 Phosphorylation P36897 (TGFBR1) , P36896 (ACVR1B) HPRD 9346908, 9892009
S465 Phosphorylation PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) , P36896 (ACVR1B) , P36897 (TGFBR1) HPRD   PRO 17074756, 12193595, 8980228, ...9346966, 9346908, 9892009, 11027280
S467 Phosphorylation P36896 (ACVR1B) , PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) , P36897 (TGFBR1) HPRD   PRO 17074756, 12193595, 8980228, ...9346966, 9346908, 9892009, 11027280
Site PTM Type PTM Enzyme Score Source PMID
K19 Acetylation PRO 17074756
S435 Phosphorylation PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) PRO 17074756
S437 Phosphorylation PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) PRO 17074756


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049282 (hSMAD2/InitMet-/Phos:1) pS465,pS467 PRO
PR:000049283 (hSMAD2/InitMet-/Phos:5) pT220,pS465,pS467 PRO
PR:000049284 (hSMAD2/InitMet-/UbiqLys+) ub PRO
PR:000050145 (hSMAD2/Phos:1) pS465,pS467 PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) PRO 8980228, 9346966
PR:000025934 (hSMAD2/iso:Long/Phos:1) pS465,pS467 PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) PRO 8980228, 9346966
PR:000025935 (hSMAD2/iso:Long/Phos:2) pS465,pS467 PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) PRO 12193595
PR:000025935 (hSMAD2/iso:Long/Phos:2) pT8,pT220,pS245,pS250,pS255 PR:000026189 (hMAPK3/iso:1/Phos:1) PRO 12193595
PR:000025936 (hSMAD2/iso:Long/Phos:3) pS240 PR:000003197 (calcium/calmodulin-dependent protein kinase type II chain) PRO 11027280
PR:000025936 (hSMAD2/iso:Long/Phos:3) pS465,pS467 PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) PRO 11027280
PR:000025937 (hSMAD2/iso:Long/Phos:4) pT220,pS245,pS250,pS255 PR:000026196 (MAP2K1/iso:1/Phos:1) PRO 10197981
PR:000036554 (hSMAD2/iso:Long/AcPhos:1) acK19 PRO 17074756
PR:000036554 (hSMAD2/iso:Long/AcPhos:1) pS465,pS467 PRO 17074756
PR:000025938 (hSMAD2/iso:Short/Phos:1) pS435,pS437 PR:000025963 (h(TGFBR2/iso:1/SigPep-/Phos:1)*2) PRO
PR:000036556 (hSMAD2/iso:Short/AcPhos:1) acK19 PRO 17074756
PR:000036556 (hSMAD2/iso:Short/AcPhos:1) pS435,pS437 PRO 17074756


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43683 (BUB1) S318 Q15796 (SMAD2) unknown eFIP 32143140
Phosphorylation Q15796 (SMAD2) S465 Q13485 (SMAD4) unknown eFIP 9346908


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025934 (hSMAD2/iso:Long/Phos:1) Interaction PR:Q13485 (hSMAD4) PRO 9311995
PR:000025935 (hSMAD2/iso:Long/Phos:2) Interaction PR:Q13485 (hSMAD4) PRO 12193595
PR:000025936 (hSMAD2/iso:Long/Phos:3) Interaction PR:Q13485 (hSMAD4) PRO 11027280
PR:000045371 (hSMAD2/iso:Long/UnPhos:1) Interaction PRO 8980228
PR:O95405-1 (hZFYVE9/iso:1) Interaction PR:000025960 (hSMAD2/iso:[Long/Short]/UnPhos:1) PRO 11877415, 9865696


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 * Biomuta [ cosmic ]
S2 P2 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2 L2 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S3 F3 Biomuta DOID:4159 / skin cancer [ cosmic ]
K20 N20 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S21 L21 Biomuta DOID:4159 / skin cancer [ cosmic ]
K54 T54 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K63 Q63 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S118 F118 Biomuta [ cosmic ]
Y128 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K156 E156 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K157 T157 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y165 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y165 F165 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y165 D165 Biomuta DOID:4159 / skin cancer [ cosmic ]
T220 A220 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T220 M220 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S240 R240 Biomuta DOID:1612 / breast cancer [ cosmic ]
S245 C245 Biomuta DOID:1324 / lung cancer [ cosmic ]
S250 F250 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S255 F255 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S417 R417 Biomuta DOID:363 / uterine cancer [ icgc ]
S417 N417 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K420 Q420 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S435 N435 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S435 I435 Biomuta DOID:1725 / peritoneum cancer [ cosmic ]
S435 R435 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1725 / peritoneum cancer [ cosmic ]
S437 L437 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1725 / peritoneum cancer [ cosmic ]
S437 T437 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S437 P437 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S460 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S464 L464 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1725 / peritoneum cancer [ cosmic ]
S464 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, tcga ] DOID:11054 / urinary bladder cancer [ cosmic ]
S465 N465 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S465 I465 Biomuta DOID:1725 / peritoneum cancer [ cosmic ]
S465 R465 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1725 / peritoneum cancer [ cosmic ]
S467 T467 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S467 P467 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S467 L467 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1725 / peritoneum cancer [ cosmic ]