Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15751 / HERC1_HUMAN
Protein Name Probable E3 ubiquitin-protein ligase HERC1
Gene Name Name: HERC1
Organism Homo sapiens (Human)

PRO ID PR:Q15751
DAG View
PRO Name probable E3 ubiquitin-protein ligase HERC1 (human)
Definition A probable E3 ubiquitin-protein ligase HERC1 that is encoded in the genome of human.
Short Label hHERC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15751 (HERC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K58 Ubiquitination PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
T450 Phosphorylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
T555 Phosphorylation PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
K965 Ubiquitination PhosphoSitePlus
K969 Ubiquitination PhosphoSitePlus
Y1287 Phosphorylation PhosphoSitePlus
K1291 Ubiquitination PhosphoSitePlus
S1294 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y1297 Phosphorylation PhosphoSitePlus
K1311 Ubiquitination PhosphoSitePlus
T1318 Phosphorylation PhosphoSitePlus
S1328 Phosphorylation PhosphoSitePlus
S1333 Phosphorylation PhosphoSitePlus
S1342 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163
T1344 Phosphorylation PhosphoSitePlus
S1391 Phosphorylation PhosphoSitePlus
S1406 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1410 Phosphorylation PhosphoSitePlus
S1421 Phosphorylation PhosphoSitePlus
S1428 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T1429 Phosphorylation PhosphoSitePlus
S1491 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692
T1493 Phosphorylation PhosphoSitePlus
S1496 Phosphorylation PhosphoSitePlus
T1501 Phosphorylation PhosphoSitePlus
S1502 Phosphorylation PhosphoSitePlus
Y1505 Phosphorylation PhosphoSitePlus
S1510 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648
S1512 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18077418, 23186163, 18669648, ...24275569
S1514 Phosphorylation HPRD   PhosphoSitePlus 17081983
S1517 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18077418, 17525332, 18669648
S1521 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17525332, 23186163, 18077418, ...19651622, 18669648, 19690332
S1541 Phosphorylation PhosphoSitePlus
K1544 Ubiquitination PhosphoSitePlus
S1550 Phosphorylation PhosphoSitePlus
S1558 Phosphorylation PhosphoSitePlus
K1918 Ubiquitination PhosphoSitePlus
R1952 Methylation PhosphoSitePlus
K2007 Ubiquitination PhosphoSitePlus
K2014 Ubiquitination PhosphoSitePlus
K2017 Ubiquitination PhosphoSitePlus
S2093 Phosphorylation PhosphoSitePlus
Y2231 Phosphorylation PhosphoSitePlus
K2339 Ubiquitination PhosphoSitePlus
S2422 Phosphorylation PhosphoSitePlus   UniProt 23186163
K2431 Ubiquitination PhosphoSitePlus
T2442 Phosphorylation PhosphoSitePlus
K2450 Ubiquitination PhosphoSitePlus
S2451 Phosphorylation PhosphoSitePlus
T2454 Phosphorylation PhosphoSitePlus
K2458 Ubiquitination PhosphoSitePlus
K2485 Ubiquitination PhosphoSitePlus
Y2510 Phosphorylation PhosphoSitePlus
Y2528 Phosphorylation PhosphoSitePlus
S2545 Phosphorylation PhosphoSitePlus
K2612 Ubiquitination PhosphoSitePlus
S2679 Phosphorylation PhosphoSitePlus
T2701 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...18220336
S2705 Phosphorylation HPRD   PhosphoSitePlus 18669648
S2706 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
T2709 Phosphorylation HPRD   PhosphoSitePlus 18669648
S2710 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
S2720 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
S2723 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2726 Phosphorylation PhosphoSitePlus
S2738 Phosphorylation PhosphoSitePlus
S2745 Phosphorylation PhosphoSitePlus
T2746 Phosphorylation PhosphoSitePlus
S2747 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20068231
S2763 Phosphorylation PhosphoSitePlus
K2769 Ubiquitination PhosphoSitePlus
K2881 Ubiquitination PhosphoSitePlus
T2888 Phosphorylation PhosphoSitePlus
S3005 Phosphorylation PhosphoSitePlus
K3042 Ubiquitination PhosphoSitePlus
K3051 Ubiquitination PhosphoSitePlus
K3059 Ubiquitination PhosphoSitePlus
S3238 Phosphorylation PhosphoSitePlus
S3254 Phosphorylation PhosphoSitePlus
K3311 Ubiquitination PhosphoSitePlus
T3328 Phosphorylation PhosphoSitePlus
S3329 Phosphorylation PhosphoSitePlus
T3335 Phosphorylation PhosphoSitePlus
K3348 Ubiquitination PhosphoSitePlus
K3355 Ubiquitination PhosphoSitePlus
K3440 Ubiquitination PhosphoSitePlus
K3459 Ubiquitination PhosphoSitePlus
K3460 Ubiquitination PhosphoSitePlus
K3611 Ubiquitination PhosphoSitePlus
K3616 Ubiquitination PhosphoSitePlus
T3628 Phosphorylation HPRD   PhosphoSitePlus 17287340
S3631 Phosphorylation HPRD   PhosphoSitePlus 17287340
T3643 Phosphorylation HPRD   PhosphoSitePlus 17287340
K3837 Ubiquitination PhosphoSitePlus
K4232 Ubiquitination PhosphoSitePlus
S4393 Phosphorylation PhosphoSitePlus
S4459 Phosphorylation PhosphoSitePlus
K4462 Ubiquitination PhosphoSitePlus
K4468 Ubiquitination PhosphoSitePlus
K4487 Ubiquitination PhosphoSitePlus
K4499 Ubiquitination PhosphoSitePlus
S4672 Phosphorylation PhosphoSitePlus
T4676 Phosphorylation PhosphoSitePlus
S4678 Phosphorylation PhosphoSitePlus
T4786 Phosphorylation HPRD 17081983
S4790 Phosphorylation HPRD 17081983
K4797 Ubiquitination PhosphoSitePlus
S4857 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 18669648, 17081983, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T241 I241 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S260 L260 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K499 I499 Biomuta DOID:263 / kidney cancer [ cosmic ]
K965 N965 Biomuta DOID:363 / uterine cancer [ tcga ]
K969 T969 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y1287 C1287 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S1421 Y1421 Biomuta DOID:3571 / liver cancer [ icgc ]
T1429 K1429 Biomuta DOID:3571 / liver cancer [ icgc ]
T1493 N1493 Biomuta DOID:363 / uterine cancer [ tcga ]
T1493 P1493 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
Y1505 C1505 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1510 L1510 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T2442 A2442 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K2485 E2485 Biomuta DOID:1909 / melanoma [ cosmic ]
S2705 Y2705 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
S2706 * Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S2706 L2706 Biomuta DOID:363 / uterine cancer [ tcga ]
S2723 Y2723 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T2746 A2746 Biomuta DOID:363 / uterine cancer [ tcga ]
S3254 R3254 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S3329 F3329 Biomuta DOID:1324 / lung cancer [ tcga ]
T3335 K3335 Biomuta DOID:3571 / liver cancer [ icgc ]
T3335 I3335 Biomuta DOID:363 / uterine cancer [ cosmic ]
K3440 T3440 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K3616 N3616 Biomuta DOID:1324 / lung cancer [ tcga ]
T3643 A3643 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S4678 F4678 Biomuta DOID:1909 / melanoma [ icgc, tcga ]