iPTMnet Report for Q15750 (TAB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15750 / TAB1_HUMAN
Protein Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Gene Name Name: TAB1
Synonyms:MAP3K7IP1;
Organism Homo sapiens (Human)

PRO ID PR:Q15750
DAG View
PRO Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human)
Definition A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human.
Short Label hTAB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15750 (TAB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S11 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S46 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
S52 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
C62 Methylation IEDB 31844290
K150 Ubiquitination PhosphoSitePlus
S163 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
Y179 Phosphorylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S391 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
S395 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 32938750, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
S396 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
S399 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
T400 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
S401 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
T403 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
T406 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
S423 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
S423 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19393267, 14592977
T431 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19393267, 14592977
S438 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14592977, 18021073, 24275569, ...16845370
T442 Phosphorylation PhosphoSitePlus   UniProt 24275569
T450 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
S452 Phosphorylation O43318 (MAP3K7) , Q16539 (MAPK14) PhosphoSitePlus 22216226
S453 Phosphorylation O43318 (MAP3K7) , Q16539 (MAPK14) PhosphoSitePlus 22216226
S456 Phosphorylation Q16539 (MAPK14) , O43318 (MAP3K7) PhosphoSitePlus 22216226
S457 Phosphorylation Q16539 (MAPK14) , O43318 (MAP3K7) PhosphoSitePlus 22216226
S469 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus
Y488 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
T502 O-Glycosylation GlyGen 23301498, 36032089, 35138101, ...30620550, 31492838, 35289036, 20863279, 22661428, 29237092, 32510947, 28346405, 28686627, 34725712, 23103942, 22307082, 22311971, 32119511, 24256146, 30059200, 32574038, 28609614, 22365600, 33103664, 28604694, 29485866, 32092778, 29351928, 28657654, 33214551, 30379171, 35132862, 35254053, 27935279, 34019948, 34764280, 36240223, 18818698, 33709700
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K42 T42 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S163 L163 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K192 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K229 R229 Biomuta DOID:1319 / brain cancer [ cosmic ]
S339 I339 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S378 R378 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S438 R438 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S457 F457 Biomuta DOID:4159 / skin cancer [ cosmic ]
S469 L469 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y488 S488 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y488 C488 Biomuta DOID:9256 / colorectal cancer [ cosmic ]