iPTMnet Report for Q15691 (MAPRE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15691 / MARE1_HUMAN
Protein Name Microtubule-associated protein RP/EB family member 1
Gene Name Name: MAPRE1
Organism Homo sapiens (Human)

PRO ID PR:Q15691
DAG View
PRO Name microtubule-associated protein RP/EB family member 1 (human)
Definition A microtubule-associated protein RP/EB family member 1 that is encoded in the genome of human.
Short Label hMAPRE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15691 (MAPRE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
Y6 Phosphorylation HPRD   PhosphoSitePlus 18491316
S7 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus   RLIMS-P 27721984, 29228685, 28039481
K60 Acetylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
K66 Acetylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
K76 Methylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
Y124 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455
S140 Phosphorylation PhosphoSitePlus   RLIMS-P 22123863
K148 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K151 Methylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
T154 O-Glycosylation GlyGen 16408927, 33214551, 35008409, ...34725712, 30059200, 31373491, 34019948, 31492838, 32119511, 34229054
T154 Phosphorylation PhosphoSitePlus   RLIMS-P 27721984, 29228685
S155 O-Glycosylation GlyGen 16408927, 33214551, 35008409, ...34725712, 30059200, 31373491, 34019948, 31492838, 32119511, 34229054
S155 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 24930764, 17287340
S156 O-Glycosylation GlyGen 16408927, 33214551, 35008409, ...34725712, 30059200, 31373491, 34019948, 31492838, 32119511, 34229054
S156 Phosphorylation PhosphoSitePlus
S157 O-Glycosylation GlyGen 16408927, 33214551, 35008409, ...34725712, 30059200, 31373491, 34019948, 31492838, 32119511, 34229054
S165 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18212344
T166 O-Glycosylation GlyGen 31373491
T166 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 24930764, 17287340
K174 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus   RLIMS-P 27721984, 29228685
K212 Sumoylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
K220 Acetylation PhosphoSitePlus   UniProt 23001180
K220 Ubiquitination PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus   RLIMS-P 27698945
Y268 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13303 (KCNAB2) S9 Q15691 (MAPRE1) unknown eFIP 21357749
Phosphorylation Q13586 (STIM1) S621 Q15691 (MAPRE1) inhibited_association eFIP 24095720


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K66 T66 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K76 T76 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K83 N83 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K89 T89 Biomuta DOID:363 / uterine cancer [ icgc ]
S165 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
K182 N182 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K212 Q212 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K212 N212 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y268 H268 Biomuta DOID:363 / uterine cancer [ icgc ]