Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15717 / ELAV1_HUMAN
Protein Name ELAV-like protein 1
Gene Name Name: ELAVL1
Synonyms:HUR;
Organism Homo sapiens (Human)

PRO ID PR:Q15717
DAG View
PRO Name ELAV-like protein 1 (human)
Definition An ELAV-like protein 1 that is encoded in the genome of human.
Short Label hELAVL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15717 (ELAVL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 21406692
S2 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y5 Phosphorylation PhosphoSitePlus
R14 Methylation PhosphoSitePlus
Y26 Phosphorylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus   RLIMS-P 21884634
K50 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
Y63 Phosphorylation P52333 (JAK3) PhosphoSitePlus 24106086
Y68 Phosphorylation P52333 (JAK3) PhosphoSitePlus   RLIMS-P 24106086
K72 Ubiquitination PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
S88 Phosphorylation O96017 (CHEK2) PhosphoSitePlus   RLIMS-P 24865968, 17317627, 21745814
K89 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
S100 Phosphorylation O96017 (CHEK2) PhosphoSitePlus   UniProt 17317627, 23186163, 21745814
K104 Ubiquitination PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
T118 Phosphorylation Q16539 (MAPK14) , O96017 (CHEK2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 17317627, 24865968, 19528229, ...21862584, 21745814
K120 Ubiquitination PhosphoSitePlus
T142 Phosphorylation RLIMS-P 32413989
T143 Phosphorylation PhosphoSitePlus   RLIMS-P 32413989
S146 Phosphorylation PhosphoSitePlus
R147 Methylation PhosphoSitePlus
S158 Phosphorylation P17252 (PRKCA) PRO   PhosphoSitePlus   RLIMS-P   UniProt 17392515, 18285462
K171 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32413989, 23186163
Y200 Phosphorylation P52333 (JAK3) PhosphoSitePlus   RLIMS-P 24106086
S202 Phosphorylation P06493 (CDK1) , P24941 (CDK2) , Q00535 (CDK5) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 18234856, 23186163, ...17081983, 18220336, 18847512, 22829587, 27303922, 18593881, 18927508, 18669648, 30154469, 32047552, 24416409, 29563610, 19690332, 20068231
R205 Methylation PhosphoSitePlus
R206 Methylation PhosphoSitePlus
R217 Methylation PhosphoSitePlus   UniProt 24129315, 12237300
R219 Methylation PhosphoSitePlus
S221 Phosphorylation Q05655 (PRKCD) , P17252 (PRKCA) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23978401, 24492650, 30091833, ...18285462, 17392515, 20086103, 24416409, 32047552
S242 Phosphorylation PhosphoSitePlus   RLIMS-P 18948743, 32047552
K283 Ubiquitination PhosphoSitePlus
S304 Phosphorylation O15111 (CHUK) PhosphoSitePlus   RLIMS-P 23115237
K313 Ubiquitination PhosphoSitePlus
S318 Phosphorylation Q05655 (PRKCD) , P17252 (PRKCA) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24492650, 18285462, 23115237, ...20086103, 23921630, 21310943
K320 Acetylation PhosphoSitePlus
K320 Methylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S197 Phosphorylation HPRD 18767875, 17081983, 20068231
Y200 Phosphorylation HPRD 15592455, 19651622, 20068231
S202 Phosphorylation HPRD 17322306, 18767875, 19664995, ...19651622, 18669648, 20068231, 17924679


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047275 (hELAVL1/InitMet-/Phos:2) pS158,pS221 PRO
PR:000047276 (hELAVL1/InitMet-/Phos:3) pS221,pS318 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15717 (ELAVL1) S304 Q9Y297 (BTRC) unknown eFIP 23115237


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 C2 Biomuta DOID:1324 / lung cancer [ tcga ]
Y26 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T32 A32 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y68 C68 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T80 M80 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S100 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T118 N118 Biomuta DOID:3571 / liver cancer [ icgc ]
T143 A143 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R205 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R217 T217 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S221 F221 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]