Protein Information

Cytoscape View

UniProt AC / UniProt ID Q15759 / MK11_HUMAN
Protein Name Mitogen-activated protein kinase 11
Gene Name Name: MAPK11
Organism Homo sapiens (Human)

PRO ID PR:Q15759
DAG View
PRO Name mitogen-activated protein kinase 11 (human)
Definition A mitogen-activated protein kinase 11 that is encoded in the genome of human.
Short Label hMAPK11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q15759 (MAPK11) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S143 Phosphorylation PhosphoSitePlus
T180 Phosphorylation P52564 (MAP2K6) , Q15759 (MAPK11) neXtProt   PRO   PhosphoSitePlus   RLIMS-P+   UniProt 8846784, 26976637, 9790884, ...15356147
Y182 Phosphorylation P52564 (MAP2K6) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 18083107, 8846784, 9790884, ...15356147
T185 Phosphorylation PhosphoSitePlus
T241 Phosphorylation Q15759 (MAPK11) PhosphoSitePlus   RLIMS-P+ 26976637
S243 Phosphorylation PhosphoSitePlus
S261 Phosphorylation Q15759 (MAPK11) PhosphoSitePlus   RLIMS-P+ 26976637
S272 Phosphorylation PhosphoSitePlus
Y323 Phosphorylation RLIMS-P 19324872
S359 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y182 Phosphorylation HPRD 18083107
S243 Phosphorylation HPRD 19664994

Q15759 (MAPK11) as PTM Enzyme

Substrate Site Score Source PMID
O00418 (EEF2K) S396 HPRD   neXtProt   PhosphoSitePlus 12171600
O60381 (HBP1) S402 phospho.ELM   Signor 14612426
O75582 (RPS6KA5) S360 Signor 9687510
O75582 (RPS6KA5) T581 Signor 9687510
O75582 (RPS6KA5) T700 Signor 9687510
O75928 (PIAS2) S113 neXtProt   Signor 16713578
O75928 (PIAS2) S116 neXtProt   Signor 16713578
P00533 (EGFR) S1039 PhosphoSitePlus 19531499
P00533 (EGFR) T1041 PhosphoSitePlus 19531499
P04150 (NR3C1) S226 PhosphoSitePlus 22911818
P05787 (KRT8) S74 Signor 11788583
P10636-8 (MAPT) T50 neXtProt 15632108
P10636-8 (MAPT) T69 neXtProt 15632108
P10636-8 (MAPT) T153 neXtProt 15632108
P10636-8 (MAPT) S202 neXtProt 15632108
P10636-8 (MAPT) T205 neXtProt 15632108
P10636-8 (MAPT) S235 neXtProt 15632108
P10636-8 (MAPT) S404 neXtProt 15632108
P10636-8 (MAPT) S422 neXtProt 15632108
P13807 (GYS1) S645 neXtProt   PhosphoSitePlus 14680475
P13807 (GYS1) S653 neXtProt   PhosphoSitePlus 14680475
P13807 (GYS1) T721 neXtProt   PhosphoSitePlus 14680475
P13807 (GYS1) S727 neXtProt   PhosphoSitePlus 14680475
P15923 (TCF3) S139 Signor 15719023
P16949 (STMN1) S25 neXtProt 16110469
P17544 (ATF7) T51 PhosphoSitePlus 18950637
P30281 (CCND3) T283 neXtProt   PhosphoSitePlus 15326477
P30305 (CDC25B) S249 neXtProt   PhosphoSitePlus 16861915
P41235 (HNF4A) S167 phospho.ELM   PhosphoSitePlus 16351573
P42224 (STAT1) S727 neXtProt 14963018
Q01094 (E2F1) S403 neXtProt   PhosphoSitePlus 18794805
Q01094 (E2F1) T433 neXtProt   PhosphoSitePlus 18794805
Q01844 (EWSR1) T79 neXtProt   PhosphoSitePlus   Signor 19076070
Q02156 (PRKCE) S350 neXtProt   PhosphoSitePlus 18604201
Q14934 (NFATC4) S168 neXtProt 11997522
Q14934 (NFATC4) S170 neXtProt 11997522
Q15672 (TWIST1) S68 Signor 21502402
Q15759 (MAPK11) T180 RLIMS-P+ 26976637
Q15759 (MAPK11) T241 RLIMS-P+ 26976637
Q15759 (MAPK11) S261 RLIMS-P+ 26976637
Q8IW41 (MAPKAPK5) T182 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18669648, 9628874
Q8N122 (RPTOR) S771 neXtProt   PhosphoSitePlus   Signor 21757713
Q8N122 (RPTOR) S863 neXtProt   PhosphoSitePlus   Signor 21757713
Q92945 (KHSRP) T692 neXtProt 16364914


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048316 (hMAPK11/Phos:1) pT180,pY182 PRO 8846784

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S143 L143 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:2531 / hematologic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S243 R243 Biomuta DOID:3571 / liver cancer [ icgc ]