Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15746 / MYLK_HUMAN
Protein Name Myosin light chain kinase, smooth muscle
Gene Name Name: MYLK
Synonyms:MLCK,MLCK1,MYLK1;
Organism Homo sapiens (Human)

PRO ID PR:Q15746
DAG View
PRO Name myosin light chain kinase, smooth muscle (human)
Definition A myosin light chain kinase, smooth muscle that is encoded in the genome of human.
Short Label hMYLK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15746 (MYLK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation phospho.ELM   RLIMS-P 15750850, 11346659, 11964068
S16 Phosphorylation phospho.ELM   PhosphoSitePlus 11964068
T88 Phosphorylation PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
Y231 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor   UniProt 20861316
S287 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus   UniProt 24275569
S324 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
Y464 Phosphorylation P00519 (ABL1) , P12931 (SRC) neXtProt   PhosphoSitePlus   Signor   UniProt 11113114, 20861316, 12408982
S469 Phosphorylation PhosphoSitePlus
Y471 Phosphorylation P12931 (SRC) neXtProt   PhosphoSitePlus   Signor   UniProt 11113114, 12408982
T488 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
Y556 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor   UniProt 20861316
K603 Methylation PhosphoSitePlus
K608 Acetylation PhosphoSitePlus   UniProt 19826488
Y611 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   UniProt 20861316
Y792 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   UniProt 20861316
S814 Phosphorylation RLIMS-P 7547920
S815 Phosphorylation RLIMS-P 7547920
S827 Phosphorylation PhosphoSitePlus
Y846 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor   UniProt 20861316
S848 Phosphorylation PhosphoSitePlus
T883 Phosphorylation PhosphoSitePlus
S911 Phosphorylation PhosphoSitePlus
S947 Phosphorylation PhosphoSitePlus
T978 Phosphorylation PhosphoSitePlus
K1042 Acetylation PhosphoSitePlus
S1093 Phosphorylation PhosphoSitePlus
K1101 Methylation PhosphoSitePlus
K1103 Methylation PhosphoSitePlus
K1113 Acetylation PhosphoSitePlus
S1151 Phosphorylation PhosphoSitePlus
S1208 Phosphorylation Q13177 (PAK2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus 10748018
S1209 Phosphorylation PhosphoSitePlus
T1230 Phosphorylation PhosphoSitePlus
Y1410 Phosphorylation PhosphoSitePlus
S1438 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 24275569, 18318008
Y1449 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   UniProt 20861316
K1496 Acetylation PhosphoSitePlus
Y1575 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   UniProt 20861316
S1617 Phosphorylation PhosphoSitePlus
T1624 Phosphorylation PhosphoSitePlus
Y1635 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   UniProt 20861316
K1744 Acetylation PhosphoSitePlus
K1747 Acetylation PhosphoSitePlus
T1748 Phosphorylation Q15746 (MYLK) neXtProt 7711037
S1759 Phosphorylation Q13177 (PAK2) neXtProt   PRO   PhosphoSitePlus 10748018
S1760 Phosphorylation Q15746 (MYLK) neXtProt   phospho.ELM   PhosphoSitePlus 10748018, 18088087, 7711037, ...2160950
S1768 Phosphorylation Q15746 (MYLK) neXtProt   PhosphoSitePlus 7711037
S1772 Phosphorylation Q13153 (PAK1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 15310280, 18088087, 24275569
S1773 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 15310280, 2160950, 11964068
T1774 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
S1776 Phosphorylation P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   UniProt 15310280, 18088087, 24275569, ...11964068
T1778 Phosphorylation PhosphoSitePlus
S1779 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 11964068, 18088087, 24275569, ...15310280
S1788 Phosphorylation PhosphoSitePlus
S1793 Phosphorylation PhosphoSitePlus
S1824 Phosphorylation PhosphoSitePlus
Y1835 Phosphorylation PhosphoSitePlus
S1848 Phosphorylation PhosphoSitePlus
S1852 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation Q13153 (PAK1) HPRD 10092231
S1208 Phosphorylation Q13177 (PAK2) HPRD 10748018
S1438 Phosphorylation HPRD 20166139, 18088087, 20058876
S1760 Phosphorylation Q13177 (PAK2) , Q13555 (CAMK2G) HPRD 10748018, 18088087, 2160950
S1772 Phosphorylation HPRD 18088087
S1773 Phosphorylation HPRD 19651622
T1774 Phosphorylation HPRD 19651622, 18088087
S1776 Phosphorylation HPRD 19651622, 18088087
T1778 Phosphorylation HPRD 18088087
S1779 Phosphorylation HPRD 19413330, 19651622, 18088087
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 18088087
S13 Phosphorylation HPRD 19651622
T14 Phosphorylation HPRD 19651622, 18088087
S16 Phosphorylation HPRD 19651622, 18088087
T18 Phosphorylation HPRD 18088087
S19 Phosphorylation HPRD 19413330, 19651622, 18088087
Site PTM Type PTM Enzyme Score Source PMID
S1369 Phosphorylation HPRD 20166139, 18088087, 20058876
S1691 Phosphorylation HPRD 18088087
S1703 Phosphorylation HPRD 18088087
S1704 Phosphorylation HPRD 19651622
T1705 Phosphorylation HPRD 19651622, 18088087
S1707 Phosphorylation HPRD 19651622, 18088087
T1709 Phosphorylation HPRD 18088087
S1710 Phosphorylation HPRD 19413330, 19651622, 18088087
Site PTM Type PTM Enzyme Score Source PMID
S1438 Phosphorylation HPRD 20166139, 18088087, 20058876
S1709 Phosphorylation HPRD 18088087
S1721 Phosphorylation HPRD 18088087
S1722 Phosphorylation HPRD 19651622
T1723 Phosphorylation HPRD 19651622, 18088087
S1725 Phosphorylation HPRD 19651622, 18088087
T1727 Phosphorylation HPRD 18088087
S1728 Phosphorylation HPRD 19413330, 19651622, 18088087
Site PTM Type PTM Enzyme Score Source PMID
S1369 Phosphorylation HPRD 20166139, 18088087, 20058876
S1640 Phosphorylation HPRD 18088087
S1652 Phosphorylation HPRD 18088087
S1653 Phosphorylation HPRD 19651622
T1654 Phosphorylation HPRD 19651622, 18088087
S1656 Phosphorylation HPRD 19651622, 18088087
T1658 Phosphorylation HPRD 18088087
S1659 Phosphorylation HPRD 19413330, 19651622, 18088087
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 18088087
S13 Phosphorylation HPRD 19651622
T14 Phosphorylation HPRD 19651622, 18088087
S16 Phosphorylation HPRD 19651622, 18088087
T18 Phosphorylation HPRD 18088087
S19 Phosphorylation HPRD 19413330, 19651622, 18088087


Q15746 (MYLK) as PTM Enzyme



Substrate Site Score Source PMID
O14950 (MYL12B) T19 PhosphoSitePlus 11781833, 26334100
O14950 (MYL12B) S20 PhosphoSitePlus 11781833, 12571246, 26334100
P10916 (MYL2) S15 PhosphoSitePlus 22120626
P24844 (MYL9) T19 PhosphoSitePlus   Signor 19851336, 18835557
P24844 (MYL9) S20 PhosphoSitePlus   Signor 19851336, 18835557, 3839510
Q05682 (CALD1) S73 neXtProt 20536391
Q05682 (CALD1) T666 neXtProt 20536391
Q05682 (CALD1) S700 neXtProt 20536391
Q05682 (CALD1) T735 neXtProt 20536391
Q05682 (CALD1) S744 neXtProt   Signor 20536391
Q15746 (MYLK) T1748 neXtProt 7711037
Q15746 (MYLK) S1760 neXtProt 7711037
Q15746 (MYLK) S1768 neXtProt 7711037


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048508 (hMYLK/Phos:1) pS1208,pS1759 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y231 * Biomuta DOID:3571 / liver cancer [ icgc ]
S287 I287 Biomuta DOID:1324 / lung cancer [ cosmic ]
T335 N335 Biomuta DOID:363 / uterine cancer [ tcga ]
Y464 F464 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K608 T608 Biomuta DOID:1909 / melanoma [ cosmic ]
S815 Y815 Biomuta DOID:363 / uterine cancer [ tcga ]
S911 L911 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ]
K1101 M1101 Biomuta DOID:3571 / liver cancer [ tcga ]
T1230 K1230 Biomuta DOID:3571 / liver cancer [ icgc ]
Y1410 C1410 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
S1617 F1617 Biomuta DOID:3070 / malignant glioma [ tcga ]
T1624 S1624 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T1748 A1748 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T1748 M1748 Biomuta DOID:10534 / stomach cancer [ tcga ]
S1759 Y1759 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1760 Y1760 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1760 C1760 Biomuta DOID:9256 / colorectal cancer [ tcga ]