iPTMnet Report for Q15788 (NCOA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15788 / NCOA1_HUMAN
Protein Name Nuclear receptor coactivator 1
Gene Name Name: NCOA1
Synonyms:BHLHE74,SRC1;
Organism Homo sapiens (Human)

PRO ID PR:Q15788
DAG View
PRO Name nuclear receptor coactivator 1 (human)
Definition A nuclear receptor coactivator 1 that is encoded in the genome of human.
Short Label hNCOA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15788 (NCOA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S22 Phosphorylation PhosphoSitePlus   UniProt 23186163
T26 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S103 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S192 Phosphorylation PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S372 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 10660621
S389 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
S395 Phosphorylation P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 10660621, 20068231
S423 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
S517 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 10660621
S558 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
S569 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 10660621
S582 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
K632 Acetylation PhosphoSitePlus
T638 O-Glycosylation GlyGen 28657654, 35254053
T639 O-Glycosylation GlyGen 28657654, 35254053
T640 O-Glycosylation GlyGen 28657654, 35254053
S659 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus   UniProt 23186163
K732 Sumoylation PhosphoSitePlus
K774 Sumoylation PhosphoSitePlus
T789 Phosphorylation PhosphoSitePlus
T841 O-Glycosylation GlyGen 28657654, 35254053
T844 O-Glycosylation GlyGen 28657654, 35254053
S853 Phosphorylation PhosphoSitePlus
S863 Phosphorylation IEDB   PhosphoSitePlus 30784271
K959 Ubiquitination PhosphoSitePlus
T979 Phosphorylation PhosphoSitePlus
S997 Phosphorylation PhosphoSitePlus
S1006 Phosphorylation PhosphoSitePlus
T1026 Phosphorylation PhosphoSitePlus
R1029 Methylation PhosphoSitePlus
S1033 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 10660621
R1041 Methylation PhosphoSitePlus
R1114 Methylation PhosphoSitePlus
R1131 Methylation PhosphoSitePlus
T1179 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10660621, 12163482
S1185 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10660621, 12163482
S1250 Phosphorylation PhosphoSitePlus
T1271 Phosphorylation PhosphoSitePlus
S1279 Phosphorylation PhosphoSitePlus
S1372 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1426 Phosphorylation PhosphoSitePlus   RLIMS-P 21550420
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
S22 Phosphorylation HPRD 19413330
S103 Phosphorylation HPRD 17525332
T209 Phosphorylation HPRD 20068231
S372 Phosphorylation HPRD 10660621
S395 Phosphorylation P28482 (MAPK1) HPRD 10660621, 20068231
S517 Phosphorylation HPRD 10660621
S565 Phosphorylation HPRD 18077418
S566 Phosphorylation HPRD 18077418
S569 Phosphorylation HPRD 18077418, 10660621
S582 Phosphorylation HPRD 18077418
S659 Phosphorylation HPRD 20068231
T661 Phosphorylation HPRD 20068231
T663 Phosphorylation HPRD 20068231
S664 Phosphorylation HPRD 20068231
S681 Phosphorylation HPRD 20068231
T684 Phosphorylation HPRD 20068231
S1033 Phosphorylation HPRD 10660621
T1179 Phosphorylation P28482 (MAPK1) HPRD 10660621, 12163482
S1185 Phosphorylation P28482 (MAPK1) HPRD 10660621, 12163482
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
S22 Phosphorylation HPRD 19413330
S103 Phosphorylation HPRD 17525332
T209 Phosphorylation HPRD 20068231
S372 Phosphorylation HPRD 10660621
S395 Phosphorylation P28482 (MAPK1) HPRD 10660621, 20068231
S517 Phosphorylation HPRD 10660621
S565 Phosphorylation HPRD 18077418
S566 Phosphorylation HPRD 18077418
S569 Phosphorylation HPRD 18077418, 10660621
S582 Phosphorylation HPRD 18077418
S659 Phosphorylation HPRD 20068231
T661 Phosphorylation HPRD 20068231
T663 Phosphorylation HPRD 20068231
S664 Phosphorylation HPRD 20068231
S681 Phosphorylation HPRD 20068231
T684 Phosphorylation HPRD 20068231
S1033 Phosphorylation HPRD 10660621
T1179 Phosphorylation P28482 (MAPK1) HPRD 10660621, 12163482
S1185 Phosphorylation P28482 (MAPK1) HPRD 10660621, 12163482
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
S22 Phosphorylation HPRD 19413330
S103 Phosphorylation HPRD 17525332
T209 Phosphorylation HPRD 20068231
S372 Phosphorylation HPRD 10660621
S395 Phosphorylation P28482 (MAPK1) HPRD 10660621, 20068231
S517 Phosphorylation HPRD 10660621
S565 Phosphorylation HPRD 18077418
S566 Phosphorylation HPRD 18077418
S569 Phosphorylation HPRD 18077418, 10660621
S582 Phosphorylation HPRD 18077418
S659 Phosphorylation HPRD 20068231
T661 Phosphorylation HPRD 20068231
T663 Phosphorylation HPRD 20068231
S664 Phosphorylation HPRD 20068231
S681 Phosphorylation HPRD 20068231
T684 Phosphorylation HPRD 20068231
S1033 Phosphorylation HPRD 10660621
T1179 Phosphorylation P28482 (MAPK1) HPRD 10660621, 12163482
S1185 Phosphorylation P28482 (MAPK1) HPRD 10660621, 12163482


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 L22 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S30 I30 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S308 A308 Biomuta DOID:4159 / skin cancer [ cosmic ]
S372 C372 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S517 T517 Biomuta DOID:363 / uterine cancer [ cosmic ]
S566 A566 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T663 A663 Biomuta DOID:263 / kidney cancer [ cosmic ]
S698 R698 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S863 F863 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K959 E959 Biomuta DOID:1324 / lung cancer [ cosmic ]
T979 M979 Biomuta [ cosmic, cosmic ] DOID:1612 / breast cancer [ cosmic, icgc, cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic, cosmic, icgc, cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc, cosmic, icgc ] DOID:1115 / sarcoma [ icgc, icgc ] DOID:11934 / head and neck cancer [ icgc, icgc ] DOID:8618 / oral cavity cancer [ cosmic, cosmic ]
R1029 Q1029 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R1029 G1029 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1033 L1033 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
R1114 W1114 Biomuta DOID:363 / uterine cancer [ icgc ]
R1114 Q1114 Biomuta DOID:4362 / cervical cancer [ icgc ]
R1114 L1114 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R1131 T1131 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]